In the past I have taken both brand name and generic Wellbutrin XL and noticed a significant difference. I've tried to switch from brand name to generic twice in the last couple of years, and both times came to the realization that the generic Wellbutrin/ Bupropion XL is nothing like brand name. But recently my insurance co-pay has gone from $50 to $150, and I'm wondering if anyone has found a generic Wellbutrin XL that feels equivalent to the brand name. Any opinions on what the best generic is?
What is the best generic Wellbutrin?
Question posted by Effect on 11 Feb 2016
Last updated on 9 October 2023
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
41 Answers Page 3
lch1000
31 Aug 2018
I believe that Mylan Pharmaceuticals Inc.. makes a good generic. However, many chain pharmacies are switching to other generics because the contracts are cheaper.
bluesinthenight
14 Nov 2018
The FDA Drug Shortages website states that Mylan Labs discontinued the manufacture of bupropion in all forms and doses as of June 19, 2018. The reason given was "The discontinuation of this product is a business decision." That's it. I called Mylan and they confirmed it. Some pharmacy's vendors have a back stock of Mylan, so it may be possible to get some. I did. With each disastrous attempt to switch generics, I went back on the Mylan generic until I was ready to try another. I have frantically searched for a replacement. Solco was horrible. Headaches, nausea, brain fog and more. Watson took me up like a rocket for 4 hours and dropped me like a lead balloon at 8 hours (so much for Sustained Release), and after a week I was having suicidal ideation. Sandoz has been the best so far. It is genuinely sustained release, but I think I'm getting more of the active ingredient (FDA says anything between 80-125% of the active ingredient is "equivalent".
I'm still trying to figure out how they can make that claim with a straight face). My only problem with Sandoz has been an increase in the loudness of the ringing in my ears. I'm on a high dose (400 mgs daily) and I'm going to try to gradually reduce that to 300 mg daily and hope that will help my tinnitus.
Wellbutrin_111
20 April 2019
Attention!! Mylan Brand Wellbutrin Has been discontinued. I personally take the 150SR, I’ve tried the brand as well as a couple of other generics and none of them work for me. I am putting together a petition online to send to Mylan. I am also paying for a RADIO COMMERCIAL lthat will be played during the Ben Shapiro show as well as others on a Philadelphia radio station (Fox 1180) urging people to call whatever number I am able to get. I have no animosity towards the company ( no lawsuits etc.). I’m sure it was just a business decision but they need to know that a lot of people are depending on that specific medication. If you read this and are willing to help in one way or another even if it’s just signing the petition please let me know as long as at least one person gets back to me I will supply some form of contact information. Of course I am staying anonymous personally. PLEASE HELP, WE CAN DO THIS!!!
PointReyes
20 July 2018
I just started taken bupropion for the first time ever, and am on the generic from BluePoint Labs. Anyone have experience with them? I'm feeling nothing, barely any side effects (just a little in the stomach once in a while and tight jaw sometimes) and no effect on my depression, unfortunately. Do you think it's worth it to try other generics? I could use the couple for Wellbutrin, but when that runs out then I have to go back to generics so there's no point really.
PointReyes
20 July 2018
I meant: I could use the coupon for Wellbutrin, but when that runs out then I have to go back to generics so there's no point really.
Aluviel
20 July 2018
Id say Use the coupon to help ease your body into taking it.. Then ease onto the myland brand by taking half and half. I hear these drugs can take up to 3 months to work and some claim overnight results. A lot of people go to Canadian pharmacies or Mexico to get the real thing because its too expensive here. Its such a sham that the US charges so much and its citizen DIE because they cant get the meds they need at an affordable price.
A lot of depression r mental health believe it or not can be corrected through diet alone..
When my doctor told me that and to go hit the gym, I just blew it off until I had no other option. I finally relented and cut all wheat sugar and crap like dairy from my diet and for about 3 days the withdrawals from sugar were bad. I guzzled the water.. after that I incorporated basic treadmill and cardio with good music.
You might also try Brain waves from you tube too. I can say I am healthy strong, happy and successful simply by disciplining my diet and light working out. I am so glad I didnt get on any meds. If you would like more helpful tips you can follow Sallykpopx on fb or twitter. Good luck!
missashleynicole
25 Sep 2018
What was your end result with BluePoint labs? Are you still taking it? I got my refill today (Mylan runs out in 4 days :( ) and so I got Sandoz. The BluePoint Labs was $10 than Sandoz.
pamelabills
20 July 2018
According to a knowledgeable professional who has worked in mental health for probably 20 years, PAR genetic brand is best because it is closest to the exact formulation of the brand name wellbutrin.
Aluviel
20 July 2018
Well even if it is the closest. whatever fillers they use in combination with other drugs, may just cause an unwanted reaction. Heck even with basic vitamins you have to be careful what gets along with each other. I have hear nothing but good things about Mylan, All of them gave me bad reactions so I started hitting the gym and socializing more.
Jade57
15 March 2018
I've started Wellbutrin xl 150 mgs for 3 weeks and increased to 300 mgs after then. All together I'm already in week 4 and I see no difference. Nothing! It's like I'm taking a sugar pill! I buy my prescriptions at Costco and the generic they use is made by Par Pharma. Do you think the lack of effect could be because of the generic?Any experience with that one?
Frustrated
Inactive
5 April 2018
The website Dailymed lists all bupropion generics, the various companies, the ingredients, a picture of the bottle label, etc. There are over 12 companies that manufacture bupropion SR, 150 mg. Sandoz makes 3 different generics, all with different ingredients. One is made in China, one in TN, and one in NY. I am trying the Sandoz SR 150 mg manufactured by Epic Pharma for Sandoz. Product of Italy. The NDC # is 0185-0415-01 or 60. The ingredients closely match Glaxo’s Wellbutrin SR. Will post results. If you have had success with a generic, please post the NDC number for reference. Mary from nola
DocD02003
27 June 2018
Hi Jade57,
I've been taking generic Wellbutrin XL 450mg (300mg & 150mg tabs) for 6 yrs. It was added to boost the efficacy of my other antidepressant, Celexa, then Zoloft. Overall, it has been very effective. I've always been given the Mylan generic from Walgreen's, but last week when I picked up my prescription, the manufacturer was Par. Up to that point, it was working like a charm. Once I started taking Par's version last Friday, I've been spiraling. I'm irritable and actually starting to have suicidal ideation. I take other meds, too, but the Wellbutrin was the only thing that changed. Everyone responds differently to medications, so keep that in mind, but it's so frustrating to be doing so well just to have the pharmacy switch things up to save a few bucks & BAM!! Everything goes down the drain. Needless to say, I've stopped taking it and now I'm on a mission to find a pharmacy that uses Mylan. I hope that you feel better soon & I hope this helps.
bluesinthenight
7 Aug 2018
Mylan has stopped making bupropion since June of 2018. I read it online and phoned Mylan to confirm it. It's true. Since I was switched to generic bupropion from Wellbutrin, I have taken Mylan brand 200 SR. It's worked well and I've had no issues. Walgreens switched me to Solco and I've had a terrible time. I feel like I've been shot up with epinephrine constantly, I'm having suicidal thoughts again and my blood pressure is running between 145/95 - 165/105. I found a stash of the Mylan brand and began taking it a few days ago and I'm starting to feel better. I'm depressed, though, that Mylan is no longer making bupropion and I don't know what will happen on the next generic I try - and I can't figure out which one to try. The companies have been bought out by other companies so many times, I won't know what I'm getting.
missashleynicole
20 Sep 2018
I just got off the phone with a Mylan rep and she said the 150mg will be back in stock at the end of October, but the 300mg will not be back until January 2019. This is disheartening as I had started with Mylan and then my pharmacy switched manufacturers (Lupin manufacturer). After 10 days I started relapsing. I had to go back to the pharmacy and request Mylan. After one week back on it I was good again. I have been since then and now I am learning of the shortage. The other manufacturer my pharmacy has in stock is Cipla. I may try it or call around for Sandoz.
bluesinthenight
20 Sep 2018
Just got off the phone with Mylan and they said they will be discontinuing the SR or XL versions of bupropion (in all dosages). She couldn't give me a date. She may be wrong. It's happened before. Talk to 2 different people at the same place and get 2 different answers. I take 400mg of The SR daily (in 2 separate doses). I'm currently trying the Watson brand bupropion 200 SR tablets and the jury is out, but I've felt okay. I haven't had the awful side effects with it that I had with Solco (elevated blood pressure, nausea, headaches, jitteriness, and more), but it seems to have a different release and peak time than Mylan. Watson seems to peak at about 4 hours (for me). I was trying out taking a Watson in the morning around 8 am and a Mylan in the afternoon around 3pm. Between 4 and 6pm I couldn't keep my eyes open. It would seem that the Watson was at it's lowest after 8 hours (4pm) and the Mylan is a much slower release.
I'd finally become alert again between 6 and 7pm but have had trouble sleeping at night. Gosh, I hate taking these drugs! Today I'm trying taking Watson both in the morning and afternoon, hoping I won't have the afternoon somnolence and will be able to sleep at night. This sounds like a whiny baby, but it's so unfair that we have to be guinea pigs for the drug companies because the FDA has such a broad definition of "equivalency."
missashleynicole
22 Sep 2018
You are right about the misinformation. I spoke with Mylan rep a month ago who said it would be back in stock by end of September and this rep I spoke to a few days ago said the previous rep must have been looking at the 100mg and not 300mg. Go figure. Got my refill with Sandoz so I will see if it works the same.
missashleynicole
13 Dec 2018
I wanted to update on starting the Sandoz brand back in early October. I did not notice a difference the first month (October), but this past month and a half (November to mid December) I have had several "cloudy days". I feel like it is just not working well enough. Like it is just barely keeping me out of the pit. I have had several down days recently. I checked on the Mylan status this week and they are still out of stock. Going back to the dr this afternoon to see what my next option is.
Smiling-again
19 Feb 2019
****. Even if you don't use Mylan brand or even if you hate it please read my second paragraph!! ***
GOOD NEWS my fellow Wellbutrin users! I think I may be onto something! I switched to Mylan 100 mg and it's working even better than the Mylan 150 SR! Mylan is NOT discontinuing the production of their 100 mg pill.
Mylan is still manufacturing this and it's NOT on back order and I have had GREAT luck with it. Better than the 150 SR! I take two in the morning and two in the evening (total of 400 mg). This makes me wonder if ALL OF THE GENERICS WOULD WORK like the brand name if you take take them as I do.
Smiling-again
19 Feb 2019
My Walgreens will order Mylan for me. The ordered it and it was in the next day. I'm assuming you have access to a Walgreens???
****. Even if you don't use Mylan brand or even if you hate it please read my second paragraph!! **
GOOD NEWS my fellow Wellbutrin users! I think I may be onto something! I switched to Mylan 100 mg and it's working even better than the Mylan 150 SR! Mylan is NOT discontinuing the production of their 100 mg pill.
Mylan is still manufacturing this and it's NOT on back order and I have had GREAT luck with it. Better than the 150 SR! I take two in the morning and two in the evening (total of 400 mg). This makes me wonder if ALL OF THE GENERICS WOULD WORK like the brand name if you take take them as I do.
flutterbykisses1
15 Feb 2018
I have been taking the generic form of Wellbutrin XL for many years now, only because my insurance won't pay for the brand name and, at $1000 a month, I can't afford it. If I could I would pay to have that instead of any generic medication, in a heartbeat! The generic Bupropion XL 300mg pills I take are small and round and made by Par Pharmaceuticals. My pharmacy started getting the drug, that I've taken for years, from a different manufacturer (Cipla USA Inc.) without notifying me. I only noticed because these new pills were oblong and larger. I did not think anything of the switch because I have always been told that the generic is the same as the name brand, just cheaper.
I took one of the pills from the new manufacturer and within hours I started experiencing extreme anxiety, rapid heartbeat, muscle cramps, elevated blood pressure, headache, shivering, "brain zaps"! It was a horrible experience, and I truly did feel like I was going crazy! I am so digusted with us not being able to have access to the medications we need that I even started a change.org petition to urge the FDA to actually do their job. Anyone interested in signing can look it up. I shared more of my story and others experiences about this issue on there.
The FDA "regulates" by mandating that generic forms of prescription medication contain the same active ingredient as the brand name, but allows the generic product to have as much as 20% less of the active pharmaceutical ingredient. Also the agency allows the generic version to use different inactive ingredients, including binders to hold the pill together and time release agents to disperse it. I feel like a lot of the issue is the dispersing agent because some generics actually feel like they "dump" the drug into my system all at once, or a lot of it anyway.
Inactive
14 March 2018
I have been taking GSK brand Wellbutrin SR, 150 m.g., for many years. Four months ago, I had to switch generic bupropion SR. Based on the comments on this thread, It was between Mylan or Sandoz. I chose Mylan SR, 150 mg, 2/day. I felt a noticeable difference within weeks. I was constantly sleepy, low affect, lack of motivation, and little relief from depression. The price of the brand from my drug plan in 2018 is $600/90 days. There is no longer a patient assistance program from GSK. I felt 100% better on brand Wellbutrin. Before trying a second generic, namely Sandoz, I am asking if there is a way to acquire the brand Wellbutrin SR, 150 mg, without the high cost? Bob, are you still taking Sandoz with success? Is it SR? Can anyone else share their experiences in making the switch? I am on a Medicare Part D drug plan. They have a program called Extra Help whereby any brand drug is $8.75. You have to meet income and asset guidelines. I do not qualify. So I will get a 30-day supply of bupropion SR from Sandoz to try it and compare it with Mylan. Thanks. Mary
sb50
18 May 2018
I haven't paid much attention to what Wellbutrin I was taking until I switched pharmacies from the military source to Veterans Affairs Hospital. Tricare, my post-retirement insurance used Walgreens as a source. When I switched to VA once I was qualified, I was given a lower dose (by mistake) and was peach-colored tablets. I didn't take much notice, again, not paying attention and trusting the doc/pharmacy. I still have both bottles and I take one or the other off and on, but ignorant of the difference until I started getting sleepy which annoyed the hell out of me and I was exhibiting ADHD symptoms- restlessness, confused and often feeling chills in my body- I was worried- because my treatment was for major depressive disorder.
Instead of going to VA doctor because it was going to take too long to get an appointment, I went to my Tricare doctor 30 miles away where I moved from and complained about the Wellbutrin not working and asked to be screened for ADHD- doctor was puzzled. Well, to make a long story longer, I was given Adderall, but only to take it when needed and to not take it with Wellbutrin. Then I thought again about the doctors reaction, remembered the difference in the medication colors and I was also researching (on Reddit) Adderall side effects online and stumbled on the difference of generic vs. brand Adderall. Aha! So I checked both bottles and found that I had a different dosage and different generic sources- Sandoz (from Walgreens) and Mylan (from VA Hospital Pharmacy)... I took the Mylan one more time and it made me sleepy within 10 minutes. I got to the bottom of the issue... now browsing in this site and now validated my suspicions. Thank you so much. I'll also check on Reddit!
flutterbykisses1
20 May 2018
Oh my god. Completely incompetent doctors! I'm so sorry you've went through all of that. I hope you have found the answers you need to find relief.
Jk112
15 Jan 2018
I’ve also had many problems. Finding the one that works best, has been a royal pain!
I recently had a coupon for the Brand name WellbutrinXL 300, that would make the cost $5 or less! I thought, YES! If this generic is working, the brand should work even better, right? Not so much! Well, between my insurance & this coupon, it was FREE for 3 months. The coupon exp 12/31/17 & now I have to go back to the generic. I should also add, my 3 months on the brand were NOT what I’d hoped. My depression dipped, my nerves were fried, I was isolating & most days I couldn’t even stand myself. I Remember thinking “my body is trying to adjust to the brand name.”
Now I’m making the switch back to my trusty generic & I feel like I have the flu! Headaches, body aches, nausea, severe stomach pains... My first thought was I have the flu. Then I realized I don’t have a fever. I started putting 2 & 2 together. I remember this feeling when I switched from the generic to the brand... YUCK!
Never again!
To answer your question...
I found the best generic “FOR ME” is a round, coated tablet with the imprint “A 102” I have gotten friendly with my pharmacist, due to the issues I’ve had over the years, she knows “A102” is the only one I can take. She works hard to make sure I’m taken care of. She tells me there are several different generics on hand in the pharmacy. They typically grab the 1st bottle on the shelf & fill the script.
Find a pharmacist you feel comfortable talking to & explain what’s going on. My reactions to another generic was SEVERE! It’s OVAL & it is NOT coated. I don’t recall the imprint.
I became severely depressed, almost immediately & extremely suicidal in less than a week. This has happened 3 different times, over many years, before I figured it out. There is definitely a difference when it come to generics! This generic A102 is amazing! Idk what I’ll do, if there comes a day & I’m unable to get my hands on it.
Best of luck to you. I hope this is helpful.
WildcatVet
15 Jan 2018
The A102 imprint is the generic from Anchen.
Smiling-again
19 Feb 2019
****. Even if you don't use Mylan brand or even if you hate it please read my second paragraph!! ***
GOOD NEWS my fellow Wellbutrin users! I think I may be onto something! I switched to Mylan 100 mg and it's working even better than the Mylan 150 SR! Mylan is NOT discontinuing the production of their 100 mg pill.
Mylan is still manufacturing this and it's NOT on back order and I have had GREAT luck with it. Better than the 150 SR! I take two in the morning and two in the evening (total of 400 mg). This makes me wonder if ALL OF THE GENERICS WOULD WORK like the brand name if you take take them as I do.
Smiling-again
19 Feb 2019
****. Even if you don't use Mylan brand or even if you hate it please read my second paragraph!! ***
GOOD NEWS my fellow Wellbutrin users! I think I may be onto something! I switched to Mylan 100 mg and it's working even better than the Mylan 150 SR! Mylan is NOT discontinuing the production of their 100 mg pill.
Mylan is still manufacturing this and it's NOT on back order and I have had GREAT luck with it. Better than the 150 SR! I take two in the morning and two in the evening (total of 400 mg). This makes me wonder if ALL OF THE GENERICS WOULD WORK like the brand name if you take take them as I do.
JAnders125
10 Nov 2017
CIPLA has been the best for me, but we switched insurance companies and I can't use Target or CVS which dispenses this brand. So I am on the hunt for another good generic. Activis is a fail, I can tell a huge difference, it is inferior.
Aluviel
19 Sep 2017
I have tried the Sandoz manufacture brand and its awful. The first night I had ringing in the ears and dry mouth. I also started off with a shocking pain in my knee. I cut it in half and was having these phantom itches on my back and then hair loss. Im trying to find a pharmacy that carries the Mylan brand. I also started getting huge pimples.. Now my immune system is being compromised with sore throats and cold sores.
Not good.
Aluviel
19 Sep 2017
Has anyone tried the Cipla mnf. brand? No has mylan around here.
Aluviel
19 Sep 2017
Im also on a really heavy period which is another dang side effect.. Im about to just give it up period.. not worth it.. My last comment is gone so Ill ask again.. no one carried Mylan brand of it.. Supposedly Sandoz ranks really high.. I hate it.. Target carries Cipla.. anyone tried it?
Inactive
19 Sep 2017
Hi Aluviel: My CVS pharmacy cooperates with me and orders Mylan brand for me. Walgreen's has also ordered different generics for me. Both pharmacies carry different brands from time to time, but they work with me to order Mylan for me. I just go in a couple of days before I need my prescription refilled, and talk to the pharmacist. She puts in an order for Mylan and I can usually pick it up the next day. Good luck.
Aluviel
20 Sep 2017
WOW thank you! I read that Actavis is also good. Rite Aide can carry it. I will try talking to Target which has CVS inside again tomorrow.
Aluviel
30 Sep 2017
Luckily Rite Aide was asble to order it from Mylan. My hair is still falling out and Im not feeling any better.
Inactive
30 Sep 2017
Hi Aluviel: I just noticed that you were talking about the generic for Wellbutrin XL.
I never was successful with XL, either brand name or generic. I have tried many of the generics by different companies through the years. I only do well with Bupropion SR, the 150 mg time-released tablet once a day, but it is usually prescribed to be taken at 150mgs twice a day. Mylan Bupropion SR worked the best for me with the most benefit, with the least side effects. But everyone is different. I am sorry you are having so many side effects. Hope you feel better soon.
Aluviel
1 Oct 2017
well if the hair loss doesnt stop and this awful pain in my arm that is preventing me from doing my Lateral lifts at the gym I am just quitting.
Inactive
1 Oct 2017
I don't blame you! Have you called your doctor to discuss your problem?
Maybe he/she can suggest another medication or a dose change or something that will help without the hair loss and pain. Let me know how it goes...
Aluviel
2 Oct 2017
Yes I already did and we changed it to the instant release at a lower dose and I can cut that dose in half to 35 mg's. It seems to take the edge off. If I switch to celexia I think? or another drug, those have been reported by consumer to cause weight gain. We will see if the hair loss slows down. The bruising has stopped. I have some terrible pain in my shoulder and will have to take a couple weeks off lifting weights. Ill keep things posted^^ The nightmares have slowed down too. I had my pharmacy get the Myland brand.
Bob_FL
23 Jan 2017
Hi Effect - there are huge differences in the generics for Wellbutrin. I've been taking this med since 1993 and was on the Glaxo brand for many years and then tried several time release versions of XL. None of them worked for me. Now, I'm taking the Sandoz generic 75mg. (3 times per day). I highly recommend Sandoz, and they also make the time release versions as well. Also, other reviewers have said that Sandoz is just as good as the brand. If you order this generic from your insurance company's mail order pharmacy - your co-pay should be the same as for all generics. Good luck - this is a very common problem for those who have tried cheap versions of Bupropion and who are still seeking an effective replacement for the brand.
Inactive
23 Jan 2017
From my personal experience, there really isn't one that is better than any other for everyone. We are all different, so the various generics react quite differently for each of us, due to our chemical makeup.
For me, the bupropion SR (12hr time release) works most effectively. For others, the bupropion XL(24hr time release) works best. And as Bob has said, he likes the bupropion IR (instant release).
Some people find the best one for them on the first try, others have tried many to find the one most effective. Antidepressants are something that sometimes takes a good amount of time to find a good fit. Try to have patience, and don't give up. The right one for you can be life-changing. G
Bob_FL
25 Jan 2017
From reading literally hundreds of comments about the differences between various Wellbutrin generics, the overwhelming consensus is that Sandoz and Mylan get the best reviews. I've tried (4) different generics and just like many others - I've found that Anchen is the least effective (and cheapest) generic. The Teva generic was pulled off the market after the FDA found that they were not complying with the approved formulation. After being on this med for 23 years, here is my recommendation for best to worst generics:
1) Sandoz
2) Mylan
3) Watson
4) Valient
5) Anchen
If you're looking for a brand that is closet to the original by Glaxo - then, Sandoz is the winner. It's also 3 times as expensive as Anchen and is usually not the generic that most pharmacies use because of the price. However, you can order it from your pharmacy and pay $100 per month (without insurance). You asked a terrific question - and here is a specific answer.
GKNY
12 Feb 2017
Thank you all for your comments. I have never been dispensed Sandoz or Mylan generics. Based on the comments I would love to experiment with both. I suffered through TEVA's Budeprion scandal several years ago. I was rushed to emergency rooms several times for unknown causes, almost lost my job, suffered from heightened anxiety and spent weekends in bed. It was the company's greed driven objective to market a generic that was not the bio-equivalent to the name brand. No one, TEVA or the FDA, apologized to those who suffered. Since then I'm mindful about the proliferation of generic bupropion on the market and the FDA honor system that sometimes fails. Each month I never know if I will be dispensed bupropion by Par Pharmaceuticals, Anchen or Activas (TEVA). Nothing I've taken rises to the quality or effectiveness of Wellbutrin. I continue to experience a marked difference transitioning from Anchen to Par to Activas.
Anchen without question makes me feel fatigued, foggy, disinterested and more agitable. Activas lifts my energy and mental clarity, less paranoia, but motivation remains an issue. I will pursue the Sandoz generic if it's bioequivalency is close to or matches the name brand.
Bob_FL
17 Feb 2017
Let us know which one you like better. Mylan makes the 300xl with a slower time release than Sandoz 150sr which is slow release. Good idea to experiment.
DSWilson713
23 Feb 2017
FYI - If you need a specific generic brand, ask the pharmacy to order it. If they refuse, try a different pharmacy. I discovered the "generic" of Effexor XL that works for me, and my local Walgreens orders it as I had my Doctor write the prescription so that it must be Greenhouse Brand - Generic only.
If you do not ask your Dr. then you are left to rely on the pharmacy techs knowledge which can vary widely.
KASE
27 Dec 2017
I signed up just to respond. Ive tried numerous brands of generics. The benefits ranged from very mild to nothing. I have been on Sandoz generic 100 and it works. Ive wasted years on the other brands.
Inactive
28 Dec 2017
KA KASE 7 hours ago
I signed up just to respond. Ive tried numerous brands of generics. The benefits ranged from very mild to nothing. I have been on Sandoz generic 100 and it works. Ive wasted years on the other brands.
Hi KASE:
Thanks for your response. Are you saying that you have found the most benefit, with the least side effects, with generic bupropion made by Sandoz pharmaceuticals? That's great. You mentioned that you are taking the 100mgs. dose. Have you ever experienced weight gain or other adverse effects while taking it? Have you ever taken the 150mgs dose made by Sandoz? I have taken so many of the generics, I hope that Sandoz can be my go-to one next time I need to take bupropion again. Are you taking bupropion SR or are you taking bupropion XL? I did better on bupropion SR 150mgs, only one time a day instead of twice a day. That worked best for me. How about you? Once or twice a day?
Bob_FL
12 Jan 2018
It's a year later and I'm amending my comment. Wellbutrin 300XL bought from a Canadian Pharmacy which comes in a Valeant bottle is very good. At least it has an outer coating that slows down the extended release. I've also heard that Mylan's version is better than most. Sandoz does not have an extended release and is good for those who never used the XL. You'll pay more for the Canadian 300XL, but it's worth it.
Bob_FL
12 Jan 2018
See my revised comment about Canadian Valeant 300XL and Mylan which are both excellent for ER. Sandoz is good for those who don't want ER.
Bob_FL
12 Jan 2018
Please see revised answer - Canadian Valeant 300XL and Mylan are excellent generics. Sandoz does not have an ER.
azaleahah
28 Feb 2018
Does anyone have any experience with the 150xl version distributed by GLOBAL (oval, yellow, imprint 681)?? I am taking this now & haven't found much mention of it so just very curious.
Thanks
Inactive
20 March 2018
Bob, I am struggling with Mylan generic Wellbutrin Sr. I read your comment about Canadian Valeant XL. Do you mind sharing how do I go about ordering it online? With or without a script? What can I expect to pay for a 90-day prescription. How long have you been on it? Thanks,
Mary
Ocelotee
11 May 2018
I want to take Sandoz's version because it gets the best reviews as far as approximating Wellbutrin.
I called Sandoz's NJ HQ and they say they only make 100mg and claim they never made 75mg tablets of bupropion.
Given that 450mg( 75 mg times 6(150mg 3 times a day)) of Wellbutrin always worked for me in the past, I'm not sure how I would divide 100mg Sandoz tablets into 150 mg, 3 times a day, without breaking the tablet and destroying the very tablet coating that may be what makes Sandoz effective for the majority of generic bupropion users in the first place.
bluesinthenight
26 Oct 2018
I've been taking Mylan bupropion for many years, but found out that they discontinued making it as of June 2018 (confirmed with Mylan and FDA). In a panic, I've been trying different generics. The first I was given was Solco. I was nauseated, had headaches, couldn't think clearly, was irritable and generally miserable. Then I tried Watson. It took me up quickly, peaked at 4 hours and dropped me down hard at 8 hours. So hard that I could barely stay awake. I would also get uncomfortable adrenaline rushes. I tried taking it at different times to avoid the peaks and valleys, but discontinued taking it when I became severely depressed after being on it only a week. Then I tried Sandoz. Eureka! It is genuinely sustained release - with no peaks and valleys. I feel good. No nausea, no headaches, no depression or adrenaline rushes provoking anxiety. The only problem I've had is that it seems to louden my tinnitus somewhat.
I think that may be because I might be getting more of the "active ingredient" than I was with Mylan.
Here's a synopsis from best to worst:
1. Sandoz
2. Mylan (discontinued manufacturing but still available from some pharmacies)
3. Watson (didn't like it at all)
4. Solco (the absolute worst)
Good luck everyone!
Zinniaz
7 Nov 2018
bluesinthenight:
I have also had a horrid experience with Solco. I had been taking Sandoz , then out of nowhere I was given Solco.
They're both pink, I didn't even really notice the change . All I knew was something was NOT right . I matched the timing to when i got my refill of bupropion. It was like day and night.
It was like I wasn't taking it at all! I was SOOOOOO TIRED and brain fog .
I had found one of my leftover Sandoz pill, so I took it when it was time for my dose.
I was literally wide awake all night (I know that's not good health wise, but it proves to me without a single ounce of doubt that the Solco was literally NOT bio equivalent. Impossible.
I did some more research on this Solco distributor . The actual manufacturer is based in china , and has had TWO FDA WARNING LETTERS SENT TO THEIR FACILITY!!! They were found to be tampering with their records and i so wish I could find this letter .
I am going to search for the letter when I'm able to use my tablet ASAP. The manufacturer in china is named with two names like "Zhang Z??? "
And Solco distributes it
Today I have realized the generic bupropion I've been taking is not the same manufacturer from last refill- but I didn't notice the difference. My new realization wasn't biased at all.
I have been SO tired lately. My self esteem has oddly been very very low, in a way that I've been worried it was just not working anymore.
I've registered on here after seeing the most recent post was 11 days ago.
I will update my details asap .
Bob_FL
28 Dec 2020
Okay - it's 4 years later since my last post. I was fortunate to have insurance and was accepted into the Wellbutrin "piggy back card" program. You can only get in if you have insurance like United Health. However, I was paying $5 total on this program. Now, I've turned 65 and will be on Medicare, so they won't allow me into the program. This presents a problem since brand Wellbutrin XL is $2,200 for 30 tabs. If you're under 65 try the authentic Wellbutrin discount program - it was fantastic. But, make sure it's the right webpage that offers the real program. There's an 800 number to call and you download your card that they will activate for you. Now, because I'm no longer eligible, I'm buying from Cloud Pharmacy in Canada. They're ligit. So, I just bought the Canadian Valeant Brand (not the original US brand), and we'll see what happens. I think it costs around $150 for 90 pills.
I'm not expecting anything like the US Smith-Glaxo brand, but I hope it's better than the US generics which get terrible reviews - all of them. It's unbelievable that they can't make a reasonably priced version of a med that hones in on dopamine, and there's nothing else that I've heard of that's coming out soon. To make matters worse, many of the generics are made in China, India and Turkey where regulations are probably nil. So, I'll try the Brand Canadian formula and see what happens. It's a disgrace that so many people notice the feeble effects of Wellbutrin generics as opposed to the US $2,200 rip-off original.
D_on_WXL
2 July 2021
Bob
You are the best!!
I was so upset when I went on Medicare due to LTD to find out that there was no way to get brand Wellbutrin unless I was going to pay 2000 a month-which I can’t. And you cannot use the manufacturer coupon either, as you know. What a disgrace! So I started reading all the comments here and you are the smartest!! Your comments really helped me. I briefly tried Sandoz - so hard to find- but no luck just like all the other bad generics. And yes I read the comments about the patent on the time release. Whole thing is sickening.
Anyway the good news. I have ordered from Cloud and am so grateful to you for all the help you have given me and are giving others. BTW I noticed the pill has WXL instead of the full name (not sure why) but it looks to be all good. I will start on it soon. Just wanted to thank you for being so wonderful!!
All the best,
D
Inactive
12 Feb 2016
Hi Effect. I have taken brand name wellbutrin and generic bupropion through the years.I have taken SR and XL versions of both as well. I had many more side effects with the XL version of both the generic and brand. But the SR version of bupropion seemed to me to be comparable to the brand name one. A few years ago I took Wellbutrin and also Bupropion. The different pharmaceutical companies who produced them made a difference as well. After much time and trying many different generic forms, I found one that worked the best for me, and most like the brand name. It is made by a company called Mylan pharmaceuticals, and it is Bupropion SR 150 mgs, to be taken once or twice a day, depending on the dose your doctor thinks is a better fit for you. I had some very adverse side effects on the ones made by Sandoz pharmaceuticals and Par pharmaceuticals, Globe pharmaceuticals, and Activis pharmaceuticals. I had everything from stomach cramps, to headaches and weight gain, and increased appetite on the other generics. Hope this helps.
fisemicr
16 Dec 2021
This information is a big help. My co-pay is $150 for Wellbutrin but would be like one-tenth that for Bupropion. But I need information on which generic is equivalent as I'm sensitive to different filliers...
WildcatVet
11 Feb 2016
Hi, Effect! The FDA dictates that the quality and quantity of active drug must be precisely identical to the brand name. The problem arises in the *fillers* that used to formulate the tablet/capsules and those include aspartame, saccharin, lecithin, methylcellulose, sorbitan, and various dyes, colorings, and flavorings.
Since there are over a dozen manufacturers of generic bupropion you may find that what works for one person may not work for you. Find one that you tolerate well and request that your pharmacist stock that particular product for you. He can also check manufacturer's products for one that has the same formulation as GlaxoSmithKline's.
Good luck and best wishes, WCV
Smiling-again
17 Feb 2019
@WildcatVet. I am responding to the part of your comment that reads: "Since there are over a dozen manufacturers of generic bupropion you may find that what works for one person may not work for you. Find one that you tolerate well and request that your pharmacist stock that particular product for you. "
***. You don't understand. When you have depression you don't have time to shop around and try each drug individually to see if it works. You'll lose months and months of your life doing this.
Smiling-again
17 Feb 2019
@WildcatVet. I am responding to the part of your comment that reads: "Since there are over a dozen manufacturers of generic bupropion you may find that what works for one person may not work for you. Find one that you tolerate well and request that your pharmacist stock that particular product for you. "
***. You don't understand. When you have depression you don't have time to shop around and try each drug individually to see if it works. You'll lose months and months of your life doing this.
WildcatVet
17 Feb 2019
It requires time and patience. I've been treated most of life with various medications and have only recently found the right combination. Sure, it takes time for these medications to become therapeutic... but what is your option? Live the way you are and let IT control your life?
Smiling-again
19 Feb 2019
You're right. I'm sorry. I'm so mad at pharmacies switching generics on me, and my doctor not believing me about generics not being different from each other and losing months because I can't get out of bed that I just feel so helpless sometimes. :(.
I'm sorry. Please read the comment I wrote today. It has some good information in it.
Smiling-again
19 Feb 2019
Wildcatvet. I'm posting my latest comment here because I realized it was very difficult to find on the website.
****. Even if you don't use Mylan brand or even if you hate it please read my second paragraph!! ***
GOOD NEWS my fellow Wellbutrin users! I think I may be onto something! I switched to Mylan 100 mg and it's working even better than the Mylan 150 SR! Mylan is NOT discontinuing the production of their 100 mg pill.
Mylan is still manufacturing this and it's NOT on back order and I have had GREAT luck with it. Better than the 150 SR! I take two in the morning and two in the evening (total of 400 mg). This makes me wonder if ALL OF THE GENERICS WOULD WORK like the brand name if you take take the 100 mg immediate release.
d1anna
1 Aug 2019
I totally understand! It's a joke to ask your psychiatrist to investigate too. Also when checked most generics have always been found to have too much or too little of the so called "active ingredients". You cannot depend on the FDA,what they say and what they do rarely jive.
WildcatVet
1 Aug 2019
"A generic drug is a medication created to be the same as an existing approved brand-name drug in dosage form, safety, strength, route of administration, quality, and performance characteristics.
A generic medicine works in the same way and provides the same clinical benefit as its brand-name version. This standard applies to all FDA-approved generic medicines. A generic medicine is the same as a brand-name medicine in dosage, safety, effectiveness, strength, stability, and quality, as well as in the way it is taken and should be used.
The FDA Generic Drugs Program conducts a rigorous review to make sure generic medicines meet these requirements. In addition, FDA conducts 3,500 inspections of manufacturing plants a year, ensuring compliance with the agency's regulations on good manufacturing practices.
FDA requires drug companies to demonstrate that the generic medicine can be effectively substituted and provide the same clinical benefit as the brand-name medicine that it copies. The abbreviated new drug application (ANDA) submitted by drug companies must show the generic medicine is the same as the brand-name version in the following ways:
The active ingredient in the generic medicine is the same as in the brand-name drug/innovator drug.
The generic medicine has the same strength, use indications, form (such as a tablet or an injectable), and route of administration (such as oral or topical).
The inactive ingredients of the generic medicine are acceptable.
The generic medicine is manufactured under the same strict standards as the brand-name medicine.
The container in which the medicine will be shipped and sold is appropriate, and the label is the same as the brand-name medicine's label."
d1anna
21 Aug 2019
Do you really think these drug companies comply with the FDA? The FDA does not monitor these drugs unless there is a very good reason, money again is the issue. I agree that fillers cause many problems too.
d1anna
21 Aug 2019
Absolutely!!! Plus the waste of your money
WildcatVet
21 Aug 2019
The FDA monitors ALL medications and manufacturers thereof not only rigorously, but expertly.
Manufacturers must comply with their strict regulations or the drug is pulled off the market until the infraction(s) is/are corrected.
Do I believe that? I sure do.
WildcatVet
19 July 2020
Dear, I've been treated for TRD (treatment resistant depression) since I was fifteen years old. I think I know all about wanting a miracle to happen and have the right drug fall into my hands. Well, guess what... given a little patience, a positive attitude and a willingness to put in some effort, it will.
NaveedZ
26 July 2021
FDA Admits that Generic Wellbutrin is Less Effective than Brand Name. The U.S. Food and Drug Administration (FDA) finally has admitted that the generic of the popular antidepressant Wellbutrin XL is not as effective as GlaxoSmithKline's original drug
WildcatVet
26 July 2021
Your source?
Cine T
26 April 2023
The definition for generics is far from precise.
For one thing, the original manufacturer only patents and makes public the minimum information that prevents competitors from being able to legally sell copies of their product.
But it takes a lot more work to make an effective medicine and they keep that secret.
Experienced manufacturers of generics don't just copy the patent formula but test both the blood bioavailability and medical effectiveness and adjust the process until it actually works.
Cheap generic manufacturers will just copy the original patent formula and get it to pass the test.
The test itself is pretty loose. The pills can have a significant difference of active ingredient from pill to pill. And also can have a significant difference from the patented medication concentration.
The basic process is that they prepare a solution which contains all the ingredients for the formula, then throw in some seed molecules for the desired formula. The seeds cause the ingredients to form similar crystal structures (molecules). Then they dry it and cause the whole thing to crystallize.
Now you have a batch of many different types of crystals. The formula that you seeded, plus many random crystals which were not reached by the seeds and got crystallized in random ways. You have to filter these out because you have no idea what they would do in the body. But this doesn't help you pass the FDA test, and it's not cheap to do, so you just filter out things that might kill somebody and get you sued.
Also, the original patent wouldn't tell you, but some of those might be essential helpers for increasing effectiveness, and the original manufacturer knew to leave them in.
But let's say you're not the cheapest mfg and you do a good job taking out the random stuff. Now you have a batch of crystals of the correct formula. But the reason they call them crystals instead of just molecules is because they are three dimensional structures. Many of these crystals with the correct formulas will be in different 3D configurations (polymorphs). But only some of them are therapeutic, and you have to make sure that you have enough of those polymorphs, and whether you do or you don't varies from batch to batch.
So now you have to filter again. However, technically, your entire batch satisfies the FDA's requirement. You don't have to do this at all. Even if you wanted to, the original patent doesn't tell you which polymorphs in detail. Why would they, they want the patent to cover all polymorphs.
But let's say you're Mylan, and you actually test it on humans and select the combination of polymorphs that have good therapeutic value, and then make sure that you have enough concentration of those, and maybe even filter out the non-therapeutic polymorphs in case they might cause side effects for anybody.
If you're a cheap manufacturer, you just make sure there are no polymorphs that might be dangerous and get you sued. You probably have a good high concentration because you didn't have to throw away half the polymorphs (the mirror image ones often have no therapeutic effect), so you go to test it.
You only have to test how much of it ends up from the pill into the blood stream. And the statistical test is not that restrictive. Even though it's a brain medication, you don't have to test how much gets across the blood brain barrier, and you don't have to show any therapeutic effect whatsoever.
You also don't have to make the half life and dissipation curve be the same as the original drug.
If let's say the original drug has enough purity (of polymorphs) and the right additives to have a high peak in the blood stream, but the generic never reaches a high peak, then both can have the same half life, but the generic never activates.
The peak seems particularly important for bupropion. I missed a few days once when I forgot to bring meds on a camping trip and after I restarted taking it, three days later it still wasn't working. The doctor told me to take an extra 75mg the next day. That kicked it back in (BTW, this is not medical advice for anyone).
It's convenient for the government and pharmacies tp pretend there is such a thing as "same formula" and let the doctors sort it out with their patients, but for some of the more complex drugs like bupropion (which they say, nobody knows why it works) they can't just throw some crystal seeds in a vat and stamp it into a pill like the cheapest manufacturers do.
Even for the generics they shouldn't be just chemical manufacturers making a formula, but should be medical manufacturers making a medication.
Unfortunately, this all causes a lot of inconvenience for the pharmacies and they prefer to convince us that generics are equivalents and pretend that, even though they've just switched from a $80 per bottle manufacturer to a $6 per bottle manufacturer, it's all the same and we have no recourse.
Related topics
wellbutrin, wellbutrin xl, depression, bupropion
Further information
Similar questions
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.