Has anyone taken cymbalta vs Effexor xr?

Yes. Cymbalta's increase in norepinephrine is much stronger and not dose-dependent like Effexor [XR]. The net effect of Cymbalta is that it tends to be more on the activating and stimulating side. Effexor [XR] increases serotonin more than anything else esp. at doses 75 mg/day or less, however it increases norepinephrine at doses: 150-225 mg, and then dopamine at 300 or more mg... So low doses of Effexor [XR] can feel more sedating, almost like Paxil... it's when you get to the high doses of Effexor [XR] that it acts much more like Cymbalta... Higher doses of Effexor [XR] is not getting more of the same, it's like adding a new drug, such as Paxil with Wellbturin or Strattera added to it, that's the interesting part... in contrast taking more and more of a drug such as Xanax will get you more of the same effect and stronger, but that's not the case with Effexor [XR].

Hi, nothing had worked for me. I was at my lowest point in life. Cymbalta has helped me tremendously with no side effects. I have tried Wellbutrin, Zybriid, Lexapro & Prozac. I have not had any issues except 2 brain zaps. Good luck

Hi, hope! I took Cymbalta several years ago but switched to Effexor which was far and above more effective for me.
Good luck!

Do not take cymbalta!!! It is horrible and withdrawal is making me crazy! Headaches, chills, sweats, stomach pain, I will probably lose my husband because of this drug!!! I HATE IT!!!