Trintellix User Reviews & Ratings (Page 3)

• MicMac
• Taken for 1 to 6 months
• October 11, 2018

For Major Depressive Disorder "I've been on Trintellix for about 7 weeks now. I've gone from 5mg to 15mg and about to start 20mg. I've been on many antidepressant meds for over 25 years and nothing has helped like this medication has. I do get the extreme nausea (that's why I didn't give this med a 10 instead of a 9 rating), so I take this at night and sleep through the nausea side effect and no nausea during the day. It has helped me deal with my PTSD, MDD, and anxiety. Now my house is clean, laundry is done, I take time for myself, react in a positive way instead of an emotional negative and defensive way. I have found with therapy and this med my world is changing and I no longer feel broken. My opinion is that it is definitely worth a try if nothing else has worked. This may just be the medication to put you back together again. The benefit of this med outweighs the side effects for me."

• Kat
• Taken for 1 to 6 months
• October 19, 2019

For Depression "I have never felt better than I have since I started Trintellix (on it for depression). Took it for a couple of weeks before side effects went away. My family and friends have noticed how happy I seem, and I will stay on this drug forever. I am 75 years old and have tried many antidepressants, and none have worked as well as this one. No bothersome side effects for me. Hope others have similar luck."

• Rugg
• Taken for 1 to 6 months
• October 21, 2019

For Depression "I was prescribed Trintellix for anxiety disorder and depression. First two weeks I was on 5mg/day, and to be honest, I started to feel a lot worse - constant worry, could not sleep, awful nausea in the mornings. I was considering to stop taking it, and I was so negative about the whole thing. I got back to my doctor who told me, 'You will continue to take it, I want you to be patient.' Doctor prescribed me 10mg/day, and after another week, I saw the first signs of improvement. It took me almost a month to see the first signs of improvement. The first thing which this medicine solved was depression; it has just gone away. I’m currently working on my anxiety symptoms. I’ve been taking it for about 7 weeks now. The most important thing to remember here is: be strong, take the pill, and be patient. It works, and it needs time. Doctor told me she had patients who showed first signs of improvement after 2 months."

• Honey
• Taken for 2 to 5 years
• August 17, 2019

For Major Depressive Disorder "I was diagnosed with Major Depressive Disorder and general anxiety after the birth of my first child who had a major birth defect causing 20 years of significant surgeries. I was put on Zoloft which worked beautifully for over 22 years. It then began to wear off, and I, too, was put on every antidepressant medication ever invented. Nothing ever worked. I continued to try everything, but eventually had a depression breakdown and lost my job of 35 years. Tried ECT, TMS but could not sustain the benefits as I had no medication working following the procedures. Finally was put on Trintellix (20 mg) with Bupropion, and it is still working after 2 years. I pray this will continue to be effective as I will have no other hope if it does not. I experienced no adverse side effects. Not every med works for everyone, as I am sure you have found out. Never give up hope!"

• DCano
• Taken for less than 1 month
• November 17, 2018

For Depression "Day one. Although the comments are mixed, the positive comments give me hope. Hope that I can be happier and more pleasant to be around. I know it's a roll of the dice, but I've got to try something. Starting with 5mg for 7 days and then bump up to 10mg. Hoping for some benefit before Christmas. We're not alone... hang in there, y'all."

• Yay
• Taken for 6 months to 1 year
• September 26, 2023

For Major Depressive Disorder "I tried different medications for around a year and a half, including most of the SSRI family, and some anticonvulsants and antipsychotics off-label. I have GAD and MDD. Trintellix was the only thing to finally work for me. It was a life saver. No side effects to speak of. I take 20mg. Manufacturer's coupon brings it down to only about $35 a month. So grateful I found this."

• cali
• February 23, 2020

For Depression "Trintellex started working by the end of the second week and continues to. I am happier than I have ever been and so impressed that Trintellex was able to get me through the incredibly difficult last two months, e.g changed jobs, had a project with an impossible deadline, the holidays, etc. I'm on 10mg daily. Side effect-wise I have some sexual dysfunction (loss of libido, difficult to achieve orgasm) but right now it seems worth it to feel this good. I've also lost weight. A new wrinkle as of 2 weeks ago is a tinnitus. I only notice it when its totally quiet which hasn't made sleeping the best so I take Trazadone to help with that which works great. After two months, I'm still feeling great on the Trintellex but the side effects aren't dissipating and I'm wondering how long I will be able to deal with them. Definitely not forever. Will update if things change."

• Cward
• April 16, 2016

For Depression "Took 10mg samples in the AM, nausea and dizziness big problem 3rd and 4th day. Stopped for 2 days. Then took 1/2 pill in the evening around 8PM. A little nausea, sleep was affected but adjusting. But I believe it is what I need. I left the house 3 times on the weekend, answered my phone, went into 6 stores and most important, while home didn't lay in bed."

• Works...
• Taken for less than 1 month
• March 12, 2024

For Major Depressive Disorder "I have been on 5 mg Trintellix for 1 month. The only side effects I've had are somewhat dry mouth sometimes, and not being able to sleep as well as I used to. Other than those 2 things, it has worked great for me! For the first 1-2 weeks, I did continue to have some bad days, but starting about week 3, the bad times became less extreme and have continued to do so. My insurance wouldn't pay for it, so I applied for assistance on the manufacturer's website, and received it for free."

• AceDoss
• Taken for 1 to 6 months
• August 7, 2014

For Depression "I have been on every antidepressant under the sun. I kind of started to lose really all hope in everything. SSRI or SNRI's had really negative side effects (mostly sexual) or some would give me 'brain zaps' or other issues. Wellbutrin didn't really do much for me but forced up my dosage of Klonopin I had to take. All around, I would say this one is the best one I have tried so far. I have a very noticeable decrease in anxiety. I have only been on it for a month; the depression is better but still there, and I have random episodes of crying which I never had before (embarrassing as a 26-year-old man). No sexual side effects, no known side effects so far except the crying randomly. Will update later."

• TCano
• Taken for 1 to 6 months
• November 14, 2018

For Depression "This medication changed my whole life. It's expensive, but I've tried a grand total of 6 other antidepressants before this one came along, so I think it's worth every penny. The manufacturer offers additional coverage as well, which knocks down my price $100. I will say that the first 3 weeks of this medication were absolutely the worst. I stuck through it, although I was tempted to stop it, and I'm glad I did. I recommend when you first start Trintellix to take it literally right before you go to sleep so you can sleep through most of the side effects. I initially took it in the mornings, and I would spend the next 2-3 hours vomiting on and off. It wasn't fun! But now I'm feeling very rewarded. It is so strange to not be sad all the time! I feel like I'm living for the first time in my life."

• KyeG
• June 2, 2016

For Depression "I have been on a lot of different medications for depression. Some were awful and terrible, while others were okay or tolerable, and there was even one where I thought that was as good as it's going to get. I was on that a long time. Then, my doctor suggested this. Wow! I can think clearly!! It's definitely a great medication. I have yet to see side effects and I've been taking it for about 6 months."

• Monis
• April 19, 2016

For Depression "Suffer from anxiety and depression, which I had no idea why everything in life irritated me. Started off with 5mg and noticed in the morning that I was completely calm and not yelling at my kids. I no longer have road rage, so that is a good thing for all stupid drivers :)"

• Tim
• March 24, 2023

For Major Depressive Disorder "I’ve only been taking Trintellix for about 5 weeks and I can honestly say that this is the best emotionally that I have felt in years. I’d been taking Pristiq for almost 3 years and it simply was not working. Within a week of starting on Trintellix my mood, attitude, motivation overall well-being have improved 500%. I’m not having problems getting out of bed because I no longer dread the day ahead. My mass anxiety is just gone. I have energy and motivation and I’m once again taking initiative and taking ownership of my life and career. I’ve started doing light workouts again and eating right. This is exactly what I needed because I wasn’t on a good path. Now I’m totally looking forward to life as a grandpa (I’m 54), doing things that I’ve been avoiding and enjoying the ‘empty nest’ life with my wife!"

• Flygi...
• Taken for less than 1 month
• August 26, 2016

For Depression "I am taking 70 mg of Vyvanse and also taking Contrave (which contains Wellbutrin). I was feeling okay, but multiple tragedies kept me in a severe state of depression, anxiety, and overwhelming sense of apathy. Every day I wanted to die. The doctor gave me some samples of this med to take with current meds, and last night was the first time I took it. I did feel nauseous, but my doc had told me to take it at night and with food, so that helped since I went to bed once I started feeling sick. I woke up with so much energy. I actually sprung out of bed ready to take on the day and looked forward to it. I was shocked that it had such a fast effect but so happy because it's been a really long time since I've felt this good. Hoping it will last."

• Elise...
• Taken for 6 months to 1 year
• March 29, 2017

For Depression "This drug has been the best antidepressant/anti-anxiety medication I have ever been on. I have been off and on different medications for the past 10 years. (Prozac, Wellbutrin, Cipralex) The first 2 weeks on this medication were rough with nausea and vomiting. My doctor encouraged me to push through the first two weeks, which I did. After 2 weeks, the nausea went away and I haven't had any side effects since. It's the first medication I have felt a notable difference with. My anxiety is very low. No more tightening chest, vomiting, diarrhea, not being able to breathe when in a situation that would previously make me anxious. Only butterflies in my stomach now. I have never felt better in my life. Very optimistic. Is this what normal feels like."

• Trudy
• Taken for 1 to 6 months
• February 24, 2019

For Major Depressive Disorder "I have taken almost all of the antidepressants with varying results but mainly side effects I couldn't tolerate for the past 25 years. I began taking Trintellix 3 months ago. Starting with 5 mg. It took away my appetite and I lost 10 lbs. Now, I am up to 20 mg. a day and am feeling better. My mood is up and I have more energy. The only side effect is a slight problem falling asleep and my appetite has returned. However, the good outweighs the bad and I am hopeful for the first time in many years."

• Tyler
• August 25, 2016

For Depression "Felt positive effects immediately at 10 mg. Had one day of diarrhea and some nausea, but that went away when I started taking it after dinner. I'm going to ask to be bumped up to 20 mg on my next appointment. Very happy with Trintellix. Works better than Wellbutrin, Pristiq, or Lexapro, and side effects are much less."

• austr...
• Taken for less than 1 month
• June 7, 2015

For Depression "Week 3 on Trintellix. I feel so much better than I have felt in years. I'm 31, and have been on 10 or so different antidepressants in the past. Zero side effects. Other antis seemed to cause huge anxiety. Now with Trintellix, I can stop taking anti-anxiety meds. It's almost as if my brain were a house and Trintellix has opened a door to another room I never knew existed."

• CD9
• Taken for less than 1 month
• December 26, 2019

For Major Depressive Disorder "Huge difference with taking Trintellix in just a couple weeks. I have never responded well to antidepressants. It must get to the right receptors. First time I felt positive and hopeful for the future in over 10 years."

• Anonymous
• August 15, 2014

For Depression "This medication is good. I feel so good that I do not feel the need to eat emotionally. I care about myself again and I feel no need to eat poorly. The only problem I am having is the side effects of being super itchy, and I do get constipated."

• FigsM...
• Taken for 1 to 6 months
• February 23, 2019

For Major Depressive Disorder "I am updating my review of Trintellix. I have now been using it at 10 mg at night for 5 weeks. Feeling better every day. One thing I had a problem with is getting really sleepy early evening (around 5 pm) so I started taking my dose at lunchtime instead of first thing in the morning. That is working wonderfully for me. It has regulated my sleep patterns! Also, a major plus is that it has helped me with my severe social anxiety. I am so happy that I was able to walk into a fast-food restaurant, order, sit, and eat by myself! And enjoy it! I am 56 and never have done that before. I so hope this medication helps you, friends, and if not, I hope you find your happy place wherever it may be. Oh, one more thing... the cost. I have Cigna insurance, and of course, they denied paying for this as it is a level 3 med. My doctor was able to get me approved since I have failed on other ADs, and the copay was $60.00."

• CLH
• Taken for less than 1 month
• October 6, 2019

For Depression "I've battled anxiety and depression since I was a teenager. I was 21 when I first started taking an antidepressant. I'm 34 now and have taken about 3 different antidepressants. Zoloft, paxil, and effexor xr. Effexor worked for several years but I had some side effects such as constantly feeling groggy and tired. It helped the anxiety, but not the depression. I asked about trintellix and was then prescribed it. I could tell a major difference with just 3 days of taking the medication!! So far no side affects, I sleep way less (could sleep a total of 12-15 hours), feel much more happier, more willing to do basic chores, errands, WORK, and the anxiety is suppressed. I just want to say that so far this medication has been life changing for me. Antidepressants are always based on personally trialling them..you have to basically try several to see which one works for you. I love this medicine!"

• Guenda
• Taken for 1 to 6 months
• June 11, 2014

For Depression "A total turn around! I feel like a new person. It's been a long road. I lost my husband of 36 years, 3 1/2 years ago. I had just been surviving; not living. My doctor gave me samples and explained how this medicine works."

• asadl...
• May 27, 2020

For Depression "I'm in my early 30's- been dealing with depression for almost 15 years. My former doc prescribed me trintillex. he swore it was a super "clean" med with out side effects. it's been 2+ years taking it (max 20mg) & I had no positive effects. Don't let your doc tell you it won't/rarely causes weight gain. IT DOES, especially if you're a female. It will continue the longer on it/dose increased. Also, awful GI problems- bad nausea or bad constipation. Also only makes anxiety worse especially if you take in the AM- take in PM you can't sleep ^_^ I would stay away from this drug DEFINITELY if you have anxiety, sensitive stomach, prone to weight gain from meds. I'm done off this in 4 days! can't wait"