Codeine Interactions
There are 508 drugs known to interact with codeine, along with 16 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 124 are major, 381 are moderate, and 3 are minor.
- View all 508 medications that may interact with codeine
- View codeine alcohol/food interactions (1)
- View codeine disease interactions (16)
Most frequently checked interactions
View interaction reports for codeine and the medicines listed below.
- Alcohol (contained in alcoholic beverages) (ethanol)
- Aspirin Low Strength (aspirin)
- Ativan (lorazepam)
- Augmentin (amoxicillin / clavulanate)
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Lexapro (escitalopram)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Nexium (esomeprazole)
- OxyContin (oxycodone)
- Paracetamol (acetaminophen)
- Phenergan (promethazine)
- Prozac (fluoxetine)
- Ritalin (methylphenidate)
- Seroquel (quetiapine)
- Symbicort (budesonide / formoterol)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Valium (diazepam)
- Ventolin (albuterol)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Xanax (alprazolam)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Codeine alcohol/food interactions
There is 1 alcohol/food interaction with codeine.
Codeine disease interactions
There are 16 disease interactions with codeine which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
More about codeine
- codeine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (68)
- Drug images
- Latest FDA alerts (6)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: antitussives
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.