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Promethazine User Reviews & Ratings (Page 5)

Brand names: Promethegan, Antinaus 50, Anergan 50, Adgan Phenadoz

Promethazine has an average rating of 7.2 out of 10 from a total of 373 reviews on Drugs.com. 65% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Promethazine

  • HDano
  • Taken for less than 1 month
  • August 1, 2020

For Sedation "My physician of three years thought it wise to change from Ambien 10 mg to Phenergan 25 mg for no apparent reason other than he feared Ambien dependency. Well yes I have primary insomnia per a sleep study, prescribed Ambien 10 mg and it has worked well for 19 years. Never needed to increase the dose. The Phenergan/ promethazine 12.5 mg took the face off my head. Yes I slept but 20 hours later am still looking for my face, that is, I am hungover with mild cognitive impairment so as not to be able to drive. For some the side effects aren't worth the sleep. I am one of those. It's back to the Ambien 10 mg or a new doctor."

2 / 10
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  • Littl...
  • March 30, 2012

Phenergan (promethazine) for Nausea/Vomiting "I have been using Phenergan to treat nausea for years. I have frequent and severe nausea associated with abdominal pain. It has been over three years and I am yet to get a diagnosis. I am grateful for this medicine. It is the only thing that stops the nausea. I would be crazy without this medicine! I was given Phenergan in the ER after I had a bad reaction to Zofran. It worked so well I asked the Doctor to send me home with a prescription for it. At my last ER visit they told me they were out of Phenergan and that it was in short supply. I was given Bentyl instead. That also gave me a bad reaction. I do without nausea medicine in the hospital if they do not have Phenergan."

10 / 10
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  • Anonymous
  • Taken for less than 1 month
  • April 24, 2019

For Nausea/Vomiting "I was prescribed this for morning sickness. It certainly did relieve the nausea, but it knocked me out for six-eight hours shortly after taking it. I tried taking it before bed instead of during the day and slept really well, but still felt really groggy in the morning and kept falling back to sleep. In the end I moved to another med so I didn't feel so drowsy."

6 / 10
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17 Report

Frequently asked questions

  • Mano
  • Taken for 1 to 2 years
  • August 6, 2018

For Opiate Adjunct "After fracturing my clavicle in six places in a football scrum, I have suffered chronic pain. One of the fractures (where bone is no longer present) never repaired itself. I am currently on Oxycodone 20mg four times a day, Codeine 60mg four times a day and Lyrica (Pregabalin) 300mg twice a day. Was told by my Specialist to go to the chemist and get a box of Promethazine and take 25mg-50mg four times a day to see if it potentiated my analgesia. My goodness has it been a life changer. I am almost at a pain score of 0. Also, given that it is an antihistamine, it removes the itch associated with opiate use. A solid 10/10."

10 / 10
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  • Prome...
  • Taken for 1 to 2 years
  • March 12, 2016

For Nausea/Vomiting "I have had stomach issues due to my GERD and have tried Zofran and it didn't work at all. My DR then had me try out Promethazine for whenever I feel nauseous when my GERD acts up or I eat something that makes me feel sick and it's gone within 15-20 minutes. It hasn't made me tired, but sometimes I will get a very quick blurred vision spell which I was warned about. But I love it.. it really helps me out"

10 / 10
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Are you taking this medicine?

  • Jano
  • Taken for less than 1 month
  • October 10, 2020

For Sedation "Have taken promethazine for 3 nights, have been struggling to sleep for a couple months now. Has done nothing but give me a slight headache around my temples. If anything I feel like this has kept me awake."

1 / 10
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  • KPano
  • Taken for less than 1 month
  • May 22, 2020

For Sedation "Tried promethazine these to help with restless legs syndrome at night and think it made it worse. Not sure whether it was me waiting for them to work that made me more agitated or the tablet. Stopped taking them after 3 nights of hardly any sleep."

1 / 10
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  • skinn...
  • Taken for less than 1 month
  • August 9, 2018

For Sedation "This is the worst drug I've ever taken. Headaches, tongue swelling, eye lids swelling and a rash on them. I've got sore legs, sore arms and feel so ill. My doctor took me off Zoplicone and replaced it with this medicine I WOULDNT RECOMEND THIS DRUG TO ANYBODY OR GIVE TO A PATIENT WITH MENTAL HEALTH PROBLEMS"

1 / 10
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  • JohnC
  • Taken for 1 to 6 months
  • February 22, 2018

For Sedation "This drug works for insomnia but it seems to have a very long half life and I feel groggy the next day, plus it also gives me depression which can linger for at least a couple of days after taking it, depression is a common side effect of antihistamines especially the strongest anticholinergic ones like Promethazine/Phenergan."

5 / 10
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  • Sleep...
  • September 20, 2017

For Sedation "I was given 25mg to take night time. I found myself waiting hours before it kicks in. Everyone said the next day how well I looked however my brain was a bit fuzzy the following day. I shall use this drug to create a sleep routine and then only use it sparingly for emergencies of sleeplessness. I found myself sleeping through the night for the first time in years."

5 / 10
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  • seasi...
  • Taken for 1 to 2 years
  • February 4, 2017

For Sedation "Before you take this for sleep, particularly if you are giving it to children, please read information about withdrawal. I was taking it for Prozac induced insomnia. Coming off Prozac was easy. Coming off phenergan is awful. It has been likened to coming off opiates. I am on day two. I am hoping by Monday it will be out of system and I can restart my life drug free."

7 / 10
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  • DeDe
  • Taken for 5 to 10 years
  • October 28, 2018

For Nausea/Vomiting "I have had generic phenergan for years. Anxiety and migraines for years. Then came compazine and I thought I was going to jump out of my skin, agitation, aggressive definitely not for me. Then Zofran which did absolutely nothing! Was diagnosed with chronic pain syndrome after cervical discectomy with fusion, then another surgery. Had s pain pump inserted and I was vomitin like there was no tomorrow. My pain doctor prescribed promethazine and a muscle relaxer and said the combination would stop the nausea and the promethazine would also work well at reducing the pain. I’m long passed being drowsy and it is a miracle drug for me. I wouldn’t have any quality of life without it."

10 / 10
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  • MedSc...
  • November 11, 2013

For Nausea/Vomiting "Promethazine has worked wonders for me on many occasions when suffering from moderate to severe nausea. Due to the somewhat intense sedation at higher doses, I usually opt for Zofran (ondansetron) for mild nausea associated with the onset of a mild migraine. That being said, promethazine is the better option if you are already severely nauseous or vomiting. If taking it for the first time, be wary of doing anything that could be dangerous while being impaired, as it is notorious for being very sedating. Also, from personal experience, I learned that I cannot tolerate this medication IV. It was given to me as an opiate adjunct and caused me to become aggressive, disoriented, and extremely restless. Overall, I still recommend it."

8 / 10
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  • Sam
  • Taken for less than 1 month
  • March 27, 2019

For Nausea/Vomiting "This is a very potent drug. I'll say that. Highly effective for nausea and works very quickly, and that was what I was taking it for, so I'm giving it a 9. The one point deduction is for the weird side effects. Definitely makes you super drowsy, and I also experienced mood swings, crying jags, and what almost felt like hot flashes. But they're preferable to the extreme nausea, so... weigh your options."

9 / 10
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  • Anonymous
  • June 30, 2010

Phenergan (promethazine) for Nausea/Vomiting "This drug is truly amazing! Nobody can figure out why I've been so nauseated and vomiting the last 2 years. When I have a really bad episode I take promethazine and don't throw up or feel nearly as sick. I don't even get the sleepy side effect it just makes everything better."

10 / 10
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  • Verti...
  • June 10, 2016

For Vertigo "I take this medication with another pill for my Ménière's Disease. Once my vertigo is in play I get severely nauseated and vomit. With this drug once an attack comes on I take it immediately. It not only calms me down but makes the nausea go away almost completely it's a God send."

10 / 10
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  • Unique
  • Taken for less than 1 month
  • July 3, 2015

For Nausea/Vomiting "I take this now and I'm pregnant. It's the only medication that has completely helped my nausea. The only bad thing is it makes me extremely tired and that's not good because I'm a stay at home mother of a very energized 3 year old."

10 / 10
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  • Mike
  • Taken for 1 to 6 months
  • March 27, 2022

Phenergan (promethazine) for Sedation "Take 50mg at night to help me sleep as it takes away the anxiety. It works a treat. I'm very sedated and calm after 1 hour and can sleep 8 hours. Only down side I seem to crave sugar foods like chocolate so I tend to binge (can eat whole entire packet of biscuits in 10 mins)"

9 / 10
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  • Yarbdor
  • December 9, 2018

Phenergan (promethazine) for Urticaria "Chronic Hives - 25mg works well after desloratidine ceased working for me. Side effects of sedation, lethargy, falling asleep very quickly (sometimes inappropriately), dry eyes & mouth. (If I was working and not retired, the side effects may not have been manageable)"

7 / 10
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  • Doc...
  • Taken for 5 to 10 years
  • October 21, 2016

For Light Sedation "I have been taking Promethazine 25mg tablets as needed for nausea for about 5 years. 1 pill would completely take away my nausea, even if I had the flu. However, the first time taking 1 pill knocked me out. You can build up a tolerance fairly quickly if you take them daily. I also have taken 1 to 2 pills to sleep through the night if im off work the next day because they make me groggy for a few hours the next morning. They don't make me feel "out of it" like Xanax and I have never developed any type of addiction to them either."

10 / 10
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  • A t g
  • Taken for less than 1 month
  • February 28, 2022

Phenergan (promethazine) for Nausea/Vomiting "Do not use this medication for anyone over 60. My mother was given this in the hospital for mild nauseous feeling. I think they thought she would be sedated by it. She is elderly. This drug put her into a terrible state of hallucinations delirium and all around restlessness for about 8 hours. It’s awful. She would have been better off with tums. Be aware of all the side affects."

1 / 10
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  • Nikki...
  • October 19, 2015

For Nausea/Vomiting "I was nauseous and in pain for 3 months straight couldn't hold anything down at all. Dr could not figure out what was wrong, I lost 70lbs in that three months from not eating anything but applesauce and water. Two years ago I was diagnosed with GERD acid reflux and a hiatus hernia, still with the meds they put me on I was unable to hold food down maybe toast rice water etc. Finally my Dr introduced me to promethazine, it has been my best friend I take it probably 3 to 4 times a week and everytime within 30~40min it works fabulous. I would recommend it to anyone who has nauseous/vomiting issues."

10 / 10
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  • JNL
  • March 17, 2009

Phenergan (promethazine) for Nausea/Vomiting "I had a very serious vomiting problem with my first pregnancy. I had to be hospitalized and then put on an IV at home for fluids. When I was about two months pregnant with my second child I was given promethazine, and it was the only thing that kept me from the same issues as the first pregnancy. I was still sick everyday, and I was still vomiting sporadically. However, I was able to actually eat and drink and gain weight. My son was born fine. Now I am pregnant with my third and have started on it earlier than the second pregnancy. I was not aware that the effects of the drug on unborn children is unknown. My doctor had told me it was safe. Hopefully this next baby will be fine as well."

9 / 10
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  • Oli
  • January 22, 2020

Phenergan (promethazine) for Light Sedation "This does the job for stressful periods of insomnia, but I wouldn’t recommend it if you have something important to wake up for the next morning - one 25mg pill makes me feel drowsy for hours after waking"

7 / 10
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  • Predi...
  • April 17, 2010

Phenergan (promethazine) for Nausea/Vomiting "Phenergan is an excellent medication for sleep and nausea. It also helps with pain associated with headaches. Phenergan allows your stomach to feel much better and your pain to slightly subside. It's a good night's rest guaranteed. Phenergan had absolutely no side effects, aside from sedative effects...which were welcomed after I had been so ill with nausea and vomiting. A Take it, feel better, and get back to life."

10 / 10
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31 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.