Zepbound: How to Inject Demonstration

Zepbound is a GIP and GLP-1 receptor agonist that is used in addition to exercise and a reduced-calorie diet for long-term weight management in certain adults.

It’s available as a pre-filled, single-dose pen (also called an autoinjector) and a single-dose vial. It comes in six different doses, and is injected once a week under the skin.

If you have been prescribed Zepbound, the brand name for tirzepatide, you should have received training from your healthcare professional on how to give yourself the injection safely. In this video, we will review step-by–step how to give yourself a Zepbound injection using the pre-filled pen.

Before using Zepbound, review the Instructions for Use provided with your prescription. When you are ready to inject your dose, gather your materials. You will need: Your Zepbound pen, a piece of gauze or a cotton ball, an alcohol swab, and a sharps container.

Now that you are ready to inject your dose, let’s review the steps on how to inject your Zepbound pen.

Step 1: Check your pen to make sure the medication isn’t expired, frozen, or cloudy. It should look colorless to slightly yellow, and shouldn’t have particles in it.
Step 2: Wash your hands with soap and water.
Step 3: Choose your injection site. If you are injecting Zepbound by yourself, you can inject it into your stomach, 2 inches away from your belly button or into your thigh. If someone else is helping you, they can inject it into the back of your upper arm. Make sure to change your injection site each week. Clean your chosen injection site with an alcohol swab.
Step 4: While the pen is locked, pull off the gray base cap and throw it away.
Step 5: Place the clear base flat against your skin at the injection site, then twist the top of the pen to the “unlocked” position.
Step 6: While holding the pen firmly against your skin, press and hold the purple injection button for up to 10 seconds. You will hear a click signaling the injection has started, and a second loud click when the injection is completed. The injection is done when you can see the gray plunger.
Step 7: Remove the pen from your skin and place it directly into a sharps container.
Step 8: If you have any bleeding at the injection site, you can press a cotton ball or gauze over the injection site until the bleeding has stopped.

If you have any questions about how to inject Zepbound, contact your healthcare provider or the manufacturer, Lilly.