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Tylosin

This page contains information on Tylosin for veterinary use.
The information provided typically includes the following:

Tylosin Indications
Warnings and cautions for Tylosin
Direction and dosage information for Tylosin

Tylosin

This treatment applies to the following species:

Manufacturer: AgriPharm

INJECTION

Antibiotic - Sterile

200 mg/mL

For use in animals only.

NADA 138-955, Approved by FDA

Description

Tylosin Injection is available in a concentration of 200 mg/mL tylosin base. The product is recommended for intramuscular injection only in beef cattle, nonlactating dairy cattle and swine.

Each mL Contains:

	200 mg/mL
Tylosin Base	200.0 mg
Propylene Glycol	50% v/v
Benzyl Alcohol	4% v/v
Water for Injection	q.s.

Tylosin Indications

Tylosin Injection is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot-rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Actinomyces pyogenes in beef cattle and nonlactating dairy cattle.

In swine, Tylosin Injection is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; and acute swine dysentery associated with with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae when followed by appropriate medication in the drinking water and/or feed.

Dosage and Administration

For intramuscular injection only.

Beef Cattle and Nonlactating Dairy Cattle - Inject intramuscularly 8 mg per pound of body weight (1 mL per 25 pounds) once daily. Treatment should be continued for 24 hours after symptoms of the disease have stopped, not to exceed 5 days. Do not inject more than 10 mL per injection site.

Swine - Inject intramuscularly 4 mg per pound of body weight (1 mL per 50 pounds) twice daily. Treatment should be continued for 24 hours after symptoms of the disease have stopped, not to exceed 3 days. Do not inject more than 5 mL per injection site.

Side Effects

Side effects consisting of edema of the rectal mucosa, anal protrusion, diarrhea, erythema and pruritus have been observed in some hogs following the use of tylosin. Discontinuation of treatment effected an uneventful recovery.

Tylosin Caution

Do not mix Tylosin Injection with other injectable solutions as this may cause precipitation of the active ingredients. Do not administer to horses or other equine species. Injection of tylosin in equines has been fatal.

Precautions

Adverse reactions, including shock and death may result from overdosage in baby pigs. Do not attempt injection into pigs weighing less than 25 pounds (0.5 mL). It is recommended that Tylosin Injection 50 mg/mL be used in pigs weighing less than 25 pounds.

If tylosin-medicated drinking water is used as follow-up treatment for swine dysentery, the animal should thereafter receive feed containing 40 to 100 grams of tylosin per ton for 2 weeks to assure depletion of tissue residues.

Warning

Discontinue use in cattle 21 days before slaughter. Discontinue use in swine 14 days before slaughter. Do not use in lactating dairy cattle. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Store at 72°F (22°C) or below.

How Supplied

Tylosin Injection, 200 mg/mL is available in 250 mL and 500 mL vials. The 500 mL size is for use via automatic syringe only.

Keep out of reach of children.

Mfd in USA

Manufactured by: Boehringer Ingelheim Vetmedica, Inc, St. Joseph, MO 64506 U.S.A.

Manufactured for: AGRIPHARM, Westlake, TX 76262 USA

Distributed by: Dealer Distributions of America

Net Contents:
250 mL	42312	687917L-00-0205
500 mL	42310	687919L-00-0205

NAC No.: 14571412

AGRIPHARM
822 7TH STREET, SUITE 605, GREELEY, CO, 80631

Telephone:

817-859-3000

Every effort has been made to ensure the accuracy of the Tylosin information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.