Pancrezyme

Manufacturer: Virbac

Tablet 425 mg

Powder

WHOLE PANCREAS

NOT AN EXTRACT

NOT ENTERIC COATED

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Keep tightly closed in a cool, dry place.

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Each 425 mg tablet contains:

Each 2.8 grams (1 teaspoonful) of powder contains:

Description

PANCREZYME^® Powder and Tablets are activated whole raw pancreas; a pancreatic enzyme concentrate of porcine origin containing standardized amylase, protease and lipase activities plus esterases, peptidases, nucleases and elastase.

Background Information:

The most recognized causes of Exocrine Pancreatic Insufficiency (EPI) in the canine include chronic pancreatitis that is secondary to an acute episode, pancreatic acinar atrophy, and less commonly, congenital hypoplasia. EPI may also be caused by obstruction of the pancreatic duct as a result of pancreatic or extrapancreatic masses.

Dogs that develop acute pancreatitis usually recover, but are subject to exacerbations of the chronic inflammatory process that may persist. Acute pancreatitis that resolves is typically not causative of EPI unless it leads to a chronic condition where greater than 90% of the exocrine function is lost. Signs of the chronic disease form are similar to those of acute pancreatitis but are usually less severe. Steatorrhea, diarrhea, weight loss and increased appetite characterize the digestive impairment caused by failure of pancreatic exocrine secretion. Thus, maldigestion is a relatively late event in the pathogenesis of chronic pancreatitis. Transient episodes of fetid diarrhea may occur at the time of an acute exacerbation and may be caused by a temporary reduction of pancreatic exocrine secretion. However, food engorgement or the ingestion of fatty food often precipitates an exacerbation of chronic pancreatitis. The character of the food, rather than the absence of pancreatic enzymes, may cause the diarrhea. The veterinarian should not be too concerned about whether the pancreatic lesion is acute or chronic. His primary concern should be to recognize pancreatic inflammatory disease and begin treatment. The differentiation of acute and chronic pancreatitis is then made on the basis of history, and is of importance in advancing a prognosis.

Currently, pancreatic acinar atrophy is thought to be an immune mediated condition with no specific treatment other than enzyme replacement once exocrine function is completely lost. Acinar Hypoplasia is a congenital condition that is typically diagnosed in certain predisposed breeds at a very young age and requires life long treatment.

Pancrezyme Indications

As a digestive aid: replacement therapy where digestion of protein, carbohydrate and fat is inadequate due to exocrine pancreatic insufficiency.

Precautions

Discontinue use in animals with symptoms of sensitivity.

Treatment in Acute and Chronic Pancreatitis:

The most important aspect of the treatment of acute pancreatitis is initiation of vigorous therapy aimed at combating pain and shock, restoring blood volume, blood pressure and renal function while reducing pancreatic secretions and combating secondary infection of necrotic tissue. In cases of chronic pancreatitis, where exocrine function is lost or significantly diminished, replacement therapy will most likely be given for the duration of the animal’s life. Three daily feedings of a bland and easily digested diet containing sufficient quantities of good quality proteins and carbohydrates and low levels of fat are recommended. PANCREZYME Powder and Tablets are given with each meal at a dosage level sufficient to keep the feces normal.

Dosage and Administration

PANCREZYME Tablets are administered before each meal; PANCREZYME Powder is added to moistened dog food (canned or dry).

Thorough mixing is necessary to bring the enzymes into close contact with the food particles. Incubation at room temperature for 15-20 minutes before feeding appears to enhance the digestive process. Frequent feeding, at least 3 times daily is important.

Usual dosage:

Dogs: 2-3 tablets or 3/4-1 teaspoonful (2.8 g/teaspoonful) with each meal.

Cats: 1/2-1 tablet or 1/4-3/4 teaspoonful (2.8 g/teaspoonful) with each meal.

NOTE: No one regimen will be successful for every patient. The above dosage should be adjusted according to the severity of the pancreatic exocrine insufficiency, the dosage should be increased until desired results are obtained.

Each 2.8 grams (1 teaspoonful) contains sufficient pancreatic enzymes to digest (in vitro):

260 g fat

388 g protein

460 g starch

Each tablet contains sufficient pancreatic enzymes to digest (in vitro): 33 g fat

57 g protein

64 g starch

How Supplied

PANCREZYME Tablets - 425 mg each in bottles of 500 NDC 051311-825-50.

PANCREZYME Powder - Bottles of 8 ounce NDC 051311-821-08 and 12 ounce NDC 051311-821-12.

Mfg. for: Virbac AH, Inc., Fort Worth, TX 76137

For more Information Call 1-800-338-3659

Revised 10/12

301596-02

CPN: 1023077.1