Chorulon

Company: Intervet/Merck Animal Health

Approved by FDA under NADA# 140-927

FOR ANIMAL USE ONLY

Chorulon Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

CHORULON^® is a freeze-dried preparation of chorionic gonadotropin (human Chorionic Gonadotropin or hCG) for intramuscular administration after reconstitution. When reconstituted with the accompanying sterile diluent, each 10 mL vial contains 10,000 I.U. chorionic gonadotropin (equivalent to 10,000 USP Units chorionic gonadotropin) and 10 mg mannitol, with mono- and disodium phosphate to adjust the pH of the solution.

Action

Chorionic gonadotropin has luteinizing hormone-like activity with little or no follicle stimulating or estrogenic activity.

Chorulon Indications

COWS: CHORULON^® is indicated for intramuscular use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.

FINFISH: CHORULON^® is indicated for use as an aid in improving spawning function in male and female brood finfish.

Chorulon Dosage And Administration

To reconstitute, transfer the contents of one vial of sterile diluent into one vial of freeze-dried powder. The resulting 10 mL of CHORULON^® contains 10,000 I.U. chorionic gonadotropin.

COWS: The contents of one vial (10 mL) of reconstituted CHORULON^® should be administered as a single deep intramuscular injection. Dosage may be repeated in 14 days if the animal’s behavior or rectal examination of the ovaries indicates the necessity for retreatment.

FINFISH: CHORULON^® should be administered via intramuscular injection just ventral to the dorsal fin for one (1) to three (3) injections. Any single injection should be administered, depending on the fish species, at a dose of 50 to 510 I.U./lb body weight (bw) for males and 67 to 1816 I.U./lb bw for females. Depending on body weight and dose administered, it may be necessary to divide the dose among two or more injection sites to avoid injecting a large volume at a single site.

Summaries of doses tested in representative fish species are contained within the following tables. The dose of CHORULON^® to be used in other species of finfish may differ from those species listed in the tables, but should fall within the suggested range of 50 to 510 I.U./lb bw for males and 67 to 1816 I.U./lb bw for females.

Table 1: Tested Fish Species/Dose Combinations Found to be Effective

Footnotes: 1, nt = not tested

Table 2: Tested Fish Species/Dose Combinations Found to be Safe

Adverse Reactions

Chorionic gonadotropin is a protein. In the unlikely event of an anaphylactic reaction, epinephrine should be administered. The administration of an antihistamine may also be indicated.

Residue Warnings

No withdrawal period is required for cows or brood finfish treated according to label directions. The total dose administered (all injections combined) should not exceed 25,000 I.U. (25 mL) per fish in fish intended for human consumption.

Storage And Handling Precautions

Store at or below room temperature, 77°F (25°C). Keep out of reach of children. Once reconstituted, CHORULON^® should be used immediately. Unused solution should be disposed of properly and not stored for future use.

How Supplied

CHORULON^® is supplied in cartons containing five vials of freeze-dried powder and five 10 mL vials of sterile diluent. Order Code No. CH-475-1.

Intervet Inc., d/b/a Merck Animal Health, Rahway, NJ 07065

Manufactured by:

Intervet International GmbH, Unterschleissheim, Germany

Copyright© 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved.

Rev. 6/2023

395398 R2

CPN: 1047314.3