Actogain 45

(ractopamine hydrochloride Type A medicated article)

For Use in Feeds For Cattle Fed in Confinement for Slaughter Only

Type A Medicated Article

Active Drug Ingredient: Ractopamine hydrochloride - 45.4 g per lb (100 g per kg)

Important: Must be thoroughly mixed into feeds before use. Follow label directions.

Indication: Complete Feed: For increased rate of weight gain, improved feed efficiency and increased carcass leanness in cattle fed in confinement for slaughter during the last 28 to 42 days on feed.

Top Dress Feed: For increased rate of weight gain and improved feed efficiency in cattle fed in confinement for slaughter during the last 28 to 42 days on feed.

Note: Carcass leanness effects are not an approved indication for use when feeding ractopamine by Top Dress Feeding methods.

Complete Feed

^a Based on 90% Dry Matter Basis

^a The effect of ractopamine on parameters listed in this table is supported by data generated at the doses tested in the clinical field efficacy trials.

NC = No Change, ↑ = increased, ↓ = decreased

^b Steers Only

^c Reduction indicates an improvement in USDA Yield Grade.

Top Dress Feed

^a Based on 90% Dry Matter Basis

Inert Ingredients: Ground corncobs.

Mixing Directions (Complete Feed): Thoroughly mix Actogain 45 Type A Medicated Article in a ton of appropriate feed ingredients or diluents according to the table below to obtain the proper concentration in the Type B Medicated Feed (maximum 4,920 g/ton). The following table gives examples of how some Type B Medicated Feed concentrations can be prepared:

^a Actogain 45 contains 45.4g ractopamine hydrochloride per pound

^b Based on 90% Dry Matter Basis

Thoroughly mix Actogain 45 Type A Medicated Article in a ton of complete cattle feed according to the table below to obtain the proper concentration in the Type C Medicated Feed. Prepare an intermediate pre-blend of the premix prior to mixing in a complete feed. Thoroughly mix the required amount in a convenient quantity of feed ingredients then add to the remaining feed ingredients to make one ton of complete feed.

^a Actogain 45 contains 45.4g ractopamine hydrochloride per pound

^b Based on 90% Dry Matter Basis

Mixing Directions (Liquid Type B Feeds): Thoroughly mix Actogain 45 Type A Medicated Article in a ton of appropriate feed ingredients or diluents according to the table below to obtain the proper concentration in the Type B Medicated Feed (maximum 2300 g/ton).

Maintain supplement pH to 4.5 to 7.5. For stored liquid Type B medicated feeds containing ractopamine, recirculate immediately prior to use for not less than 10 minutes, moving not less than 1% of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not in use.

The following table gives examples of how some Type B Medicated Feed concentrations can be prepared:

^a Actogain 45 contains 45.4g ractopamine hydrochloride per pound

Mixing Directions for preparing Type C Medicated Top Dress Feed: Thoroughly mix Actogain 45 Type A Medicated Article in a ton of appropriate feed ingredients or diluents according to the table below to obtain the proper concentration in the Type C Medicated Feed (maximum 800 g/ton). The following table gives examples of how some Type C Medicated Top Dress Feed concentrations can be prepared:

^a Actogain 45 contains 45.4g ractopamine hydrochloride per pound

^b Based on 90% Dry Matter Basis

Directions for Use (Complete Feed): Feed continuously to cattle fed in confinement for slaughter as the sole ration for the last 28 to 42 days on feed.

Directions for Use (Type C Medicated Top Dress Feed): Feed continuously to cattle fed in confinement for slaughter a Type C Medicated Feed containing up to a maximum of 800 g/ton ractopamine (see mixing direction table) to provide 70 to 400 mg per head per day for the last 28 to 42 days on feed. Type C Medicated Top Dress feed must be fed in a minimum of 1.0 lb per head per day to provide 70 to 400 mg per head per day.

Actogain 45 Caution

Not for animals intended for breeding.

Warning Withdrawal Period: No withdrawal period is required when used according to labeling. NOT FOR HUMAN USE

Store below 25°C (77°F), excursions permitted to 40°C (104°F). Avoid Moisture. Expiration Date and Lot Number are printed on the bag. Not to be used after the expiry date.

Restricted Drug (California) - Use Only as Directed

Approved by FDA under ANADA # 200-548

Distributed by:

Zoetis Inc., Kalamazoo, MI 49007

To report suspected adverse events, for technical assistance or obtain a copy of the Safety Data Sheet, contact Zoetis Inc. at 1-888-963-8471. For additional information about adverse experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

CPN: 3690367.3