Osteoarthritis of the Knee

You might want to give it a try (unless your doctor has suggested you avoid it). If you take less than the maximum recommended dosage (see the medication label) and it works well for you, that may be all you need to do for now. Ask your doctor about the safety and advisability of acetaminophen in your particular situation.

Have you tried a non-steroidal anti-inflammatory drug (NSAID), such as ibuprofen or naproxen?

Yes, I have tried NSAIDs.

No, I have not tried NSAIDs.