Zyrtec-D Side Effects

Generic name: cetirizine / pseudoephedrine

Medically reviewed by Drugs.com. Last updated on Sep 15, 2023.

Note: This document provides detailed information about Zyrtec-D Side Effects associated with cetirizine / pseudoephedrine. Some dosage forms listed on this page may not apply specifically to the brand name Zyrtec-D.

Applies to cetirizine / pseudoephedrine: oral tablet extended release.

Common side effects of Zyrtec-D

Some side effects of cetirizine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• sleepiness or unusual drowsiness, extreme tiredness

Less common side effects

• dry mouth
• weakness

Rare side effects

• dizziness
• sore throat

Serious side effects of Zyrtec-D

Along with its needed effects, cetirizine/pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following symptoms of overdose occur while taking cetirizine / pseudoephedrine:

Symptoms of Overdose

• changes in mood, irrational behavior, depersonalization hallucinations
• convulsions (seizures)
• extreme sleepiness or unusual drowsiness
• fast, slow, pounding, or irregular heartbeat or pulse
• feeling anxious
• giddiness
• headache
• irritability
• muscle weakness or tenderness
• nausea
• restlessness
• shallow, irregular, fast, or slow breathing
• sleeplessness or trouble in sleeping
• abdominal and/or chest pain
• thirst

Check with your doctor as soon as possible if any of the following side effects occur while taking cetirizine / pseudoephedrine:

Rare side effects

• Breathing, troubled
• back, leg, or stomach pain
• blurred vision
• bloody, cloudy, or dark urine, sudden decrease in amount of urine
• black, tarry stools, diarrhea, light-colored stools
• confusion
• dizziness, feeling faint, or lightheaded
• fever or chills
• increased blood pressure
• rapid weight gain
• skin rash or hives
• swelling of face, mouth, throat, fingers, glands, feet, and/or lower legs
• stillbirth
• twitching, twisting, or uncontrolled repetitive movements of the face
• sudden sweating
• vomiting blood, bleeding gums, nosebleeds, unusual bleeding or bruising
• pale or yellow eyes or skin
• unusual tiredness or weakness

For healthcare professionals

Applies to cetirizine / pseudoephedrine: oral tablet extended release.

General adverse events

The manufacturer has not provided adverse event information.^[Ref]

Further information

Zyrtec-D side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer