Zurnai Side Effects
Generic name: nalmefene
Medically reviewed by Drugs.com. Last updated on Mar 21, 2024.
Note: This document contains side effect information about nalmefene. Some dosage forms listed on this page may not apply to the brand name Zurnai.
Applies to nalmefene: nasal spray. Other dosage forms:
Serious side effects of Zurnai
Along with its needed effects, nalmefene (the active ingredient contained in Zurnai) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nalmefene:
More common
- Blurred vision
- dizziness
- fast, pounding, or irregular heartbeat or pulse
- headache
- nervousness
- pounding in the ears
Less common
- Agitation
- anxiety
- confusion
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- increased sweating
- unusual tiredness or weakness
Rare
- Chest pain or discomfort
- decrease in frequency of urination
- decrease in urine volume
- difficulty in passing urine
- discouragement
- feeling sad or empty
- irritability
- lack of appetite
- lack of interest or pleasure
- lightheadedness, dizziness, or fainting
- muscle twitching or jerking
- nervousness
- painful urination
- rhythmic movement of muscles
- shakiness in the legs, arms, hands, or feet
- sleepiness or unusual drowsiness
- slow or irregular heartbeat
- trembling or shaking of the hands or feet
- trouble breathing
- trouble concentrating
- trouble sleeping
Incidence not known
- Blue lips and fingernails
- blurred vision
- body aches
- coughing that sometimes produces a pink frothy sputum
- diarrhea
- excessive crying
- fever
- goosebumps
- headache
- increase in blood pressure
- increased or excessive unconscious or jerking movements
- nausea
- no blood pressure or pulse
- pale skin
- pounding in the ears
- restlessness
- runny nose
- seizures
- shivering
- sneezing
- stomach cramps
- stopping of the heart
- swelling in the legs and ankles
- unconsciousness
- vomiting
- yawning
Other side effects of Zurnai
Some side effects of nalmefene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Feeling of warmth
- redness of the face, neck, arms and occasionally, upper chest
Less common
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- change in taste
- decreased appetite
- loss of taste
- stuffy nose
- throat and mouth pain
- throat irritation
Rare
- Dry mouth
- dryness or soreness of the throat
- hoarseness
- tender, swollen glands in the neck
- trouble in swallowing
- voice changes
For Healthcare Professionals
Applies to nalmefene: injectable solution, nasal spray.
Gastrointestinal
Gastrointestinal side effects have occurred commonly, with nausea and vomiting observed in 18% and 9%, respectively, of treated patients. Diarrhea and dry mouth have been reported in less than 1% of patients.[Ref]
Cardiovascular
Cardiovascular adverse effects including tachycardia, hypertension, hypotension, vasodilation, bradycardia, and arrhythmia have been reported in 5% or fewer of treated patients.[Ref]
Nervous system
Nervous system side effects including postoperative pain, dizziness, headache, fever, and chills have been reported in less than 5% of treated patients. Somnolence, depression, agitation, nervousness, tremor, confusion, and myoclonus have been reported in less than 1% of patients.[Ref]
Nalmefene administration may precipitate acute and extended withdrawal symptoms in opioid-dependent patients.[Ref]
Respiratory
Respiratory side effects have included pharyngitis (less than 1%). Pulmonary edema is an uncommon effect that has occurred with nalmefene (the active ingredient contained in Zurnai) administration.[Ref]
A 21-year-old male with no significant past medical history had decreased respirations following an exploratory laparotomy for presumed appendicitis. The patient developed acute pulmonary edema after receiving 75 mcg nalmefene in 25 mcg increments over 10 minutes. Clinical resolution of symptoms was prompt after supplemental oxygen and furosemide. It took 36 hours for the chest X-ray to improve.[Ref]
Dermatologic
Dermatologic side effects have infrequently included pruritus (less than 1%).[Ref]
Genitourinary
Genitourinary side effects have included rare reports of urinary retention (less than 1%).[Ref]
Other
Other side effects including fever (3%) and chills (1%) have been reported.
More about Zurnai (nalmefene)
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: antidotes
- Breastfeeding
Patient resources
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Professional resources
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Related treatment guides
References
1. Barsan WG, Seger D, Danzl DF, Ling LJ, Bartlett R, Buncher R, Bryan C (1989) "Duration of antagonistic effects of nalmefene and naloxone in opiate- induced sedation for emergency department procedures." Am J Emerg Med, 7, p. 155-61
2. (2001) "Product Information. Revex (nalmefene)." OHMEDA
3. Kaplan JL, Marx JA, Calabro JJ, GinShaw SL, Spiller JD, Spivey WL, Gaddis GM, Zhao N, Harchelroad FP (1999) "Double-blind, randomized study of nalmefene and naloxone in emergency department patients with suspected narcotic overdose." Ann Emerg Med, 34, p. 42-50
4. Rosen DA, Morris JL, Rosen KR, et al. (2000) "Nalmefene to prevent epidural narcotic side effects in pediatric patients: a pharmacokinetic and safety study." Pharmacotherapy, 20, p. 745-9
5. Henderson CA, Reynolds JE (1997) "Acute pulmonary edema in a young male after intravenous nalmefene." Anesth Analg, 84, p. 218-9
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.