Vyepti Side Effects

Generic name: eptinezumab

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 10, 2025.

Note: This document provides detailed information about Vyepti Side Effects associated with eptinezumab. Some dosage forms listed on this page may not apply specifically to the brand name Vyepti.

Applies to eptinezumab: intravenous solution.

Common side effects of Vyepti

Some side effects of eptinezumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• headache
• muscle aches
• sore throat
• stuffy or runny nose

Incidence not known

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Serious side effects of Vyepti

Along with its needed effects, eptinezumab (the active ingredient contained in Vyepti) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking eptinezumab:

Less common side effects

• chest tightness
• fast heartbeat
• feeling of warmth
• fever
• hives, itching, skin rash
• hoarseness
• irritation
• joint pain, stiffness or swelling
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
• redness of the skin
• redness of the face, neck, arms and occasionally, upper chest
• swelling of the eyelids, face, lips, hands, or feet
• trouble breathing or swallowing

Incidence not known

• cough
• dizziness
• unusual tiredness or weakness

For healthcare professionals

Applies to eptinezumab: intravenous solution.

General adverse events

The most commonly reported adverse reactions were nasopharyngitis and hypersensitivity.^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity (including angioedema, urticaria, flushing, rash
• Postmarketing reports: Anaphylactic reactions (including hypotension and respiratory difficulties)

and pruritus)

Immunologic

• Very common (10% or more): Anti-drug antibodies (up to 20.6%)

Local

• Uncommon (less than 2%): Infusion-site reactions including extravasation

Other

• Common (1% to 10%): Fatigue

Respiratory

• Common (1% to 10%): Nasopharyngitis
• Frequency not reported (infusion-related respiratory symptoms): Nasal congestion, rhinorrhea, throat irritation, cough, sneezing, dyspnea

Frequently asked questions

• What are the new drugs for the treatment of migraine?
• How long does it take Vyepti to work?
• Does Vyepti cause weight gain?
• Can Vyepti cause fatigue?
• How long do Vyepti infusions take?
• How is Vyepti different from Aimovig?

Further information

Vyepti side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer