Vivaglobin Side Effects
Generic name: immune globulin subcutaneous
Medically reviewed by Drugs.com. Last updated on May 12, 2024.
Note: This document provides detailed information about Vivaglobin Side Effects associated with immune globulin subcutaneous. Some dosage forms listed on this page may not apply specifically to the brand name Vivaglobin.
Applies to immune globulin subcutaneous: subcutaneous solution.
Important warnings
This medicine can cause some serious health issues
Subcutaneous route (solution)
Warning: Thrombosis. Thrombosis may occur with immune globulin products, including immune globulin-hipp.
Risk factors may include: advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling central vascular catheters, hyperviscosity, and cardiovascular risk factors.
Thrombosis may occur in the absence of known risk factors.For patients at risk of thrombosis, administer immune globulin-hipp at the minimum dose and infusion rates practicable.
Ensure adequate hydration in patients before administration.
Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.
Serious side effects of Vivaglobin
Along with its needed effects, immune globulin subcutaneous (the active ingredient contained in Vivaglobin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking immune globulin subcutaneous:
More common
Incidence not known
- agitation
- anxiety
- blistering, peeling, or loosening of the skin
- bloody, black, or tarry stools
- blue lips, fingernails, or skin
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest discomfort or pain
- collection of blood under the skin
- confusion
- coughing that sometimes produces a pink frothy sputum
- decreased awareness or responsiveness
- decreased urine output
- deep, dark purple bruise
- depression
- diarrhea
- difficult, fast, noisy breathing
- difficulty swallowing
- fast, pounding, or irregular heartbeat or pulse
- headache, severe and throbbing
- high fever
- hives or welts, itching
- hostility
- increased sweating
- irregular, fast or slow, or shallow breathing
- irritability
- joint or muscle pain
- lightheadedness or fainting
- loss of consciousness
- muscle twitching
- nervousness
- pain in the chest, groin, or legs, especially the calves
- pain, redness, or swelling of the skin
- painful or difficult urination
- pale skin
- pounding in the ears
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- seizures
- severe sleepiness
- slow heartbeat
- slurred speech
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- stiff neck or back
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- swelling of the legs, ankles, or hands
- swollen glands
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
- trouble breathing
- unexplained bleeding or bruising
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- upper stomach pain
- vision changes
Other side effects of Vivaglobin
Some side effects of immune globulin subcutaneous may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- skin abrasion
Incidence not known
- back pain
- difficulty in moving
- feeling of warmth
- increased sweating
- loss or thinning of hair
- muscle cramping
- pain in the arms or legs
- redness of the face, neck, arms, and occasionally, upper chest
- skin discoloration
- stomach distension
- swollen joints
For healthcare professionals
Applies to immune globulin subcutaneous: subcutaneous solution.
General
The most common adverse events were local reactions, headache, diarrhea, fatigue, back pain, nausea, pain in extremity, and cough.[Ref]
Local
- Very common (10% or more): Local reactions (49%), infusion site erythema, injection site pain
- Common (1% to 10%): Injection site swelling, injection site bruising
- Uncommon (0.1% to 1%): Injection site edema
- Postmarketing reports: Infusion site ulcer[Ref]
Nervous system
- Very common (10% or more): Headache (29.2%)
- Common (1% to 10%): Migraine, dizziness, somnolence
- Uncommon (0.1% to 1%): Burning sensation
- Postmarketing reports: Tremor, paresthesia[Ref]
Gastrointestinal
- Very common (10% or more): Diarrhea (18.8%), nausea (12.2%), vomiting, abdominal pain
- Common (1% to 10%): Abdominal pain upper, abdominal discomfort, abdominal pain lower[Ref]
Dermatologic
Hypersensitivity
- Common (1% to 10%): Hypersensitivity
- Postmarketing reports: Allergic-anaphylactic reactions (e.g. swollen face or tongue and pharyngeal edema, pyrexia, chills, dizziness, hypertension or changes in blood pressure, malaise)[Ref]
Cardiovascular
- Common (1% to 10%): Hypotension
- Rare (less than 0.1%): Hot flush
- Postmarketing reports: Chest discomfort (including chest pain), tachycardia[Ref]
Other
- Very common (10% or more): Fatigue (12.5%)
- Common (1% to 10%): Pain in extremity, pain, contusion, hematoma
- Uncommon (0.1% to 1%): Anti-GAD antibody positive
- Rare (less than 0.1%): Hematoma[Ref]
Respiratory
- Very common (10% or more): Cough (10.4%)
- Common (1% to 10%): Oropharyngeal pain
- Rare (less than 0.1%): Nasopharyngitis
- Postmarketing reports: Dyspnea, laryngospasm[Ref]
Musculoskeletal
- Very common (10% or more): Pain in extremity
- Common (1% to 10%): Back pain, arthralgia, chills, myalgia[Ref]
Hematologic
- Uncommon (0.1% to 1%): Coombs direct test positive[Ref]
References
1. (2006) "Product Information. Vivaglobin (immune globulin subcutaneous)." *ZLB Bioplasma Inc
2. (2018) "Product Information. Hizentra (immune globulin subcutaneous)." CSL Behring LLC
3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
4. Cerner Multum, Inc. "Australian Product Information."
5. (2018) "Product Information. Cuvitru (immune globulin subcutaneous)." Baxter Healthcare Corporation
More about Vivaglobin (immune globulin subcutaneous)
- Check interactions
- Compare alternatives
- Reviews (5)
- Latest FDA alerts (1)
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: immune globulins
Patient resources
Other brands
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Professional resources
Other brands
Hizentra, Xembify, Cuvitru, Cutaquig
Related treatment guides
Further information
Vivaglobin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.