Vaxneuvance Side Effects

Generic name: pneumococcal 15-valent conjugate vaccine

Medically reviewed by Drugs.com. Last updated on Jan 7, 2024.

Note: This document provides detailed information about Vaxneuvance Side Effects associated with pneumococcal 15-valent conjugate vaccine. Some dosage forms listed on this page may not apply specifically to the brand name Vaxneuvance.

Applies to pneumococcal 15-valent conjugate vaccine: intramuscular suspension.

Common side effects of Vaxneuvance

Some side effects of pneumococcal 15-valent conjugate vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• decreased appetite
• difficulty in moving
• headache
• joint pain or swelling
• muscle aches, cramps, pains, or stiffness
• unusual tiredness or weakness

Serious side effects of Vaxneuvance

Along with its needed effects, pneumococcal 15-valent conjugate vaccine (the active ingredient contained in Vaxneuvance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pneumococcal 15-valent conjugate vaccine:

Less common side effects

• fever

For healthcare professionals

Applies to pneumococcal 15-valent conjugate vaccine: intramuscular suspension.

General adverse events

The most commonly reported side effects included localized pain, irritability, elevated body temperature (from at least 38C to less than 39C), and somnolence.^[Ref]

Dermatologic

• Common (1% to 10%): Urticaria^[Ref]

Local

• Very common (10% or more): Localized pain (up to 75.8%), localized erythema (up to 21.6%), localized swelling (up to 21.7%), localized induration (up to 14.1%)
• Uncommon (0.1% to 1%): Injection site urticaria^[Ref]

Metabolic

• Very common (10% or more): Decreased appetite (up to 19.4%)^[Ref]

Musculoskeletal

• Very common (10% or more): Myalgia (up to 28.8%), arthralgia (up to 12.7%)^[Ref]

Nervous system

• Very common (10% or more): Somnolence (up to 40.7%), headache (up to 26.5%)^[Ref]

Other

• Very common (10% or more): Elevated body temperature (at least 38C to less than 39C [up to 50.8%]), fatigue (up to 34.3%)
• Common (1% to 10%): Elevated body temperature (at least 39C to less than 40C), elevated body temperature (at least 40C)^[Ref]

Psychiatric

• Very common (10% or more): Irritability (up to 55.1%)
• Common (1% to 10%): Extreme distress, unable to do unusual activities^[Ref]

Frequently asked questions

• Prevnar 20 vs Pneumovax 23: Which vaccine is right for you?
• How long does a pneumonia vaccine shot last?

Further information

Vaxneuvance side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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