Uptravi Side Effects

Generic name: selexipag

Medically reviewed by Drugs.com. Last updated on May 29, 2024.

Note: This document provides detailed information about Uptravi Side Effects associated with selexipag. Some dosage forms listed on this page may not apply specifically to the brand name Uptravi.

Applies to selexipag: oral tablet.

Other dosage forms:

• intravenous powder for solution

Common side effects of Uptravi

Some side effects of selexipag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• decreased appetite
• diarrhea
• feeling of warmth
• headache
• joint pain
• muscle aching or cramping
• muscle pains or stiffness
• nausea
• pain in the jaw, arms, or legs
• rash
• redness of the face, neck, arms, and occasionally, upper chest
• swollen joints
• vomiting

Serious side effects of Uptravi

Along with its needed effects, selexipag (the active ingredient contained in Uptravi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selexipag:

Incidence not known

• blue lips and fingernails
• chest pain
• coughing that sometimes produces a pink frothy sputum
• difficult, fast, noisy breathing
• increased sweating
• pale skin
• swelling in the legs and ankles

For healthcare professionals

Applies to selexipag: intravenous injection, oral tablet.

General adverse events

The most frequently reported side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 42%), nausea (up to 34%), vomiting (up to 18%)
• Common (1% to 10%): Abdominal pain, dyspepsia, abdominal discomfort
• Frequency not reported: Ascites^[Ref]

Cardiovascular

• Very common (10% or more): Flushing (up to 12%), sinus tachycardia (up to 11.3%)
• Common (1% to 10%): Hypotension
• Frequency not reported: Hot flush
• Postmarketing reports: Symptomatic hypotension^[Ref]

Dermatologic

• Very common (10% or more): Rash (11%)
• Common (1% to 10%): Urticaria, erythema^[Ref]

Endocrine

• Common (1% to 10%): Hyperthyroidism, thyroid stimulating hormone decreased^[Ref]

Hematologic

• Common (1% to 10%): Anemia, hemoglobin decreased^[Ref]

Local

• Frequency not reported (injection): Infusion-site reactions (erythema, redness, pain, swelling)

Metabolic

• Common (1% to 10%): Appetite decreased^[Ref]

Musculoskeletal

• Very common (10% or more): Jaw pain (26%), pain in extremity (up to 17%), myalgia (up to 16%), arthralgia (up to 11%)
• Common (1% to 10%): Musculoskeletal pain, neck pain
• Frequency not reported: Bone pain^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 65%)
• Frequency not reported: Burning sensation^[Ref]

Ocular

• Common (1% to 10%): Eye pain, retinal disorder^[Ref]

Oncologic

• Common (1% to 10%): Malignancy^[Ref]

Other

• Common (1% to 10%): Asthenia, pyrexia, pain, influenza, weight decreased^[Ref]

Renal

• Frequency not reported: Acute renal failure

Respiratory

• Very common (10% or more): Nasopharyngitis (13%)
• Common (1% to 10%): Nasal congestion
• Frequency not reported: Pulmonary veno-occlusive disease^[Ref]

Frequently asked questions

• What is the drug Uptravi used for?

Further information

Uptravi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer