Typhoid Vaccine, Inactivated Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 14, 2024.

Applies to typhoid vaccine, inactivated: intramuscular solution.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Dizziness or passing out.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Upset stomach.
• Headache.
• Irritation where the shot is given.
• Feeling tired or weak.
• Muscle pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

For healthcare professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule.

General adverse events

The most common adverse events were injection site reactions.^[Ref]

Local

• Very common (10% or more): Tenderness (98%), pain (56%), induration (18%), soreness (13%), erythema (11%)
• Common (1% to 10%): Swelling
• Very rare (less than 0.01%): Edema^[Ref]

Local reactions usually resolved within 48 hours of vaccination.^[Ref]

Other

• Very common (10% or more): Malaise (37%), fatigue (38%), feverish (subjective) (11.1%)
• Common (1% to 10%): Fever of 100F or greater, decreased activity, elevated oral temperature, general aches
• Postmarketing reports: Asthenia, flu-like episode^[Ref]

Nervous system

• Very common (10% or more): Headache (27%)
• Postmarketing reports: Syncope without convulsions, loss of consciousness, tremor, vasovagal syncope in response to injection^[Ref]

Hypersensitivity

• Postmarketing reports: Anaphylaxis/anaphylactoid reactions including shock, serum sickness, allergic-type reactions such as pruritus, rash, urticaria, angioedema, difficulty breathing, or hypotension^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, diarrhea, vomiting
• Postmarketing reports: Abdominal pain^[Ref]

Dermatologic

• Common (1% to 10%): Itching
• Very rare (less than 0.01%): Urticaria, rash^[Ref]

Musculoskeletal

• Common (1% to 10%): Myalgia
• Postmarketing reports: Arthralgia, cervical pain, polyarthritis^[Ref]

Hematologic

• Postmarketing reports: Lymphadenopathy, neutropenia^[Ref]

Ocular

• Postmarketing reports: Bilateral retinitis^[Ref]

Renal

• Postmarketing reports: Glomerulonephritis^[Ref]

Respiratory

• Postmarketing reports: Asthma^[Ref]

Further information

Typhoid vaccine, inactivated side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer