Skip to main content

Tucatinib Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 28, 2023.

Applies to tucatinib: oral tablet.

Serious side effects of tucatinib

Along with its needed effects, tucatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tucatinib:

More common

  • anxiety
  • bloody nose
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • clay colored stools
  • dark urine
  • decreased or loss of appetite
  • dizziness
  • fever
  • headache
  • mood or mental changes
  • nausea and vomiting
  • nervousness
  • pale skin
  • pounding in the ears
  • severe diarrhea
  • skin rash, itching
  • slow or fast heartbeat
  • swelling of the feet or lower legs
  • stomach pain or tenderness
  • trouble breathing
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness of the arms, hands, legs, or feet
  • yellow eyes or skin

Less common

  • muscle spasm or jerking of all extremities
  • loss of bladder control
  • seizures
  • sudden loss of consciousness

Other side effects of tucatinib

Some side effects of tucatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • back pain
  • chest tightness
  • constipation
  • difficulty in moving
  • flushing
  • loss of weight
  • muscle pain or stiffness
  • pain in the joints
  • redness, swelling, pain of the skin
  • scaling of the skin on the hands and feet
  • swelling or inflammation of the mouth
  • ulceration of the skin

For healthcare professionals

Applies to tucatinib: oral tablet.

Dermatologic

Gastrointestinal

Hematologic

Hepatic

Metabolic

Musculoskeletal

Renal

Respiratory

References

1. (2020) "Product Information. Tukysa (tucatinib)." Seattle Genetics Inc

2. (2023) "Product Information. Tukysa (tucatinib)." Seagen Inc, v04

Frequently asked questions

Further information

Tucatinib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.