Spiriva Respimat Side Effects

Generic name: tiotropium

Medically reviewed by Drugs.com. Last updated on Apr 10, 2024.

Note: This document provides detailed information about Spiriva Respimat Side Effects associated with tiotropium. Some dosage forms listed on this page may not apply specifically to the brand name Spiriva Respimat.

Applies to tiotropium: inhalation capsule, inhalation spray.

Serious side effects of Spiriva Respimat

Along with its needed effects, tiotropium (the active ingredient contained in Spiriva Respimat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tiotropium:

More common side effects

• arm, back, or jaw pain
• chest pain or discomfort
• chest tightness or heaviness
• fast or irregular heartbeat
• nausea
• sweating
• trouble breathing

Less common side effects

• cough
• difficulty with swallowing
• dizziness
• hives, itching, or skin rash
• painful blisters on the trunk of body
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• tightness in the chest
• unusual tiredness or weakness

Rare side effects

• fainting
• fast, pounding, or irregular heartbeat or pulse
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Other side effects of Spiriva Respimat

Some side effects of tiotropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• belching
• bladder pain
• bloody or cloudy urine
• body aches or pain
• chest pain
• chills
• congestion
• cough
• difficult, burning, or painful urination
• dry mouth
• dryness of the throat
• ear congestion
• fever
• frequent urge to urinate
• headache
• heartburn
• hoarseness
• indigestion
• loss of voice
• lower back or side pain
• pain or tenderness around the eyes and cheekbones
• runny or stuffy nose
• sneezing
• sore throat
• stomach discomfort, upset, or pain
• tender, swollen glands in the neck
• voice changes

Less common side effects

• bloody nose
• blurred vision
• bone pain
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• canker sores
• difficulty having a bowel movement (stool)
• discouragement
• feeling sad or empty
• flushed, dry skin
• fruit-like breath odor
• increased hunger
• increased thirst
• increased urination
• irritability
• lack of appetite
• leg pain
• loss of interest or pleasure
• muscle pain
• nausea
• painful or difficult urination
• sore mouth or tongue
• sores, ulcers, or white spots on the lips or tongue or inside the mouth
• sweating
• swelling or inflammation of the mouth
• tiredness
• trouble concentrating
• trouble sleeping
• unexplained weight loss
• vomiting

Incidence not known

• bloating
• change in vision
• diarrhea
• red skin

For healthcare professionals

Applies to tiotropium: inhalation aerosol, inhalation capsule.

General adverse events

The most commonly reported adverse reaction was dry mouth, usually mild and often resolved during continued treatment.

Other reactions consistent with possible anticholinergic effects included constipation, tachycardia, blurred vision, glaucoma (new onset or worsening), dysuria, and urinary retention.^[Ref]

Respiratory

• Very common (10% or more): Pharyngitis (11.5%)
• Common (1% to 10%): Respiratory tract infection, cough, sinusitis, rhinitis, epistaxis, dysphonia, chest pain, laryngitis
• Rare (less than 0.1%): Epistaxis, bronchospasm,
• Postmarketing reports: Pharyngolaryngeal pain, throat irritation, hoarseness^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations, angina pectoris (including aggravated angina pectoris)
• Uncommon (0.1% to 1%): Atrial fibrillation
• Rare (less than 0.1%): Palpitations, supraventricular tachycardia, tachycardia^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Rare (less than 0.1%): Angioneurotic edema, urticaria, skin infection, skin ulcer, dry skin^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth, constipation, gastroesophageal reflux, oropharyngeal candidiasis, dyspepsia, abdominal pain, vomiting
• Uncommon (0.1% to 1%): Dysphagia, gingivitis, intestinal obstruction including ileus paralytic, stomatitis (including ulcerative stomatitis)
• Rare (less than 0.1%): Dental caries, glossitis
• Frequency not reported: Nausea
• Postmarketing reports: Oral candidiasis, throat irritation, mouth ulceration^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection
• Uncommon (0.1% to 1%): Urinary retention, dysuria^[Ref]

Hypersensitivity

• Common (1% to 10%): Allergic reactions
• Rare (less than 0.1%): Angioedema, hypersensitivity (including immediate reactions)
• Frequency not reported: Anaphylactic reactions^[Ref]

Metabolic

• Common (1% to 10%): Hypercholesterolemia, hyperglycemia
• Frequency not reported: Dehydration^[Ref]

Musculoskeletal

• Common (1% to 10%): Myalgia, arthritis, skeletal pain, leg pain
• Frequency not reported: Join swelling^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, paresthesia
• Uncommon (0.1% to 1%): Headache, insomnia, taste disorder^[Ref]

Ocular

• Common (1% to 10%): Cataract
• Uncommon (0.1% to 1%): Blurred vision
• Rare (less than 0.1%): Glaucoma, intraocular pressure increased^[Ref]

Other

• Common (1% to 10%): Edema, infections, moniliasis, influenza-like symptoms, herpes zoster^[Ref]

Psychiatric

• Common (1% to 10%): Depression^[Ref]

Frequently asked questions

• Can asthma inhalers cause a sore throat?

Further information

Spiriva Respimat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer