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Sincalide Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 12, 2024.

Applies to sincalide: intravenous powder for solution.

Common side effects of sincalide

Some side effects of sincalide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • nausea
  • stomach discomfort or pain

Less common side effects

  • diarrhea
  • feeling of warmth
  • increased sweating
  • redness of the face, neck, arms, and occasionally, upper chest
  • sneezing
  • urge to defecate
  • vomiting

Serious side effects of sincalide

Along with its needed effects, sincalide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sincalide:

Less common side effects

  • blurred vision
  • chest tightness
  • confusion
  • cough
  • difficulty swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • headache
  • hives, itching, skin rash
  • loss of consciousness
  • nervousness
  • numbness of the face, lips, and eyes
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • slow or fast heartbeat
  • stomach cramping
  • sweating
  • unusual tiredness or weakness
Managing side effects (general information)

For healthcare professionals

Applies to sincalide: injectable powder for injection, intravenous powder for injection.

General adverse events

Reactions to sincalide are usually mild and of short duration. Adverse reactions including vomiting, flushing, sweating, rash, hypotension, hypertension, shortness of breath, urge to defecate, headache, diarrhea, sneezing, and numbness were less than 1%. Dizziness was reported in approximately 2% of patients. These manifestations are usually attenuated by a slower injection rate.[Ref]

Gastrointestinal

Gastrointestinal side effects have included abdominal discomfort or pain and nausea. Rapid IV injection of 0.04 mcg sincalide per kg would be expected to cause transient abdominal cramping. These side effects are usually manifestations of the physiologic action of the drug, including delayed gastric emptying and increased intestinal motility. These side effects occurred in approximately 20% of patients but they are not to be construed as necessarily indicating an abnormality of the biliary tract unless there is other clinical or radiologic evidence of disease.[Ref]

References

1. (2010) "Product Information. Kinevac (sincalide)." Bristol-Myers Squibb

Further information

Sincalide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer