SAMe Side Effects

Generic name: s-adenosylmethionine

Note: This document provides detailed information about SAMe Side Effects associated with s-adenosylmethionine. Some dosage forms listed on this page may not apply specifically to the brand name SAMe.

Applies to s-adenosylmethionine: oral capsule.

Important warnings This medicine can cause some serious health issues

You should not use SAMe if you have bipolar depression, anxiety disorder, or take medicine for depression.

Do not use SAMe if you have used an MAO inhibitor in the past 14 days.

A dangerous drug interaction could occur.

MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Although not all side effects are known, SAMe is thought to be likely safe for most adults when used as directed.

Common side effects may include:

• changes in hair color;

• headache, dizziness;

• feeling anxious or nervous;

• loss of appetite, vomiting, nausea, upset stomach;

• dry mouth;

• diarrhea, constipation;

• increased sweating; or

• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Further information

SAMe side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer