Pralidoxime Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 22, 2024.

Applies to pralidoxime: injection powder for solution.

Serious side effects of pralidoxime

Along with its needed effects, pralidoxime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pralidoxime:

More common side effects

• blurred or double vision
• change in near or distance vision
• difficult or rapid breathing
• difficulty in focusing the eyes
• difficulty with speaking
• dizziness
• fast, pounding, or irregular heartbeat or pulse
• muscle stiffness or weakness
• pain at the injection site (after injection into a muscle)

Incidence not known

• deep or fast breathing with dizziness
• numbness of the feet, hands, and around the mouth

Other side effects of pralidoxime

Some side effects of pralidoxime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• drowsiness
• headache
• nausea

For healthcare professionals

Applies to pralidoxime: intravenous powder for injection.

Cardiovascular adverse events

• Frequency not reported: Tachycardia, increased systolic and diastolic blood pressure^[Ref]

Musculoskeletal

• Frequency not reported: Muscular weakness^[Ref]

Nervous system

• Frequency not reported: Drowsiness^[Ref]

Respiratory

• Frequency not reported: Hyperventilation^[Ref]

Ocular

• Frequency not reported: Blurred vision, diplopia, impaired accommodation^[Ref]

Gastrointestinal

• Frequency not reported: Nausea^[Ref]

Metabolic

• Frequency not reported: Transient elevations of creatine phosphokinase

Hepatic

• Frequency not reported: Elevations in SGOT and/or SGPT enzymes^[Ref]

SGOT and SGPT levels returned to normal after about 2 weeks.^[Ref]

Local

• Frequency not reported: Pain at the injection site^[Ref]

Mild to moderate pain at the injection site occurs 40 to 60 minutes after intramuscular injection.^[Ref]

Further information

Pralidoxime side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer