Panobinostat Side Effects

Medically reviewed by Drugs.com. Last updated on May 2, 2024.

Applies to panobinostat: oral capsule.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Severe diarrhea has been reported with panobinostat.

Monitor for diarrhea, institute antidiarrheal treatment, interrupt therapy, then reduce the dose or discontinue panobinostat if necessary for severe diarrhea.

Severe and fatal cardiac ischemic events, severe arrhythmias, and ECG changes have occurred in patients receiving panobinostat, and electrolyte abnormalities may exacerbate arrhythmias.

A baseline ECG and electrolyte panel is recommended, along with periodic monitoring during treatment as clinically indicated.

Serious side effects of panobinostat

Along with its needed effects, panobinostat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking panobinostat:

More common side effects

• abdominal or stomach pain or tenderness
• black, tarry stools
• bloating or swelling of the face, arms, hands, lower legs, or feet
• clay colored stools
• confusion
• cough or sore throat
• dark or bloody urine
• decreased appetite
• decreased frequency or amount of urine
• dizziness, faintness, or lightheadedness especially when getting up suddenly from a lying or sitting position
• fast, irregular, pounding, or racing heartbeat or pulse
• fever, chills, or sweating
• headache
• increased thirst
• itching or skin rash
• loss of appetite
• lower back or side pain
• muscle spasms or twitching
• nausea or vomiting
• nervousness
• painful or difficult urination
• pinpoint red spots on the skin
• pounding in the ears
• rapid breathing
• seizures
• severe diarrhea
• slow or fast heartbeat
• swelling of the face, fingers, feet, or lower legs
• tingling of the hands or feet
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss
• yellow eyes or skin

Less common side effects

• chest pain or discomfort
• coughing up blood
• difficulty with swallowing
• increased menstrual flow or vaginal bleeding
• nosebleeds
• pain in the shoulders, arms, jaw, or neck
• paralysis

Other side effects of panobinostat

Some side effects of panobinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• belching or passing gas
• change or loss in taste
• depressed mood
• dry mouth
• hair loss
• heartburn or indigestion
• hoarseness or husky voice
• fatigue or feeling lethargic
• redness of the skin

For healthcare professionals

Applies to panobinostat: oral capsule.

Gastrointestinal adverse events

• Very common (10% or more): Diarrhea (68%), nausea (36%), vomiting (26%)
• Common (1% to 10%): Abdominal pain, dyspepsia, gastritis, cheilitis, abdominal distension, dry mouth, flatulence, colitis, gastrointestinal pain

Cardiovascular

• Very common (10% or more): T-wave abnormalities (40%), ST-segment depression (22%), arrhythmia (12%)
• Common (1% to 10%): Palpitations, hypotension, hypertension, orthostatic hypotension
• Uncommon (0.1% to 1%): Cardiac ischemic events^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (97%), lymphopenia (82%), leukopenia (81%), neutropenia (75%), anemia (62%)
• Common (1% to 10%): Grade 3/4 hemorrhage

Immunologic

• Very common (10% or more): Severe infections (31%)
• Common (1% to 10%): Hepatitis B

Hepatic

• Common (1% to 10%): Increased blood alkaline phosphatase
• Frequency not reported: Hepatic dysfunction (primarily aminotransferase and total bilirubin elevations)

Metabolic

• Very common (10% or more): Hypocalcemia (67%), hypoalbuminemia (63%), hypophosphatemia (63%), hypokalemia (52%), hyponatremia (49%), hyperphosphatemia (29%), decreased appetite (28%), hypermagnesemia (27%), hyperbilirubinemia (21%), decreased weight (12%)
• Common (1% to 10%): Hyperglycemia, dehydration, fluid retention, hypomagnesemia

Dermatologic

• Common (1% to 10%): Skin lesions, rash, erythema

Endocrine

• Common (1% to 10%): Hypothyroidism

Genitourinary

• Common (1% to 10%): Urinary incontinence, hyperuricemia

Musculoskeletal

• Common (1% to 10%): Joint swelling

Nervous system

• Common (1% to 10%): Dizziness, headache, syncope, tremor, dysgeusia

Other

• Very common (10% or more): Fatigue (60%), peripheral edema (29%), pyrexia (26%)
• Common (1% to 10%): Chills

Psychiatric

• Common (1% to 10%): Insomnia

Renal

• Very common (10% or more): Increased blood creatinine (41%)
• Common (1% to 10%): Renal failure, increased blood urea, decreased glomerular filtration rate

Respiratory

• Common (1% to 10%): Cough, dyspnea, respiratory failure, rales, wheezing

Further information

Panobinostat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer