Palopegteriparatide Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 10, 2024.

Applies to palopegteriparatide: subcutaneous solution.

Important warnings This medicine can cause some serious health issues

Palopegteriparatide may affect calcium levels in the blood.

Tell your doctor if you have nausea, vomiting, dizziness, feeling thirsty, muscle spasms or contractions, numbness or tingly feeling around your mouth, or in your fingers and toes, depression, problems with thinking or memory, irregular heart rhythm, or seizures.

Call your doctor at once if you have any pain that does not go away or a hard lump (induration) under the skin that is tender to touch or swelling under your skin.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• seizures;

• pain that does not go away;

• itchy, rash, hives;

• depression, problems with thinking or memory;

• irregular heart rhythm;

• low blood pressure (feeling like you might pass out);

• hard lump (induration) under the skin that is tender to touch; or

• muscle spasms or contractions, numbness or tingly feeling around your mouth, or in your fingers and toes.

Common side effects may include:

• headache;

• back pain;

• diarrhea;

• sore throat;

• confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss;

• pain, bruising, swelling, or irritation where the medicine was injected; or

• drop in blood pressure or feeling light-headed when standing up.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to palopegteriparatide: subcutaneous solution.

General adverse events

Adverse reactions occurring in at least 5% of patients included elevated albumin-corrected serum calcium, injection site reactions, vasodilatory signs and symptoms, headache, diarrhea, back pain, hypercalcemia, and oropharyngeal pain.^[Ref]

Cardiovascular

• Very common (10% or more): Vasodilatory signs and symptoms (28%)

Gastrointestinal

• Very common (10% or more): Diarrhea (10%)

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions such as anaphylaxis, angioedema, and urticaria have been observed with parathyroid hormone analogs

Immunologic

• Common (1% to 10%): Anti-drug antibodies

Local

• Very common (10% or more): Injection-site reactions such as bruising, erythema, and rash (39%)

Metabolic

• Very common (10% or more): Elevated albumin-corrected serum calcium greater than 10.6 mg/dL (54.1%), elevated albumin-corrected serum calcium greater than 12 mg/dL (13.1%)
• Common (1% to 10%): Hypercalcemia, symptomatic hypercalcemia

Musculoskeletal

• Common (1% to 10%): Back/flank/spinal pain

Nervous system

• Very common (10% or more): Headache (21%)

Oncologic

• Postmarketing reports: Osteosarcoma (with use of teriparatide)

Respiratory

• Common (1% to 10%): Oropharyngeal pain

Further information

Palopegteriparatide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer