Skip to main content

Pain Clear Paracetamol Side Effects

Generic name: acetaminophen

Medically reviewed by Drugs.com. Last updated on Nov 22, 2024.

Note: This document provides detailed information about Pain Clear Paracetamol Side Effects associated with acetaminophen. Some dosage forms listed on this page may not apply specifically to the brand name Pain Clear Paracetamol.

Applies to acetaminophen: intravenous solution.

Other dosage forms:

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Prevent acetaminophen injection dosing errors, which may result in accidental overdose and death, by confirming that doses in milligrams (mg) are not confused with doses in milliliters (mL); that patients under 50 kg receive weight-based doses; that infusion pumps are programmed correctly; and that the total dose of acetaminophen from all routes and from all sources does not exceed daily limits.

Life-threatening cases of acute hepatic failure leading to liver transplant or death have been linked with acetaminophen use.

In most cases of hepatic injury, acetaminophen doses exceeded maximum daily limits and often involved the use of more than 1 acetaminophen-containing product.

Other side effects

Some side effects of acetaminophen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • trouble sleeping

Less common-Adults

Less common-Children

Serious side effects

Along with its needed effects, acetaminophen (the active ingredient contained in Pain Clear Paracetamol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking acetaminophen:

Less common-Adults

Less common-Children

Incidence not known

  • abdominal or stomach pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • difficulty with swallowing
  • flu-like symptoms
  • loss of appetite
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • right upper stomach tenderness
  • skin rash, itching, or hives
  • tightness in the chest
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen:

Symptoms of overdose

Managing side effects (general information)

For healthcare professionals

Applies to acetaminophen: compounding powder, intravenous solution, oral capsule, oral granule effervescent, oral liquid, oral powder, oral powder for reconstitution, oral suspension, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, rectal suppository.

General adverse events

In general, acetaminophen (the active ingredient contained in Pain Clear Paracetamol) is well-tolerated when administered in therapeutic doses. The most commonly reported adverse reactions have included nausea, vomiting, constipation. Injection site pain and injection site reaction have been reported with the IV product.[Ref]

Hepatic

Gastrointestinal

Hypersensitivity

Hematologic

Dermatologic

Respiratory

Cardiovascular

Metabolic

Nervous system

Musculoskeletal

Psychiatric

Genitourinary

Local

Ocular

Other

References

1. "Multum Information Services, Inc. Expert Review Panel"

2. Zimmerman HJ, Maddrey WC (1995) "Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure." Hepatology, 22, p. 767-73

3. Gursoy M, Haznedaroglu IC, Celik I, Sayinalp N, Ozcebe OI, Dundar SV (1996) "Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity." Ann Pharmacother, 30, p. 762-5

4. Kurtovic J, Riordan SM (2003) "Paracetamol-induced hepatotoxicity at recommended dosage." J Intern Med, 253, p. 240-3

5. Vitols S (2003) "Paracetamol hepatotoxicity at therapeutic doses." J Intern Med, 253, p. 95-8

6. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA (1985) "Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen." Arch Intern Med, 145, p. 2019-23

7. O'Dell JR, Zetterman RK, Burnett DA (1986) "Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic." JAMA, 255, p. 2636-7

8. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB (1986) "Acetaminophen hepatotoxicity in alcoholics." Ann Intern Med, 104, p. 399-404

9. Minton NA, Henry JA, Frankel RJ (1988) "Fatal paracetamol poisoning in an epileptic." Hum Toxicol, 7, p. 33-4

10. Keaton MR (1988) "Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion." South Med J, 81, p. 1163-6

11. Shriner K, Goetz MB (1992) "Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med, 93, p. 94-6

12. Keays R, Harrison PM, Wendon JA, et al. (1991) "Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial." BMJ, 303, p. 1026-9

13. Rumore MM, Blaiklock RG (1992) "Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity." J Pharm Sci, 81, p. 203-7

14. Mofenson HC, Caraccio TR, Nawaz H, Steckler G (1991) "Acetaminophen induced pancreatitis." Clin Toxicol, 29, p. 223-30

15. Kumar S, Rex DK (1991) "Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics." Arch Intern Med, 151, p. 1189-91

16. Block R, Jankowski JA, Lacoux P, Pennington CR (1992) "Does hypothermia protect against the development of hepatitis in paracetamol overdose?" Anaesthesia, 47, p. 789-91

17. Brotodihardjo AE, Batey RG, Farrell GC, Byth K (1992) "Hepatotoxicity from paracetamol self-poisoning in Western Sydney: a continuing challenge." Med J Aust, 157, p. 382-5

18. Johnson GK, Tolman KG (1977) "Chronic liver disease and acetaminophen." Ann Intern Med, 87, p. 302-4

19. McJunkin B, Barwick KW, Little WC, Winfield JB (1976) "Fatal massive hepatic necrosis following acetaminophen overdose." JAMA, 236, p. 1874-5

20. Block R (1993) "Liver failure induced by paracetamol." BMJ, 306, p. 457

21. Wong V, Daly M, Boon A, Heatley V (1993) "Paracetamol and acute biliary pain with cholestasis." Lancet, 342, p. 869

22. Bray GP (1993) "Liver failure induced by paracetamol." BMJ, 306, p. 157-8

23. Lee WM (1994) "Acute liver failure." Am J Med, 96, p. 3-9

24. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B (1994) "Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency." Hepatology, 19, p. 1141-8

25. Cheung L, Potts RG, Meyer KC (1994) "Acetaminophen treatment nomogram." N Engl J Med, 330, p. 1907-8

26. Hartleb M (1994) "Do thyroid hormones promote hepatotoxicity to acetaminophen?" Am J Gastroenterol, 89, p. 1269-70

27. Smilkstein MJ, Douglas Dr, Daya MR (1994) "Acetaminophen poisoning and liver function." N Engl J Med, 331, p. 1310-1

28. Whitcomb DC (1994) "Acetaminophen poisoning and liver function." N Engl J Med, 331, p. 1311

29. Cheung L, Meyer KC (1994) "Acetaminophen poisoning and liver function." N Engl J Med, 331, p. 1311-2

30. Whitcomb DC, Block GD (1994) "Association of acetaminopphen hepatotoxicity with fasting and ethanol use." JAMA, 272, p. 1845-50

31. Bonkovsky HL (1995) "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA, 274, p. 301

32. Nelson EB, Temple AR (1995) "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA, 274, p. 301

33. Singer AJ, Carracio TR, Mofenson HC (1995) "The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction." Ann Emerg Med, 26, p. 49-53

34. Lee WM (1995) "Medical progress: drug-induced hepatotoxicity." N Engl J Med, 333, p. 1118-27

35. Settipane RA, Stevenson DD (1989) "Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma." J Allergy Clin Immunol, 84, p. 26-33

36. Van Diem L, Grilliat JP (1990) "Anaphylactic shock induced by paracetamol." Eur J Clin Pharmacol, 38, p. 389-90

37. Leung R, Plomley R, Czarny D (1992) "Paracetamol anaphylaxis." Clin Exp Allergy, 22, p. 831-3

38. Doan T, Greenberger PA (1993) "Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47- year-old woman." Ann Allergy, 70, p. 439-44

39. Kalyoncu AF (1994) "Acetaminophen hypersensitivity and other analgesics." Ann Allergy, 72, p. 285

40. Doan T (1994) "Acetaminophen hypersensitivity and other analgesics - response." Ann Allergy, 72, p. 285

41. Kawada A, Hiruma M, Noguchi H, Ishibashi A (1996) "Fixed drug eruption induced by acetaminophen in a 12-year-old girl." Int J Dermatol, 35, p. 148-9

42. Halevi A, BenAmitai D, Garty BZ (2000) "Toxic epidermal necrolysis associated with acetaminophen ingestion." Ann Pharmacother, 34, p. 32-4

43. Shoenfeld Y, Shaklai M, Livni E, Pinkhas J (1980) "Thrombocytopenia from acetaminophen." N Engl J Med, 303, p. 47

44. Bougie DW, Benito AI, Sanchez-Abarca LI, Torres R, Birenbaum J, Aster RH (2007) "Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen." Blood, 109, p. 3608-9

45. Thomas RH, Munro DD (1986) "Fixed drug eruption due to paracetamol." Br J Dermatol, 115, p. 357-9

46. Guccione JL, Zemtsov A, Cobos E, Neldner KH (1993) "Acquired purpura fulminans induced by alcohol and acetaminophen - successful treatment with heparin and vitamin-k." Arch Dermatol, 129, p. 1267-9

47. Filipe PL, Freitas JP, Decastro JC, Silva R (1995) "Drug eruption induced by acetaminophen in infectious mononucleosis." Int J Dermatol, 34, p. 220-1

48. Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K (1993) "Acetaminophen-induced eosinophilic pneumonia." Chest, 104, p. 291-2

49. Brown G (1996) "Acetaminophen-induced hypotension." Heart Lung, 25, p. 137-40

50. Koulouris Z, Tierney MG, Jones G (1999) "Metabolic acidosis and coma following a severe acetaminophen overdose." Ann Pharmacother, 33, p. 1191-4

Frequently asked questions

Further information

Pain Clear Paracetamol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer