Oxytrol Side Effects

Generic name: oxybutynin

Medically reviewed by Drugs.com. Last updated on Mar 26, 2024.

Note: This document provides detailed information about Oxytrol Side Effects associated with oxybutynin. Some dosage forms listed on this page may not apply specifically to the brand name Oxytrol.

Applies to oxybutynin: transdermal gel/jelly, transdermal patch extended release.

Other dosage forms:

• oral syrup, oral tablet, oral tablet extended release

Serious side effects of Oxytrol

Along with its needed effects, oxybutynin (the active ingredient contained in Oxytrol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxybutynin:

More common side effects

• bladder pain
• blistering, crusting, irritation, itching, or reddening of the skin
• bloody or cloudy urine
• burning, skin rash, swelling, soreness, redness, pain, itching, or irritation at the application site
• cracked, dry, or scaly skin
• difficult, burning, or painful urination
• frequent urge to urinate
• lower back or side pain
• unusually warm skin

Less common side effects

• diarrhea
• loss of appetite
• nausea
• stomach pain
• weakness

Incidence not known

• confusion as to time, place, or person
• holding false beliefs that cannot be changed by fact
• seeing, hearing, or feeling things that are not there
• unusual excitement, nervousness, or restlessness

Other side effects of Oxytrol

Some side effects of oxybutynin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• body aches or pain
• chills
• cough
• difficulty with breathing
• ear congestion
• headache
• loss of voice
• nasal congestion
• runny nose
• sneezing
• sore throat

Less common side effects

• back pain
• bloated feeling
• changes in vision
• constipation
• excess air or gas in the stomach or intestines
• feeling of fullness
• muscle aches
• passing gas
• sleepiness or unusual drowsiness

Incidence not known

• forgetfulness

For healthcare professionals

Applies to oxybutynin: oral solution, oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel.

General adverse events

The most common (incidence 5% or greater) adverse reactions were dry mouth, constipation, diarrhea, headache, somnolence, and dizziness.^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations
• Uncommon (0.1% to 1%): Cardiac arrhythmia tachycardia, vasodilation, hypertension, flushing
• Frequency not reported: Heat stroke^[Ref]

Dermatologic

• Very common (10% or more): Dry skin, pruritus
• Common (1% to 10%): Flushing, rash
• Frequency not reported: Angioedema, hypohidrosis^[Ref]

Endocrine

• Postmarketing reports: Decreased lactation^[Ref]

Gastrointestinal

• Very common (10% or more): Dry mouth (up to 72%), constipation (up to 15%), nausea
• Common (1% to 10%): Diarrhea, dyspepsia, abdominal pain, vomiting, flatulence, gastroesophageal reflux disease
• Uncommon (0.1% to 1%): Abdominal discomfort
• Frequency not reported: Pseudo-obstruction in patients at risk (elderly or patients with constipation and treated with other drugs that decrease intestinal motility), decreased GI motility^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity
• Frequency not reported: Anaphylactic reaction^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection, urinary hesitation, urinary retention, dysuria, increased post void retention
• Frequency not reported: Impotence, suppression of lactation, cystitis, aggravation of prostatic hypertrophy^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Fungal infection^[Ref]

Local

• Very common (10% or more): Application site pruritus (16.8%)
• Common (1% to 10%): Application site erythema, application site vesicles, application site rash, application site macules^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia, fluid retention^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Back pain^[Ref]

Nervous system

• Very common (10% or more): Dizziness (up to 17%), somnolence (up to 14%), headache, drowsiness, confusion
• Common (1% to 10%): Dysgeusia
• Uncommon (0.1% to 1%): Dysphagia, convulsions
• Frequency not reported: Cognitive disorders in elderly, convulsions, agitation, nightmares, anxiety, paranoia, symptoms of depression, hallucinations, asthenia, insomnia, restlessness, dependence to this drug (in patients with history of drug or substance abuse)^[Ref]

Ocular

• Common (1% to 10%): Blurred vision, dry eye, abnormal vision
• Uncommon (0.1% to 1%): Angle closure glaucoma
• Frequency not reported: Onset of narrow-angle glaucoma, mydriasis, intraocular hypertension, amblyopia, cycloplegia, decreased lacrimation^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Dysphonia, thirst
• Frequency not reported: Falls, accidental injury^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, nervousness
• Uncommon (0.1% to 1%): Hallucinations, confusional state, agitation, memory impairment
• Frequency not reported: Psychotic disorder, anxiety, nightmares, paranoia, abnormal behavior^[Ref]

Respiratory

• Common (1% to 10%): Cough, oropharyngeal pain, dry throat, nasal dryness
• Uncommon (0.1% to 1%): Upper respiratory tract infection, rhinitis, chest discomfort, hoarseness
• Rare (0.01% to 0.1%): Nasal congestion, throat irritation^[Ref]

Other

Concomitant use of oxybutynin (the active ingredient contained in Oxytrol) with carbamazepine and dantrolene has been associated with adverse events suggestive of carbamazepine toxicity, such as vomiting, drowsiness, confusion, unsteadiness, slurred speech, and nystagmus.

Further information

Oxytrol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer