Oxbryta Side Effects

Generic name: voxelotor

Medically reviewed by Drugs.com. Last updated on Oct 25, 2024.

Note: This document provides detailed information about Oxbryta Side Effects associated with voxelotor. Some dosage forms listed on this page may not apply specifically to the brand name Oxbryta.

Applies to voxelotor: oral tablet, oral tablet for suspension.

Common side effects of Oxbryta

Some side effects of voxelotor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• diarrhea
• headache
• nausea
• stomach pain

Serious side effects of Oxbryta

Along with its needed effects, voxelotor (the active ingredient contained in Oxbryta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking voxelotor:

Rare side effects

• black, tarry stools
• chest pain
• chills
• cough
• fever
• hives or welts, itching or skin rash
• painful or difficult urination
• redness of the skin
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling of the face
• swollen glands
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness

Incidence not known

• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• swelling around the eyes
• swelling of the eyelids

For healthcare professionals

Applies to voxelotor: oral tablet, oral tablet soluble.

General adverse events

The more commonly reported adverse reactions have included headache, diarrhea, abdominal pain, nausea, fatigue, rash, and pyrexia^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Serious hypersensitivity reactions
• Frequency not reported: Drug hypersensitivity

Clinical manifestations of serious hypersensitivity reactions may include generalized rash, urticaria, mild shortness of breath, mild facial swelling, and eosinophilia. Drug hypersensitivity has been reported in less than 10% of patients.

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 23%), abdominal pain (up to 23%; including abdominal pain, lower abdominal pain, and upper abdominal pain), nausea (up to 19%), vomiting (33%)

Dermatologic

• Very common (10% or more): Rash (up to 20%)

Rash includes terms of rash, urticaria, generalized rash, maculo-papular rash, pruritic rash, papular rash, erythematous rash, and vesicular rash.

Other

• Very common (10% or more): Fatigue (14%), pyrexia (up to 36%)

Nervous system

• Very common (10% or more): Headache (up to 32%)

Further information

Oxbryta side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer