Orserdu Side Effects

Generic name: elacestrant

Medically reviewed by Drugs.com. Last updated on Mar 19, 2025.

Note: This document provides detailed information about Orserdu Side Effects associated with elacestrant. Some dosage forms listed on this page may not apply specifically to the brand name Orserdu.

Applies to elacestrant: oral tablet.

Common side effects of Orserdu

Some side effects of elacestrant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• belching
• constipation
• decreased appetite
• diarrhea
• headache
• heartburn
• hot flush
• indigestion
• muscle or bone pain
• nausea
• stomach discomfort, upset, or pain
• unusual tiredness or weakness
• vomiting

Serious side effects of Orserdu

Along with its needed effects, elacestrant (the active ingredient contained in Orserdu) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

For healthcare professionals

Applies to elacestrant: oral tablet.

General adverse events

Very common adverse reactions (>10%) included musculoskeletal pain, nausea, increased cholesterol, increased AST, increased triglycerides, fatigue, decreased hemoglobin, vomiting, increased ALT, decreased sodium, increased creatinine, decreased appetite, diarrhea, headache, constipation, abdominal pain, hot flush, and dyspepsia.^[Ref]

Cardiovascular

• Very common (10% or more): Hot flushes (11%)
• Frequency not reported: Cardiac arrest, septic shock^[Ref]

Dermatologic

• Frequency not reported: Rash^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (35%), vomiting (19%), diarrhea (13%), constipation (12%), abdominal pain (11%), dyspepsia (10%)
• Frequency not reported: Diverticulitis, stomatitis, gastroesophageal reflux disease^[Ref]

Hematologic

• Very common (10% or more): Decreased hemoglobin (26%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (41%)^[Ref]

Metabolic

• Very common (10% or more): Increased cholesterol (30%), increased triglycerides (27%), hyponatremia (16%), decreased appetite (15%)^[Ref]

Psychiatric

• Frequency not reported: Insomnia^[Ref]

Hepatic

• Very common (10% or more): Increased aspartate aminotransferase (29%), increased alanine aminotransferase (17%)^[Ref]

Respiratory

• Frequency not reported: Dyspnea, cough^[Ref]

Other

• Very common (10% or more): Fatigue (26%)^[Ref]

Nervous system

• Very common (10% or more): Headache (12%)
• Frequency not reported: Dizziness^[Ref]

Renal

• Very common (10% or more): Increased creatinine (16%)^[Ref]

Further information

Orserdu side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer