Ongentys Side Effects

Generic name: opicapone

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 21, 2024.

Note: This document provides detailed information about Ongentys Side Effects associated with opicapone. Some dosage forms listed on this page may not apply specifically to the brand name Ongentys.

Applies to opicapone: oral capsule.

Serious side effects of Ongentys

Along with its needed effects, opicapone (the active ingredient contained in Ongentys) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking opicapone:

More common side effects

• twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

Less common side effects

• blurred vision
• confusion
• dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
• headache
• nervousness
• pounding in the ears
• seeing, hearing, or feeling things that are not there
• slow or fast heartbeat
• sweating
• unusual tiredness or weakness

Other side effects of Ongentys

Some side effects of opicapone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• constipation

Less common side effects

• dry mouth
• trouble sleeping
• weight loss

For healthcare professionals

Applies to opicapone: oral capsule.

General adverse events

The most commonly reported adverse reaction was dyskinesia.^[Ref]

Nervous system

• Very common (10% or more): Dyskinesia (17.7%)
• Common (1% to 10%): Dizziness, headache, somnolence
• Uncommon (0.1% to 1%): Dysgeusia, hyperkinesia, syncope
• Postmarketing reports: Balance disorder, hyperkinesia tremor^[Ref]

Psychiatric

• Common (1% to 10%): Abnormal dreams, hallucination, visual hallucination, insomnia
• Uncommon (0.1% to 1%): Anxiety, depression, auditory hallucination, nightmares, sleep disorder
• Postmarketing reports: Agitation, psychotic disorder, confusional state^[Ref]

Cardiovascular

• Common (1% to 10%): Orthostatic hypotension
• Uncommon (0.1% to 1%): Palpitations, hypertension, hypotension^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, dry mouth, vomiting
• Uncommon (0.1% to 1%): Abdominal distention, abdominal pain, upper abdominal pain, dyspepsia
• Postmarketing reports: Diarrhea, nausea^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Decreased appetite, hypertriglyceridemia, decreased weight^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Dyspnea^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Chromaturia, nocturia^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle spasms
• Uncommon (0.1% to 1%): Muscle twitching, musculoskeletal stiffness, myalgia, extremity pain^[Ref]

Ocular

• Uncommon (0.1% to 1%): Dry eye

Other

• Common (1% to 10%): Blood creatine phosphokinase increased
• Uncommon (0.1% to 1%): Ear congestion
• Postmarketing reports: Fatigue, malaise^[Ref]

Frequently asked questions

• When is the best time to take Ongentys?
• How long does it take for Ongentys to work?
• Is Ongentys better than Comtan?

Further information

Ongentys side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer