Norflex Injectable Side Effects

Generic name: orphenadrine

Medically reviewed by Drugs.com. Last updated on Aug 8, 2024.

Note: This document provides detailed information about Norflex Injectable Side Effects associated with orphenadrine. Some dosage forms listed on this page may not apply specifically to the brand name Norflex Injectable.

Applies to orphenadrine: injection solution.

Other dosage forms:

• oral tablet extended release

Serious side effects of Norflex Injectable

Along with its needed effects, orphenadrine (the active ingredient contained in Norflex Injectable) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking orphenadrine:

Rare side effects

• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives
• itching
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• shortness of breath
• skin rash
• tightness in chest
• unusual tiredness or weakness
• wheezing

Incidence not known

• abdominal or stomach pain
• diarrhea
• fast, pounding, or irregular heartbeat or pulse
• fever
• glaucoma
• joint or muscle pain
• nausea
• numbness or tingling of face, hands, or feet
• redness and soreness of eyes
• shortness of breath
• sores in mouth
• swelling of feet or lower legs
• vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking orphenadrine:

Symptoms of Overdose

• blurred vision
• confusion, delirium, or hallucinations
• constipation
• difficult urination
• drowsiness
• dry eyes, mouth, nose, or throat
• eye pain
• flushing or redness of face
• troubled breathing

Other side effects of Norflex Injectable

Some side effects of orphenadrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• anxiety
• deep or fast breathing with dizziness
• headache
• irritability
• itching skin
• mental confusion
• nervousness
• numbness of feet, hands and around mouth
• restlessness
• trembling or shaking of hands or feet shakiness in legs, arms, hands, or feet
• unusually large pupils of eyes
• weakness

For healthcare professionals

Applies to orphenadrine: compounding powder, injectable solution, oral tablet extended release.

General adverse events

The more commonly reported adverse reactions are due to the anticholinergic effects of this drug; dry mouth is usually the first adverse effect to appear.

Hypersensitivity

• Rare (less than 0.1%): Anaphylaxis (with IM injection)
• Frequency not reported: Hypersensitivity reactions

Nervous system

• Frequency not reported: Headache, light-headedness, dizziness, drowsiness, syncope, tremor, sedation, convulsions, coordination difficulties^[Ref]

Psychiatric

• Rare (less than 0.1%): Memory disturbances
• Frequency not reported: Hallucinations, agitation, euphoria, restlessness, mental confusion (especially elderly)^[Ref]

Ocular

• Frequency not reported: Blurred vision, dilatation of pupils, increased ocular tension, accommodation disorders^[Ref]

Cardiovascular

• Frequency not reported: Tachycardia, palpitations^[Ref]

Gastrointestinal

• Frequency not reported: Dry mouth, nausea, vomiting, constipation, gastric irritation^[Ref]

Genitourinary

• Frequency not reported: Urinary hesitancy, urinary retention^[Ref]

Musculoskeletal

• Frequency not reported: Weakness^[Ref]

Dermatologic

• Rare (less than 0.1%): Urticaria, other dermatoses
• Frequency not reported: Pruritus^[Ref]

Hematologic

• Rare (less than 0.1%): Aplastic anemia^[Ref]

Further information

Norflex Injectable side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer