Nexiclon XR Side Effects

Generic name: clonidine

Medically reviewed by Drugs.com. Last updated on Jun 19, 2024.

Note: This document provides detailed information about Nexiclon XR Side Effects associated with clonidine. Some dosage forms listed on this page may not apply specifically to the brand name Nexiclon XR.

Applies to clonidine: epidural solution.

Other dosage forms:

• oral tablet, oral tablet extended release
• transdermal patch extended release

Important warnings This medicine can cause some serious health issues

Epidural route (solution)

The 500-mcg/mL strength product should be diluted prior to use in an appropriate solution.

Epidural clonidine is not recommended for obstetrical, postpartum, or perioperative pain management.

The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients.

However, in a rare obstetrical, postpartum or perioperative patient, potential benefits may outweigh the possible risks.

Serious side effects of Nexiclon XR

Along with its needed effects, clonidine (the active ingredient contained in Nexiclon XR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking clonidine:

More common side effects

• dizziness, light-headedness, or fainting
• slow heartbeat

Less common side effects

• chest pain
• extremely shallow or slow breathing
• fast heartbeat
• fever
• hallucinations (seeing, feeling, or hearing things that are not there)
• mental depression
• sleepiness (excessive)
• vomiting

Other side effects of Nexiclon XR

Some side effects of clonidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• anxiety
• confusion
• dry mouth
• nausea
• sleepiness

Less common side effects

• constipation
• ringing, buzzing, or other unexplained noises in the ears
• sweating, unusual
• weakness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

• agitation
• headache
• nervousness
• pounding heartbeat
• shaking or trembling

For healthcare professionals

Applies to clonidine: compounding powder, injectable solution, oral suspension extended release, oral tablet, oral tablet extended release, transdermal film extended release.

General adverse events

Most adverse effects are mild and diminish with continued therapy. The most frequent (which appear to be dose-related) are dry mouth (40%), drowsiness (33%), dizziness (16%), constipation (10%), and sedation (10%).^[Ref]

Dermatologic

• Very common (10% or more): Contact dermatitis with the patch formulation (19%)
• Common (1% to 10%): Sweating
• Uncommon (0.1% to 1%): Pruritus, rash (localized or generalized), urticaria, erythema
• Rare (0.01% to 0.1%): Alopecia, excoriation, burning
• Very rare (less than 0.01%): Papules, throbbing, blanching, generalized macular rash, facial/tongue angioedema
• Frequency not reported: Hives, localized hypo or hyper pigmentation^[Ref]

Endocrine

• Rare (0.01% to 0.1%): Gynecomastia^[Ref]

Gastrointestinal

• Very common (10% or more): Dry mouth (40%), upper abdominal pain (15%), nausea (13%), vomiting (10%)
• Common (1% to 10%): Constipation, parotid gland pain
• Uncommon (0.1% to 1%): Colonic pseudo-obstruction
• Very rare (less than 0.01%): Parotitis^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction
• Frequency not reported: Micturition difficulty, loss of libido, decreased sexual activity, nocturia, urinary retention^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension (45%), orthostatic hypotension (32%)
• Common (1% to 10%): Chest pain, tachycardia
• Uncommon (0.1% to 1%): Sinus bradycardia, Raynaud's phenomenon, palpitations
• Rare (0.01% to 0.1%): Atrioventricular block, palpitations, bradycardia, syncope, congestive heart failure, electrocardiographic abnormalities (i.e., sinus node arrest, high degree AV block), cerebrovascular accident
• Frequency not reported: Bradyarrhythmia, hypertension, rebound hypertension^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Peripheral blood flow disturbance, thrombocytopenia^[Ref]

Hepatic

• Frequency not reported: Mild transient abnormalities of liver function tests, hepatitis^[Ref]

Metabolic

• Rare (0.01% to 0.1%): Blood glucose increased, serum creatine phosphokinase increased
• Frequency not reported: Weight gain, anorexia^[Ref]

Musculoskeletal

• Frequency not reported: Muscle pain, joint pain, leg cramps^[Ref]

Nervous system

• Very common (10% or more): Drowsiness (33%), dizziness (16%), somnolence (13%), sedation (10%)
• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Paresthesia
• Frequency not reported: Headache, localized numbness^[Ref]

Ocular

• Rare (0.01% to 0.1%): Lacrimation decreased (dry eyes)
• Frequency not reported: Accommodation disorder, ocular burning, vision blurred^[Ref]

Other

• Common (1% to 10%): Fatigue, tinnitus
• Uncommon (0.1% to 1%): Malaise
• Frequency not reported: Fever, pallor, weakness, positive Coombs' test, increased sensitivity to alcohol^[Ref]

Psychiatric

• Very common (10% or more): Confusion (13%)
• Common (1% to 10%): Depression, tearfulness, sleep disorder, hallucinations (both visual and auditory), nervousness, agitation

Uncommon (0.1% to 1%):

• Rare (0.01% to 0.1%): Delusional perception, nightmare
• Frequency not reported: Libido decreased, restlessness, anxiety, irritability, behavior changes^[Ref]

Respiratory

• Common (1% to 10%): Hypoventilation
• Rare (0.01% to 0.1%): Nasal dryness^[Ref]

Further information

Nexiclon XR side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer