Methyltestosterone Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 10, 2024.

Applies to methyltestosterone: oral capsules, oral tablets.

Side effects include:

Males: Gynecomastia, frequent or persistent penile erections.

Females: Amenorrhea, other menstrual irregularities, inhibition of gonadotropin secretion, virilization (e.g., deepening of the voice, clitoral enlargement).

For healthcare professionals

Applies to methyltestosterone: compounding powder, oral capsule, oral tablet.

General adverse events

The more commonly reported adverse effects of androgen therapy in males is gynecomastia and excessive frequency and duration of penile erections; in women, virilization including voice deepening and clitoral enlargement.^[Ref]

Cardiovascular

• Frequency not reported: Edema with or without congestive heart failure, myocardial infarction, stroke
• Postmarketing reports: venous thromboembolic events, including deep vein thrombosis (DVT)^[Ref]

Endocrine

• Frequency not reported: Gynecomastia, virilization (women), hirsutism^[Ref]

Hepatic

• Rare (less than 0.1%): Peliosis hepatic
• Frequency not reported: Cholestatic jaundice, altered liver function^[Ref]

Genitourinary

• Frequency not reported: Amenorrhea, menstrual irregularities, excessive frequency and duration of penile erections, oligospermia, increased or decreased libido^[Ref]

Metabolic

• Frequency not reported: Retention of sodium, chloride, water, potassium, calcium and inorganic phosphates, increased serum cholesterol, hypercalcemia^[Ref]

Dermatologic

• Frequency not reported: Male pattern baldness, acne^[Ref]

Gastrointestinal

• Frequency not reported: Nausea, vomiting^[Ref]

Musculoskeletal

• Frequency not reported: acceleration of bone maturation without producing compensatory gain in linear growth resulting in compromised adult stature^[Ref]

Hematologic

• Frequency not reported: Suppression of clotting factors II, V, VII, and X; bleeding (in patients on concomitant anticoagulant therapy and polycythemia)^[Ref]

Hypersensitivity

• Very rare (less than 0.01%): Anaphylactoid reactions^[Ref]

Nervous system

• Frequency not reported: Headache, generalized paresthesia^[Ref]

Oncologic

• Rare (less than 0.1%): Hepatocellular neoplasms^[Ref]

Respiratory

• Postmarketing reports: venous thromboembolic events, including pulmonary embolism^[Ref]

Psychiatric

• Frequency not reported: Steroid abuse, anxiety, depression

Further information

Methyltestosterone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer