Marezine Side Effects

Generic name: cyclizine

Note: This document provides detailed information about Marezine Side Effects associated with cyclizine. Some dosage forms listed on this page may not apply specifically to the brand name Marezine.

Applies to cyclizine: oral tablet, oral tablet chewable.

Important warnings This medicine can cause some serious health issues

Follow all directions on your medicine label and package.

Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Get emergency medical help if you have any of these signs of an allergic reaction while taking cyclizine (the active ingredient contained in Marezine) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using cyclizine and call your doctor at once if you have:

• painful or difficult urination;

• little or no urinating;

• pounding heartbeats or fluttering in your chest; or

• a light-headed feeling, like you might pass out.

Common side effects may include:

• drowsiness, weakness, loss of coordination;

• nausea, dry mouth, constipation; or

• blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to cyclizine: oral tablet, oral tablet chewable.

Nervous system adverse events

• Rare (0.01% to 0.1%): Depressed levels of consciousness, loss of consciousness
• Frequency not reported: Convulsions, coordination abnormal, decreased consciousness, dizziness, drowsiness, dyskinesia, dystonia, extrapyramidal motor disturbances, generalized chorea, headaches, incoordination, paralysis, paresthesia, somnolence, transient speech disorders, tremor^[Ref]

Paralysis was reported with IV formulations and typically affected the limbs within minutes of administration. This side effect usually resolved within hours following discontinuation of treatment.^[Ref]

Other

• Rare (0.01% to 0.1%): Chills, sensation of heaviness
• Frequency not reported: Asthenia, pain, tinnitus^[Ref]

Dermatologic

• Rare (0.01% to 0.1%): Pruritus
• Frequency not reported: Allergic skin reaction, blisters, drug rash, erythema, fixed drug eruption, photosensitivity reaction, urticaria^[Ref]

Gastrointestinal

• Frequency not reported: Abdominal pain upper, constipation, diarrhea, dry mouth, duodenogastric reflux, increased gastric reflux, nausea, stomach pain, vomiting^[Ref]

Psychiatric

• Frequency not reported: Agitation, auditory and visual hallucinations, disorientation, euphoria, insomnia, nervousness, Restlessness^[Ref]

Auditory and visual hallucinations were reported, especially at doses exceeding recommendations.^[Ref]

Cardiovascular

• Frequency not reported: Arrhythmias, hypertension, hypotension, palpitations, tachycardia, thrombophlebitis, vein tracking^[Ref]

Respiratory

• Frequency not reported: Apnea, bronchospasm, dry nose, dry throat^[Ref]

Hepatic

• Frequency not reported: Cholestatic hepatitis, cholestatic jaundice, hypersensitivity hepatitis, liver dysfunction^[Ref]

Hematologic

• Frequency not reported: Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia^[Ref]

Local

• Frequency not reported: Injection site erythema, injection site pain, injection site reactions^[Ref]

Injection site reactions included blisters, erythema, pain, thrombophlebitis, and vein tracking.^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylaxis, angioedema, hypersensitivity reactions^[Ref]

Anaphylaxis occurred with concomitant propanidid given via IV administration in the same syringe.^[Ref]

Metabolic

• Frequency not reported: Decreased appetite, loss of appetite^[Ref]

Musculoskeletal

• Frequency not reported: Muscle spasms, twitching^[Ref]

Ocular

• Frequency not reported: Blurred vision, oculogyric crisis^[Ref]

Genitourinary

• Frequency not reported: Urinary retention^[Ref]

Further information

Marezine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer