Lypqozet Side Effects

Generic name: atorvastatin / ezetimibe

Medically reviewed by Drugs.com. Last updated on May 17, 2024.

Note: This document provides detailed information about Lypqozet Side Effects associated with atorvastatin / ezetimibe. Some dosage forms listed on this page may not apply specifically to the brand name Lypqozet.

Applies to atorvastatin / ezetimibe: oral tablet.

Important warnings This medicine can cause some serious health issues

You should not use this medicine if you have active liver disease or abnormal liver function tests.

Do not use atorvastatin and ezetimibe if you are pregnant or if you could become pregnant. Use effective birth control.

Do not breast-feed while using this medicine.

Get emergency medical help if you have any of these signs of an allergic reaction while taking atorvastatin / ezetimibe: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Stop using this medicine and call your doctor at once if you have:

• nausea, upper stomach pain, loss of appetite;

• itching, unusual tiredness; or

• dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• mild muscle pain;

• stomach pain, diarrhea; or

• joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to atorvastatin / ezetimibe: oral tablet.

General adverse events

The more commonly reported adverse reactions have included increased ALT, increased AST, and musculoskeletal pain.^[Ref]

Hepatic

• Common (1% to 10%): ALT increased (5%), AST increased (4%)
• Postmarketing reports: Hepatitis, cholelithiasis, cholecystitis, fatal and nonfatal hepatic failure^[Ref]

Musculoskeletal

• Common (1% to 10%): Musculoskeletal pain (3.8 to 4%), arthralgia (3 to 6.9%), pain in extremity (2.7 to 6%), myalgia (3.5%), muscle spasms (3%), muscle weakness (2%)
• Postmarketing reports: Myopathy/rhabdomyolysis, necrotizing myopathy (rarely), injury, poisoning and procedural complication, tendon rupture, myositis^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea (4.1 to 6.8%), abdominal pain (3%), nausea (3 to 4%), dyspepsia (4.7%)^[Ref]

Nervous system

• Common (1% to 10%): Dizziness (2 to 6%), insomnia (3%), fatigue (2.4%)
• Postmarketing reports: Headache, paraesthesia, peripheral neuropathy, amnesia, memory impairment, confusion, depression, dizziness^[Ref]

Metabolic

• Common (1% to 10%): Hyperkalemia (2%)^[Ref]

Endocrine

• Common (1% to 10%): Hot flushes (2%)^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection (5.7%)^[Ref]

Hematologic

• Postmarketing reports: Thrombocytopenia, elevated creatine phosphokinase^[Ref]

Hypersensitivity

• Postmarketing reports: Anaphylaxis, hypersensitivity reactions^[Ref]

Immunologic

• Common (1% to 10%): Influenza (2%)^[Ref]

Respiratory

• Common (1% to 10%): Coughing (2 to 3%), bronchitis (2%), sinusitis (2 to 2.8%), upper respiratory tract infection (4.3%), nasopharyngitis (up to 8.3%), pharyngolaryngeal pain (up to 2.3%)
• Postmarketing reports: Interstitial lung disease^[Ref]

Other

• Postmarketing reports: Fatigue

Dermatologic

• Postmarketing reports: Angioedema, bullous rashes (including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), rash, urticaria^[Ref]

Further information

Lypqozet side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer