Lymphocyte Immune Globulin, Anti-thy (equine) Side Effects

Medically reviewed by Drugs.com. Last updated on May 10, 2024.

Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.

Important warnings This medicine can cause some serious health issues

• Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.^b

• Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.^b

Side effects include:

Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).

Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.

For healthcare professionals

Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.

Hypersensitivity adverse events

• Uncommon (0.1% to 1%): Anaphylactic reaction^[Ref]

Dermatologic

• Very common (10% or more): Rash (26%)
• Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper
• Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)
• Postmarketing reports: Hyperhidrosis^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (17%)
• Common (1% to 10%): Chest pain, back pain^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea
• Uncommon (0.1% to 1%): Stomatitis
• Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain^[Ref]

Cardiovascular

• Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion
• Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)
• Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea
• Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema
• Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia
• Postmarketing reports: Dyskinesia, Syncope, tremor^[Ref]

Local

• Common (1% to 10%): Infusion site pain
• Postmarketing reports: Infusion site erythema, infusion site swelling^[Ref]

Renal

• Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis
• Postmarketing reports: Kidney rupture, renal failure acute^[Ref]

Ocular

• Uncommon (0.1% to 1%): Periorbital edema^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria
• Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity^[Ref]

Hepatic

• Common (1% to 10%): Liver function test abnormal^[Ref]

Immunologic

• Common (1% to 10%): Infection
• Uncommon (0.1% to 1%): Serum sickness
• Postmarketing reports: Hepatitis viral, localized infection, systemic infection^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Agitation
• Postmarketing reports: Confusion, disorientation^[Ref]

Other

• Very common (10% or more): Pyrexia (40%), chills (27%)
• Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence
• Postmarketing reports: Aplasia, pain^[Ref]

Further information

Lymphocyte immune globulin, anti-thy (equine) side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer