Lutathera Side Effects

Generic name: lutetium lu 177 dotatate

Medically reviewed by Drugs.com. Last updated on Jul 16, 2024.

Note: This document provides detailed information about Lutathera Side Effects associated with lutetium lu 177 dotatate. Some dosage forms listed on this page may not apply specifically to the brand name Lutathera.

Applies to lutetium lu 177 dotatate: intravenous solution.

Serious side effects of Lutathera

Along with its needed effects, lutetium lu 177 dotatate (the active ingredient contained in Lutathera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lutetium lu 177 dotatate:

More common side effects

• agitation
• anxiety
• black, tarry stools
• bleeding gums
• blood in the urine or stools
• blurred vision
• chills
• cold sweats
• confusion
• cool, pale skin
• cough
• decreased urine output
• diarrhea
• difficulty in breathing
• dizziness
• dry mouth
• feeling of warmth
• fever
• flushed, dry skin
• fruit-like breath odor
• headache
• hoarseness
• hostility
• increased hunger
• increased thirst
• increased urination
• irritability
• joint pain, stiffness, or swelling
• loss of appetite
• loss of consciousness
• lower back, side, arm, leg, or stomach pain
• mood changes
• mood or mental changes
• muscle cramps in the hands, arms, feet, legs, or face
• muscle pain or twitching
• nausea
• nervousness
• nightmares
• numbness and tingling around the mouth, lips, hands, fingertips, or feet
• painful or difficult urination
• pale skin
• pinpoint red spots on the skin
• pounding in the ears
• rapid weight gain
• redness of the face, neck, arms, and occasionally, upper chest
• restlessness
• seizures
• shakiness
• slow, fast, or irregular heartbeat
• slurred speech
• sore throat
• sweating
• swelling of the face, feet, lower legs, ankles, or hands
• tremor
• troubled breathing
• troubled breathing with exertion
• ulcers, sores, or white spots in the mouth
• unexplained weight loss
• unusual bleeding or bruising
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• vomiting
• weakness or heaviness of the legs

Less common side effects

• bone pain
• chest pain or discomfort
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• extreme tiredness or weakness
• irregular breathing
• pain or discomfort in the arms, jaw, back, or neck
• swollen glands

Other side effects of Lutathera

Some side effects of lutetium lu 177 dotatate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• constipation
• decreased appetite
• hair loss or thinning of the hair
• loss or change in taste

Less common side effects

• difficulty in moving
• neck pain

For healthcare professionals

Applies to lutetium lu 177 dotatate: intravenous solution.

Hematologic adverse events

• Common (1% to 10%): Lymphopenia, leukopenia, neutropenia, thrombocytopenia, anemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, pain in extremity, myalgia, neck pain^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite, hyperglycemia, hypocalcemia, hypokalemia, hyperkalemia, hypernatremia, hypoglycemia^[Ref]

Psychiatric

• Common (1% to 10%): Anxiety^[Ref]

Hepatic

• Common (1% to 10%): GGT increased, alkaline phosphatase increased, AST increased, ALT increased, blood bilirubin increased^[Ref]

Respiratory

• Common (1% to 10%): Cough^[Ref]

Other

• Common (1% to 10%): Fatigue, peripheral edema, pyrexia^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, dysgeusia^[Ref]

Renal

• Common (1% to 10%): Renal failure (glomerular filtration rate decreased, acute kidney injury, acute prerenal failure, azotemia, renal disorder, renal failure, renal impairment); hyperuricemia; creatinine increased^[Ref]

Cardiovascular

• Common (1% to 10%): Atrial fibrillation, flushing, hypertension^[Ref]

Dermatologic

• Common (1% to 10%): Alopecia

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting abdominal pain, diarrhea, constipation^[Ref]

Genitourinary

• Common (1% to 10%): Radiation related urinary tract toxicity (dysuria, micturition urgency, nocturia, pollakiuria, renal colic, renal pain, urinary tract pain and urinary incontinence)

Frequently asked questions

• How does Lutathera work to treat gastroenteropancreatic neuroendocrine tumors?

Further information

Lutathera side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer