Luspatercept Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 10, 2025.

Applies to luspatercept: parenteral injection for sub-q use.

Side effects include:

Most common (>10%) adverse reactions: fatigue, headache, musculoskeletal pain, arthralgia, dizziness/vertigo, nausea, diarrhea, cough, abdominal pain, dyspnea, COVID-19, peripheral edema, hypertension, hypersensitivity.

For healthcare professionals

Applies to luspatercept: subcutaneous powder for injection.

Hepatic adverse events

• Very common (10% or more): Total bilirubin 2 or more times the upper limit of normal (ULN) (64%), alanine aminotransferase 3 or more times ULN (12%), aspartate aminotransferase 3 or more times ULN (11%)
• Common (1% to 10%): Alkaline phosphatase 2 or more times ULN, direct bilirubin 2 or more times ULN^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension, deep vein thrombosis^[Ref]

Nervous system

• Very common (10% or more): Headache (26%), dizziness (11%)
• Common (1% to 10%): Cerebrovascular accident^[Ref]

Musculoskeletal

• Very common (10% or more): Bone pain (20%), arthralgia (19%)^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (14%), diarrhea (12%)
• Common (1% to 10%): Nausea^[Ref]

Metabolic

• Common (1% to 10%): Hyperuricemia^[Ref]

Respiratory

• Very common (10% or more): Cough (14%)^[Ref]

Immunologic

• Common (1% to 10%): Influenza, viral upper respiratory infection^[Ref]

Other

• Very common (10% or more): Fatigue (14%)
• Frequency not reported: Death (due to unconfirmed acute myelogenous leukemia)^[Ref]

Further information

Luspatercept side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer