Luspatercept Side Effects

Medically reviewed by Drugs.com. Last updated on May 10, 2024.

Applies to luspatercept: parenteral injection for sub-q use.

Side effects include:

Most common (>10%) adverse reactions: fatigue, headache, musculoskeletal pain, arthralgia, dizziness/vertigo, nausea, diarrhea, cough, abdominal pain, dyspnea, COVID-19, peripheral edema, hypertension, hypersensitivity.

For Healthcare Professionals

Applies to luspatercept: subcutaneous powder for injection.

Hepatic

Very common (10% or more): Total bilirubin 2 or more times the upper limit of normal (ULN) (64%), alanine aminotransferase 3 or more times ULN (12%), aspartate aminotransferase 3 or more times ULN (11%)

Common (1% to 10%): Alkaline phosphatase 2 or more times ULN, direct bilirubin 2 or more times ULN^[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, deep vein thrombosis^[Ref]

Nervous system

Very common (10% or more): Headache (26%), dizziness (11%)

Common (1% to 10%): Cerebrovascular accident^[Ref]

Musculoskeletal

Very common (10% or more): Bone pain (20%), arthralgia (19%)^[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain (14%), diarrhea (12%)

Common (1% to 10%): Nausea^[Ref]

Metabolic

Common (1% to 10%): Hyperuricemia^[Ref]

Respiratory

Very common (10% or more): Cough (14%)^[Ref]

Immunologic

Common (1% to 10%): Influenza, viral upper respiratory infection^[Ref]

Other

Very common (10% or more): Fatigue (14%)

Frequency not reported: Death (due to unconfirmed acute myelogenous leukemia)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer