Hydrogen Peroxide Topical Side Effects

Medically reviewed by Drugs.com. Last updated on May 11, 2024.

Applies to hydrogen peroxide topical: topical application gel/jelly, topical application pad, topical application solution, topical application spray.

Serious side effects

Along with its needed effects, hydrogen peroxide topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hydrogen peroxide topical:

More common side effects

• redness, blistering, peeling, or loosening of the skin
• skin burning, itching, pain, rash, stinging, or swelling skin ulcers

Less common side effects

• cracking or scarring of the skin
• thinning, weakness, or wasting away of the skin

Rare side effects

• eyelid swelling
• painful blisters on the trunk of the body

Other side effects

Some side effects of hydrogen peroxide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• darkening of the skin
• dryness, peeling, or crusting of the skin
• lightening of normal skin color
• lightening of the treated areas of dark skin

Further information

Hydrogen peroxide topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer