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Hiprex Side Effects

Generic name: methenamine

Medically reviewed by Drugs.com. Last updated on May 11, 2024.

Note: This document provides detailed information about Hiprex Side Effects associated with methenamine. Some dosage forms listed on this page may not apply specifically to the brand name Hiprex.

Applies to methenamine: oral tablet.

Serious side effects of Hiprex

Along with its needed effects, methenamine (the active ingredient contained in Hiprex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methenamine:

Less common side effects

Rare side effects

  • blood in urine
  • lower back pain
  • pain or burning while urinating

Other side effects of Hiprex

Some side effects of methenamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

Managing side effects (general information)

For healthcare professionals

Applies to methenamine: compounding powder, oral suspension, oral tablet.

General adverse events

This drug was generally well tolerated. Minor side effects have been reported in less than 3.5% of patients and were reversible when the drug was stopped.[Ref]

Dermatologic

Gastrointestinal

Genitourinary

High doses have been associated with albuminuria, gross hematuria, bladder irritation, and painful/frequent micturition.[Ref]

Hepatic

Hypersensitivity

Metabolic

Ocular

References

1. (2002) "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

4. Brumfitt W, Hamilton-Miller J, Gargan R, Cooper J, Smith GW (1983) "Long-term prophylaxis of urinary infections in women: comparative trial of trimethoprim, methenamine hippurate and topical povidone-iodine." J Urol, 130, p. 1110-4

5. Gleckman R, Alvarez S, Joubert D, Matthews S (1979) "Drug therapy reviews: methenamine mandelate and methenamine hippurate." Am J Hosp Pharm, 36, p. 1509-12

6. Australian Drug Evaluation Committee (1972) "Adverse effects of drugs commonly used in the treatment of urinary tract infection." Med J Aust, 1, p. 435-8

7. (2002) "Product Information. Mandelamine (methenamine)." Parke-Davis

8. Brumfitt W, Cooper J, Hamilton-Miller J (1981) "Prevention of recurrent urinary infections in women: a comparative trial between nitrofurantoin and methenamine hippurate." J Urol, 126, p. 71-4

9. Kolker RJ (1991) "Medication-induced bilateral anterior uveitis." Arch Ophthalmol, 109, p. 1343

Further information

Hiprex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer