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Hemabate Side Effects

Generic name: carboprost

Medically reviewed by Drugs.com. Last updated on Mar 14, 2024.

Note: This document provides detailed information about Hemabate Side Effects associated with carboprost. Some dosage forms listed on this page may not apply specifically to the brand name Hemabate.

Applies to carboprost: intramuscular solution.

Important warnings This medicine can cause some serious health issues

Intramuscular route (solution)

Carboprost tromethamine, like other potent oxytocic agents, should be used only with strict adherence to recommended dosages.

Carboprost tromethamine should be used by medically trained personnel in a hospital which can provide immediate intensive care and acute surgical facilities.

Common side effects of Hemabate

Some side effects of carboprost may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

Less common or rare side effects

  • chills or shivering
  • dizziness
  • fever (temporary)
  • flushing or redness of face
  • headache
  • stomach cramps or pain

This procedure may result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if you notice any of the following:

Serious side effects of Hemabate

Along with its needed effects, carboprost (the active ingredient contained in Hemabate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking carboprost:

Less common or rare side effects

  • fast or slow heartbeat
  • headache (severe and continuing)
  • hives or skin rash
  • increased pain of the uterus
  • pale, cool, blotchy skin on arms or legs
  • pressing or painful feeling in chest
  • shortness of breath
  • swelling of face, inside the nose, and eyelids
  • tightness in chest
  • trouble in breathing
  • weak or absent pulse in arms or legs
  • wheezing

Check with your doctor as soon as possible if any of the following side effects occur while taking carboprost:

For healthcare professionals

Applies to carboprost: injectable solution.

General adverse events

Transient pyrexia may be due to the effect of carboprost (the active ingredient contained in Hemabate) on hypothalamic thermoregulation. Temperature elevation exceeding 2 degrees Fahrenheit have been reported in approximately 12.5% of the patients who received the recommended dosage regimen. In all cases, temperature returned to normal when therapy ended.[Ref]

Contractile effect on smooth muscle, nausea, vomiting, diarrhea, increased temperature and flushing are the most frequent adverse reactions observed.

Adverse effects of this drug are generally transient and reversible when therapy ends.

Endometritis, retained placental fragments, and excessive uterine bleeding were the most common complications after discharge from the hospital.[Ref]

Gastrointestinal

Pretreatment or concurrent administration of antiemetic and antidiarrheal drugs considerably decreases the very high incidence of gastrointestinal side effects that are common with all prostaglandins used for abortion.[Ref]

Other

Cardiovascular

The degree of hypertension was moderate and it is not certain as to whether it was due to a direct effect of carboprost or a return to a status of pregnancy associated hypertension manifested by the correction of hypovolemic shock.[Ref]

Genitourinary

When carboprost was used for abortion, the most common complications which required additional treatment after discharge from the hospital were endometritis, retained placental fragments, and excessive uterine bleeding which was reported to have occurred in approximately 2% of patients.[Ref]

Nervous system

Respiratory

Dermatologic

Local

Musculoskeletal

Ocular

Psychiatric

Endocrine

Hypersensitivity

References

1. Bigby M (2000) "A systematic review of the treatment of scabies." Arch Dermatol, 136, p. 387-9

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Hemabate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.