Gentamicin / Prednisolone Ophthalmic Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 22, 2024.

Applies to gentamicin/prednisolone ophthalmic: ophthalmic suspension.

Important warnings This medicine can cause some serious health issues

You should not use this medicine if you have a fungal or viral infection in your eyes (including herpes simplex).

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious side effects are unlikely when gentamicin and prednisolone is used in the eyes, but can occur if the medicine is absorbed into your bloodstream.

Call your doctor at once if you have:

• eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);

• eye pain, tearing, sensitivity to light;

• blurred vision, tunnel vision, seeing halos around lights; or

• a wound that will not heal.

Stop using this medicine and talk to your doctor if you have new or worsening eye pain or swelling that lasts longer than 48 hours.

Common side effects may include:

• burning, stinging, redness, or other irritation of the eyes;

• blurred vision;

• feeling like something is in your eye; or

• unusual or unpleasant taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to gentamicin / prednisolone ophthalmic: ophthalmic ointment, ophthalmic suspension.

General adverse events

The most frequently reported side effects were ocular discomfort, irritation following instillation, and punctate keratitis.^[Ref]

Ocular

• Frequency not reported: Superficial punctate keratitis, ocular discomfort

Prednisolone:

• Frequency not reported: Intraocular pressure increased, glaucoma, optic nerve damage, posterior subcapsular cataract formation^[Ref]

Local

• Frequency not reported: Burning, stinging, irritation^[Ref]

Other

• Frequency not reported: Secondary ocular infection developed

Prednisolone:

• Frequency not reported: Wound healing delayed^[Ref]

Immunologic

Gentamicin:

• Frequency not reported: Allergic sensitization^[Ref]

Further information

Gentamicin/prednisolone ophthalmic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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