Elacestrant Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 20, 2024.

Applies to elacestrant: oral tablet.

Common side effects of elacestrant

Some side effects of elacestrant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• belching
• constipation
• decreased appetite
• diarrhea
• headache
• heartburn
• hot flush
• indigestion
• muscle or bone pain
• nausea
• stomach discomfort, upset, or pain
• unusual tiredness or weakness
• vomiting

Serious side effects of elacestrant

Along with its needed effects, elacestrant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

For healthcare professionals

Applies to elacestrant: oral tablet.

General adverse events

Very common adverse reactions (>10%) included musculoskeletal pain, nausea, increased cholesterol, increased AST, increased triglycerides, fatigue, decreased hemoglobin, vomiting, increased ALT, decreased sodium, increased creatinine, decreased appetite, diarrhea, headache, constipation, abdominal pain, hot flush, and dyspepsia.^[Ref]

Cardiovascular

• Very common (10% or more): Hot flushes (11%)
• Frequency not reported: Cardiac arrest, septic shock^[Ref]

Dermatologic

• Frequency not reported: Rash^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (35%), vomiting (19%), diarrhea (13%), constipation (12%), abdominal pain (11%), dyspepsia (10%)
• Frequency not reported: Diverticulitis, stomatitis, gastroesophageal reflux disease^[Ref]

Hematologic

• Very common (10% or more): Decreased hemoglobin (26%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (41%)^[Ref]

Metabolic

• Very common (10% or more): Increased cholesterol (30%), increased triglycerides (27%), hyponatremia (16%), decreased appetite (15%)^[Ref]

Psychiatric

• Frequency not reported: Insomnia^[Ref]

Hepatic

• Very common (10% or more): Increased aspartate aminotransferase (29%), increased alanine aminotransferase (17%)^[Ref]

Respiratory

• Frequency not reported: Dyspnea, cough^[Ref]

Other

• Very common (10% or more): Fatigue (26%)^[Ref]

Nervous system

• Very common (10% or more): Headache (12%)
• Frequency not reported: Dizziness^[Ref]

Renal

• Very common (10% or more): Increased creatinine (16%)^[Ref]

Further information

Elacestrant side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer