Despec-PD Side Effects

Generic name: chlorpheniramine / dihydrocodeine / phenylephrine

Note: This document provides detailed information about Despec-PD Side Effects associated with chlorpheniramine / dihydrocodeine / phenylephrine. Some dosage forms listed on this page may not apply specifically to the brand name Despec-PD.

Applies to chlorpheniramine/dihydrocodeine/phenylephrine: oral liquid, oral syrup.

Important warnings This medicine can cause some serious health issues

You should not use this medicine if you have bladder obstruction or urination problems, uncontrolled high blood pressure, severe coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or uncontrolled asthma.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days.

A dangerous drug interaction could occur.

MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• pounding heartbeats or fluttering in your chest;

• a light-headed feeling, like you might pass out;

• severe anxiety, confusion, fear;

• painful or difficult urination;

• little or no urinating; or

• dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common side effects may include:

• dizziness, drowsiness, mood changes;

• feeling excited or irritable;

• problems with thinking or memory;

• flushing (warmth, redness, or tingly feeling);

• blurred vision; or

• nausea, dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to chlorpheniramine / dihydrocodeine / phenylephrine: oral liquid, oral syrup.

General adverse events

General side effects including light-headedness, dizziness, drowsiness, headache, fatigue, and sedation have been among the most frequently reported with opioid use. Confusion, abdominal pain, lassitude, giddiness, increased irritability or excitement (especially in children) have been reported. Hallucinations, severe narcosis, and vivid dreams have been reported rarely.^[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and constipation have been among the most frequently reported with opioid use. Diarrhea, dry mouth, indigestion, anorexia, spasm of biliary tract have been reported.^[Ref]

Dermatologic

Dermatologic side effects including sweating, pruritus, and skin reactions have been among the most frequently reported with opioid use. Flushing has been reported.^[Ref]

Other

Other side effects of dihydrocodeine have included psychological dependence, physical dependence, and tolerance have been reported to develop upon repeated administration.^[Ref]

Symptoms of dihydrocodeine withdrawal consist of irritability, restlessness, insomnia, diaphoresis, anxiety, and palpitations.^[Ref]

Renal

Renal side effects including granulomatous interstitial nephritis and acute renal failure have been reported rarely during dihydrocodeine administration.^[Ref]

Cardiovascular

Cardiovascular side effects including orthostatic hypotension and cardiac palpitations have been reported.^[Ref]

Respiratory

Respiratory side effects including respiratory depression have been reported.^[Ref]

Ocular

Ocular side effects including miosis and blurred vision have been reported.^[Ref]

Genitourinary

Genitourinary side effects including urinary retention have been reported.^[Ref]

Hypersensitivity

Hypersensitivity side effects including anaphylactoid reactions have been reported rarely.^[Ref]

Further information

Despec-PD side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer