Daunorubicin Liposomal Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 3, 2024.

Applies to daunorubicin liposomal: intravenous dispersion.

Important warnings This medicine can cause some serious health issues

Daunorubicin liposomal may cause dangerous effects on your heart. Call your doctor at once if you have chest pain, shortness of breath (even with mild exertion), swelling, or rapid weight gain.

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, or have back pain and chest tightness.

Daunorubicin liposomal can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, or have back pain and chest tightness.

Call your doctor at once if you have:

• chest pain, shortness of breath (even with mild exertion), swelling, rapid weight gain;

• fever, chills, body aches, flu symptoms, sores in your mouth and throat;

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);

• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• pain, burning, irritation, or skin changes where the injection was given.

Common side effects may include:

• mild nausea, vomiting, diarrhea, stomach pain;

• cough;

• headache;

• temporary hair loss, mild itching or rash; or

• red colored urine for 1 or 2 days following a dose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to daunorubicin liposomal: intravenous dispersion.

Hematologic adverse events

• Very common (10% or more): Bone marrow suppression, bone marrow failure, agranulocytosis, neutropenia, febrile neutropenia, leucopenia, pancytopenia, thrombocytopenia, anemia, hemorrhage^[Ref]

Cardiovascular

• Common (1% to 10%): Decreased left ventricular ejection fraction
• Uncommon (0.1% to 1%): Congestive heart failure, cardiomyopathy
• Rare (less than 0.1%): Atrial fibrillation, myocardial infarction
• Frequency not reported: Shock^[Ref]

Dermatologic

• Very common (10% or more): Alopecia
• Rare (less than 0.1%): Palmar-plantar erythrodysesthesia syndrome^[Ref]

Gastrointestinal

• Very common (10% or more): Stomatitis, mucous ulcerations, nausea, vomiting, diarrhea, abdominal pain^[Ref]

Local

• Very common (10% or more): Infusion-associated reactions (e.g., back pain, flushing, chest tightness, dyspnea, allergic reaction), extravasation at the injection site (erythema, pain, swelling)^[Ref]

Hepatic

• Frequency not reported: Transient elevations in serum bilirubin, transient elevations in aspartate aminotransferase (AST), transient elevations in alkaline phosphatase (ALP), hepatitis, hepatic failure^[Ref]

Other

• Very common (10% or more): Asthenia, fatigue, fever, chills^[Ref]

Immunologic

• Very common (10% or more): infections
• Uncommon (0.1% to 1%): Sepsis, septic shock^[Ref]

Metabolic

• Common (1% to 10%): Dehydration^[Ref]

Genitourinary

• Frequency not reported: Red discoloration of urine, amenorrhea, azoospermia^[Ref]

Hypersensitivity

• Very common (10% or more): Allergic reaction
• Rare (less than 0.1%): Anaphylactic reaction^[Ref]

Psychiatric

• Common (1% to 10%): Depression^[Ref]

Further information

Daunorubicin liposomal side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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