Dasatinib Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 28, 2023.
Applies to dasatinib: oral tablet.
Serious side effects of Dasatinib
Along with its needed effects, dasatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dasatinib:
More common
- Bleeding gums
- bloody or black, tarry stools
- body aches or pain
- burning, tingling, numbness, or pain in the hands, arms, feet, or legs
- chest pain or tightness
- chills
- constipation
- cough
- coughing up blood
- decrease in the amount of urine
- dizziness
- ear congestion
- fainting
- fast, slow, or irregular heartbeat
- fever
- full or bloated feeling
- headache
- hoarseness
- increased menstrual flow or vaginal bleeding
- loss of voice
- lower back or side pain
- noisy or rattling breathing
- nosebleeds
- painful or difficult urination
- pale skin
- paralysis
- pressure in the stomach
- prolonged bleeding from cuts
- red or dark brown urine
- runny or stuffy nose
- sensation of pins and needles
- severe stomach pain
- sneezing
- sore throat
- stabbing pain
- swelling of the stomach area
- swelling of the face, fingers, hands, feet, or lower legs
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- weakness in the arms, hands, legs, or feet
- weight gain
Less common
- Blue lips and fingernails
- chest discomfort
- coughing that sometimes produces a pink frothy sputum
- difficult or fast breathing
- dilated neck veins
- increased sweating
- irregular breathing
- loss of appetite
- nausea
- stomach pain, severe
- swelling in the legs and ankles
- vomiting
- yellow eyes or skin
Incidence not known
- Anxiety
- blistering, peeling, or loosening of the skin
- blurred vision
- cloudy or bloody urine
- diarrhea
- itching
- joint or muscle pain
- nervousness
- pain, redness, or swelling in the arm or leg
- pounding in the ears
- red skin lesions, often with a purple center
- red, irritated eyes
- sudden weakness in the arms or legs
- sudden, severe chest pain
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
Other side effects of Dasatinib
Some side effects of dasatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bone pain
- cracked lips
- difficulty with moving
- difficulty with swallowing
- lack or loss of strength
- loss of appetite
- muscle aching, cramping, or stiffness
- pain
- skin rash
- stomach pain
- swollen joints
- vomiting
- weight loss
For Healthcare Professionals
Applies to dasatinib: oral tablet.
Hematologic
In the phase III dose optimization study in patients with chronic phase CML, grade 3 or 4 myelosuppression occurred more frequently in patients treated with the 70 mg twice daily regimen than in those treated with a 100 mg once daily regimen.[Ref]
Very common (10% or more): Hemorrhage (11 to 26%)
Common (1% to 10%): Febrile neutropenia, pancytopenia
Uncommon (0.1% to 1%): CNS bleeding
Rare (Less than 0.1%): Aplasia pure red cell[Ref]
General
The most common side effects included fluid retention, musculoskeletal pain, diarrhea, rash, and headache.[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (18 to 31%), vomiting (11 to 16%), nausea (18 to 24%), abdominal pain (12%)
Common (1% to 10%): Enterocolitis infection, gastrointestinal bleeding, neutropenic colitis, gastritis, mucositis, stomatitis, dyspepsia, abdominal distension, constipation, oral soft tissue disorder
Uncommon (0.1% to 1%): Pancreatitis, upper gastrointestinal ulcer, esophagitis, ascites, anal fissure, dysphagia
Rare (Less than 0.1%): Protein-losing gastroenteropathy, ileus
Postmarketing reports: Fatal gastrointestinal hemorrhage[Ref]
Nervous system
Very common (10% or more): Headache (13 to 33%)
Common (1% to 10%): Neuropathy, peripheral neuropathy, dizziness, dysgeusia, somnolence
Uncommon (0.1% to 1%): Syncope, amnesia, tremor
Rare (Less than 0.1%): Cerebrovascular accident, transient ischemic attack, convulsion, optic neuritis, seventh nerve paralysis[Ref]
Musculoskeletal
Very common (10% or more): Musculoskeletal pain (11 to 22%)
Common (1% to 10%): Arthralgia, myalgia, muscular weakness, musculoskeletal stiffness, muscle spasm, chills
Uncommon (0.1% to 1%): Rhabdomyolysis, muscle inflammation, tendonitis, blood creatine phosphokinase increased[Ref]
Respiratory
Very common (10% or more): Pleural effusion (11 to 24%), dyspnea (15 to 24%), cough
Common (1% to 10%): Pneumonia (including bacterial, viral, fungal), upper respiratory tract infection, pulmonary edema, pulmonary hypertension, lung infiltration, pneumonitis
Uncommon (0.1% to 1%): Bronchospasm, asthma
Rare (Less than 0.1%): Acute respiratory distress syndrome
Postmarketing reports: Pulmonary embolism, interstitial lung disease, pulmonary arterial hypertension[Ref]
Metabolic
Common (1% to 10%): Anorexia, appetite disturbances, hyperuricemia, weight decreased, weight increased
Uncommon (0.1% to 1%): Hypoalbuminemia[Ref]
Hepatic
Uncommon (0.1% to 1%): Hepatitis, cholecystitis, cholestasis[Ref]
Cardiovascular
Common (1% to 10%): Congestive heart failure, cardiac dysfunction, pericardial effusion, arrhythmia, tachycardia, palpitations, hypertension, chest pain
Uncommon (0.1% to 1%): Myocardial infarction, electrocardiogram QT prolongation, pericarditis, ventricular arrhythmia, ventricular tachycardia, angina pectoris, cardiomegaly, hypotension
Rare (less than 0.1%): Cor pulmonale, myocarditis, acute coronary syndrome
Postmarketing reports: Atrial fibrillation, atrial flutter[Ref]
Results from phase II single arm clinical studies of 911 patients reported QT prolongation in 9 patients. Three patients (less than 1%) experienced a QTcF greater than 500 milliseconds.
In the phase III dose optimization study in patients with chronic phase CML, pleural effusion and congestive cardiac failure/cardiac dysfunction occurred more frequently in the 70 mg twice a day regimen than in those treated with a 100 mg once daily regimen.[Ref]
Dermatologic
Very common (10% or more): Skin rash (15 to 21%)
Common (1% to 10%): Flushing, alopecia, dermatitis, eczema, pruritus, acne, dry skin, urticaria, hyperhidrosis, contusion
Uncommon (0.1% to 1%): Acute febrile neutrophilic dermatosis, photosensitivity, pigmentation disorder, panniculitis, skin ulcer, bullous conditions, nail disorder, palmar-plantar erythrodysesthesia syndrome
Rare (Less than 0.1%): Livedo reticularis[Ref]
Renal
Very common (10% or more): Fluid retention (21 to 42%)
Uncommon (0.1% to 1%): Renal failure, urinary frequency, proteinuria[Ref]
Other
Very common (10% or more): Fatigue (19 to 26%), superficial edema (10 to 21%), pyrexia (11 to 18%)
Common (1% to 10%): Tinnitus, pain, generalized edema, asthenia
Uncommon (0.1% to 10%): Vertigo, thrombophlebitis, gynecomastia, irregular menstruation, malaise, temperature intolerance
Postmarketing reports: Deep vein thrombosis[Ref]
Psychiatric
Common (1% to 10%): Depression, insomnia
Uncommon (0.1% to 1%): Anxiety, confusion, affect lability, libido decreased[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Erythema nodosum, unspecified hypersensitivity reaction[Ref]
Ocular
Common (1% to 10%): Visual disturbance, blurred vision, reduction in visual acuity, dry eye
Uncommon (0.1% to 1%): Conjunctivitis
Rare (Less than 0.1%): Visual impairment[Ref]
Oncologic
Uncommon (0.1% to 1%): Tumor lysis syndrome[Ref]
Immunologic
Very common (10% or more): Infection (including bacterial, viral, fungal, non-specified) (10 to 14%)
Common (1% to 10%): Sepsis[Ref]
Frequently asked questions
More about dasatinib
- Check interactions
- Compare alternatives
- Reviews (27)
- Dosage information
- During pregnancy
- Drug class: BCR-ABL tyrosine kinase inhibitors
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
References
1. (2006) "Product Information. Sprycel (dasatinib)." Bristol-Myers Squibb
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.