Cosela Side Effects

Generic name: trilaciclib

Medically reviewed by Drugs.com. Last updated on Mar 18, 2025.

Note: This document provides detailed information about Cosela Side Effects associated with trilaciclib. Some dosage forms listed on this page may not apply specifically to the brand name Cosela.

Applies to trilaciclib: intravenous powder for solution.

Serious side effects of Cosela

Along with its needed effects, trilaciclib (the active ingredient contained in Cosela) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking trilaciclib:

More common side effects

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the site
• bleeding gums
• blue lips, fingernails, or skin
• blurred vision
• bone pain
• chest pain or tightness
• chills
• confusion
• cough
• coughing up blood
• decreased urine
• dizziness
• dry mouth
• fever
• flushed, dry skin
• fruit-like breath odor
• general feeling of discomfort or illness
• headache
• increased menstrual flow or vaginal bleeding
• increased hunger
• increased thirst
• increased urination
• irregular, fast or slow, or shallow breathing
• lack or loss of strength
• loss of appetite
• mood or mental changes
• muscle cramps in the hands, arms, feet, legs, or face
• nausea or vomiting
• numbness and tingling around the mouth, fingertips, or feet
• nosebleeds
• paralysis
• pinpoint red spots on the skin
• prolonged bleeding from cuts
• red or black, tarry stools
• red or dark brown urine
• seizures or tremors
• sneezing
• sore throat
• stomach cramps or pain
• sweating
• swelling of the hands, ankles, feet, or lower legs
• thickening of bronchial secretions
• trouble breathing
• unexplained weight loss
• unusual bleeding or bruising
• unusual tiredness or weakness

For healthcare professionals

Applies to trilaciclib: intravenous powder for injection.

General adverse events

The most common adverse reactions were fatigue, hypocalcemia, hypokalemia, hypophosphatemia, aspartate aminotransferase increased, headache, and pneumonia^[Ref]

Hypersensitivity

• Common (1% to 10%): Infusion related reaction, anaphylaxis^[Ref]

Local

• Common (1% to 10%): Infusion-related reaction, asthenia^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myositis^[Ref]

Hepatic

• Very common (10% or more): Increased aspartate aminotransferase (17%)^[Ref]

Respiratory

• Common (1% to 10%): Pneumonia (10%)
• Uncommon (0.1% to 1%): Respiratory failure^[Ref]

Other

Fatal adverse reactions included pneumonia, respiratory failure, acute respiratory failure, hemoptysis, and cerebrovascular accident^[Ref]

Hematologic

• Very common (10% or more): Neutropenia (32%), anemia (16%), thrombocytopenia (18%)
• Common (1% to 10%): Thrombosis, febrile neutropenia, leukopenia
• Uncommon (0.1% to 1%): Hemoptysis, lymphopenia^[Ref]

Nervous system

• Very common (10% or more): Fatigue (34%), headache (13%)^[Ref]

Cardiovascular

• Common (1% to 10%): Peripheral edema, thrombosis
• Uncommon (0.1% to 1%): Cerebrovascular accident, ischemic stroke^[Ref]

Dermatologic

• Common (1% to 10%): Skin rash, urticaria^[Ref]

Endocrine

• Very common (10% or more): Hypocalcemia (24%), hypokalemia (22%), hypophosphatemia (21%)
• Common (1% to 10%): Hyperglycemia^[Ref]

Gastrointestinal

• Common (1% to 10%): Upper abdominal pain^[Ref]

Further information

Cosela side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer