Cinvanti Side Effects
Generic name: aprepitant
Medically reviewed by Drugs.com. Last updated on Feb 7, 2024.
Note: This document contains side effect information about aprepitant. Some dosage forms listed on this page may not apply to the brand name Cinvanti.
Applies to aprepitant: intravenous emulsion. Other dosage forms:
Serious side effects of Cinvanti
Along with its needed effects, aprepitant (the active ingredient contained in Cinvanti) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking aprepitant:
More common
- Blurred vision
- confusion
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- sweating
- unusual tiredness or weakness
Rare
- Bloody, black, or tarry stools
- burning feeling while urinating
- chest pain or discomfort
- chills
- cough
- defects in intelligence, short-term memory, learning ability, and attention
- difficult or painful urination
- fast, irregular, pounding, or racing heartbeat or pulse
- fever
- frequent urination
- general feeling of discomfort or illness
- heartburn
- increased sensitivity of the skin to sunlight
- increased volume of pale, dilute urine
- indigestion
- lightheadedness, dizziness, or fainting
- lower back or side pain
- pale skin
- redness or other discoloration of the skin
- severe and continuing nausea
- severe stomach pain, cramping, burning
- severe sunburn
- slow heartbeat
- sore throat
- swelling
- tender, swollen glands in the neck
- trouble breathing
- trouble walking
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- vomiting
- vomiting of material that looks like coffee grounds
Incidence not known
- Blistering, peeling, or loosening of the skin
- chest tightness
- diarrhea
- difficulty swallowing
- hives, itching, skin rash
- joint or muscle pain
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- unusual tiredness or weakness
Other side effects of Cinvanti
Some side effects of aprepitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Rare
- Abnormal dreams
- acne
- anxiety
- body aches or pain
- burning, dry, or itching eyes
- change or loss in taste
- confusion about identity, place, and time
- congestion
- continuing ringing or buzzing or other unexplained noise in the ears
- discharge, excessive tearing
- dry throat
- false or unusual sense of well-being
- feeling of warmth
- hearing loss
- hoarseness
- increased sweating
- increased thirst
- muscle cramp or weakness
- oily skin
- redness of the face, neck, arms and occasionally, upper chest
- redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
- runny nose
- sleepiness or unusual drowsiness
- sneezing
- stomach discomfort
- voice changes
- weight gain
For Healthcare Professionals
Applies to aprepitant: intravenous emulsion, oral capsule, oral powder for reconstitution.
General
The most commonly reported side effects included headache, fatigue, neutropenia, constipation, and pruritus.[Ref]
Other
Very common (10% or more): Fatigue (up to 15%)
Common (1% to 10%): Asthenia, extremity pain, pyrexia
Uncommon (0.1% to 1%): Malaise
Rare (0.01% to 0.1%): Tinnitus
Frequency not reported: Hypothermia, pain[Ref]
Hematologic
Very common (10% or more): Neutropenia (up to 13%)
Common (1% to 10%): Anemia, hemoglobin decreased, leukopenia, white blood cell count decreased
Uncommon (0.1% to 1%): Febrile neutropenia, thrombocytopenia
Rare (0.01% to 0.1%): Neutrophil count decreased
Frequency not reported: Blood albumin decreased[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (up to 13%)
Common (1% to 10%): Abdominal pain, constipation, dyspepsia, eructation, flatulence, nausea, vomiting
Uncommon (0.1% to 1%): Dry mouth, gastritis, gastroesophageal reflux disease, oral candidiasis
Rare (0.01% to 0.1%): Abdominal distention, duodenal ulcer perforation, feces hard, neutropenic colitis, stomatitis
Frequency not reported: Abdominal pain upper, acid reflux, bowel sounds abnormal, epigastric discomfort, obstipation, stomach discomfort, subileus[Ref]
Local
Common (1% to 10%): Infusion-site erythema, infusion-site induration, infusion-site pain, infusion-site pruritus, infusion-site thrombophlebitis
Uncommon (0.1% to 1%): injection-site pain, vessel puncture-site pain[Ref]
Cardiovascular
Common (1% to 10%): Bradycardia, flushing, hypertension, hypotension
Uncommon (0.1% to 1%): Edema peripheral, flushing, hot flush, palpitations
Rare (0.01% to 0.1%): Cardiovascular disorder, chest discomfort, edema
Frequency not reported: Blood pressure decreased, hematoma, operative hemorrhage[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache, peripheral neuropathy
Uncommon (0.1% to 1%): Dysgeusia, somnolence
Rare (0.01% to 0.1%): Cognitive disorder, gait disturbance, lethargy
Frequency not reported: Hypoesthesia, sensory disturbance, syncope
Postmarketing reports: Ifosfamide-induced neurotoxicity[Ref]
Hepatic
Common (1% to 10%): ALT increased, AST increased
Uncommon (0.1% to 1%): Blood alkaline phosphatase increased
Frequency not reported: Blood bilirubin increased/bilirubin increased[Ref]
Respiratory
Common (1% to 10%): Cough, hiccups
Uncommon (0.1% to 1%): Dyspnea, oropharyngeal pain, pharyngitis
Rare (0.01% to 0.1%): Postnasal drip, sneezing, throat irritation
Frequency not reported: Hypoxia, respiratory depression, wheezing[Ref]
Metabolic
Common (1% to 10%): Decreased appetite, dehydration
Uncommon (0.1% to 1%): Blood potassium decreased/hypokalemia
Rare (0.01% to 0.1%): Blood sodium decreased/hyponatremia, polydipsia, weight decreased
Frequency not reported: Blood glucose increased/hyperglycemia, hypovolemia, thirst, weight gain[Ref]
Dermatologic
Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Acne, alopecia, hyperhidrosis, rash
Rare (0.01% to 0.1%): Photosensitivity reaction, rash pruritic, seborrhea, skin lesion, Stevens-Johnson syndrome, toxic epidermal necrolysis
Frequency not reported: Oily skin, urticaria[Ref]
Psychiatric
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Anxiety
Rare (0.01% to 0.1%): Abnormal behavior, agitation, behavior changes, disorientation, euphoria/euphoric mood
Frequency not reported: Dream abnormality[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Dysuria, proteinuria
Rare (0.01% to 0.1%): Pollakiuria, red blood cells urine positive, urine output increased
Frequency not reported: Microscopic hematuria, polyuria[Ref]
Musculoskeletal
Uncommon (0.1% to 1%): Musculoskeletal pain
Rare (0.01% to 0.1%): Muscular weakness, muscle spasms
Frequency not reported: Dysarthria, muscle cramp, myalgia[Ref]
Renal
Uncommon (0.1% to 1%): Blood urea increased
Rare (0.01% to 0.1%): Glucose urine present[Ref]
Immunologic
Rare (0.01% to 0.1%): Candidiasis, staphylococcal infection
Frequency not reported: Postoperative infection, wound dehiscence[Ref]
Ocular
Rare (0.01% to 0.1%): Conjunctivitis
Frequency not reported: Miosis, visual acuity reduced[Ref]
Hypersensitivity
Frequency not reported: Anaphylactic reactions, angioedema, hypersensitivity reactions
Postmarketing reports: Anaphylactic shock, anaphylaxis[Ref]
Frequently asked questions
More about Cinvanti (aprepitant)
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- Drug class: NK1 receptor antagonists
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References
1. (2003) "Product Information. Emend (aprepitant)." Merck & Co., Inc
2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
3. Cerner Multum, Inc. "Australian Product Information."
4. (2019) "Product Information. Cinvanti (aprepitant)." Heron Therapeutics
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.