Chlorostat 4 Side Effects
Generic name: chlorhexidine topical
Medically reviewed by Drugs.com. Last updated on Apr 26, 2024.
Note: This document contains side effect information about chlorhexidine topical. Some dosage forms listed on this page may not apply to the brand name Chlorostat 4.
Applies to chlorhexidine topical: topical application liquid, topical application solution. Other dosage forms:
Serious side effects of Chlorostat 4
Along with its needed effects, chlorhexidine topical (the active ingredient contained in Chlorostat 4) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking chlorhexidine topical:
Incidence not known
- Blistering, burning, itching, peeling, skin rash, redness, swelling, or other signs of irritation on the skin
- swelling of the face, hands, or feet
- trouble breathing
For Healthcare Professionals
Applies to chlorhexidine topical: compounding liquid, mucous membrane insert, mucous membrane liquid, topical dressing, topical liquid, topical pad, topical soap, topical solution, topical sponge.
General
The most commonly reported side effects include toothache, tongue coating, skin irritation and hypersensitivity reactions.[Ref]
Gastrointestinal
Toothache occurred most often in patients receiving the periodontal chip, and included dental/gingival/mouth pain, tenderness, aching, throbbing, soreness, discomfort, or sensitivity.
Tooth disorder occurred most often in patients receiving the periodontal chip, and included broken/cracked/fractured teeth, mobile teeth, and lost bridges/crowns/fillings.[Ref]
Very common (10% or more): Toothache (up to 50.7%)
Common (1% to 10%): Dry mouth, glossodynia, oral paresthesia, dyspepsia, ulcerative stomatitis, gum hyperplasia
Frequency not reported: Mouth irritation, coated tongue, desquamation/superficial desquamation/oral mucosa swelling, parotid gland swelling, burning sensation of the tongue, increased dental calculus formation, aphthous ulcer, gingivitis/grossly obvious gingivitis, geographic tongue, tooth disorder, dental/gingival/mouth pain, broken/cracked/fractured teeth, mobile teeth, lost bridges/crowns/fillings, discoloration of the teeth, gums, and dorsum of the tongue
Postmarketing reports: Stomatitis, glossitis, ulcer, glossal edema, sialadenitis/inflammation of the salivary glands[Ref]
Respiratory
Bronchospasm occurred with hypersensitivity reactions.
Upper respiratory tract infection and sinusitis have occurred most commonly in patients receiving the periodontal chip.[Ref]
Very common (10% or more): Upper respiratory tract infection (up to 28.4%), sinusitis (up to 13.8%)
Common (1% to 10%): Bronchitis, pharyngitis
Frequency not reported: Bronchospasm, rhinitis, coughing, dyspnea[Ref]
Nervous system
Common (1% to 10%): Ageusia/dysgeusia, hypoesthesia
Frequency not reported: Transient dysgeusia, headache, loss of consciousness
Postmarketing reports: Hypesthesia, paresthesia[Ref]
Musculoskeletal
Common (1% to 10%): Arthrosis, tendinitis
Frequency not reported: Back pain, myalgia, arthralgia[Ref]
Local
Frequency not reported: Ulceration, desquamation, keratinization, mucocele, short frenum, pain, tenderness, aching, throbbing, soreness, discomfort, sensitivity
Postmarketing reports: Minor irritation[Ref]
Dermatologic
Frequency not reported: Rash, erythema/generalized erythema, urticaria, dermatitis, pruritus, eczema, skin irritation, blisters, cold sweat, irritative or allergic skin reactions[Ref]
Rash, erythema, and urticaria occurred with hypersensitivity reactions.
Dermatitis, pruritus, erythema, eczema, rash, urticaria, skin irritation, and blisters occurred with allergic skin reactions.[Ref]
Other
Frequency not reported: Chemical burns in neonates, trauma, abscess, influenza-like symptoms, deafness, sensitive tissue irritation[Ref]
Cardiovascular
Cardiac arrest, circulatory collapse, hypotension, and tachycardia occurred as hypersensitivity reactions.[Ref]
Frequency not reported: Cardiac arrest, circulatory collapse, hypotension, tachycardia, hypertension[Ref]
Hypersensitivity
Frequency not reported: Anaphylactic shock, anaphylactoid reactions/fatal anaphylactic reactions
Postmarketing reports: Hypersensitivity and anaphylaxis[Ref]
Ocular
Exposure of the eye to chlorhexidine cleanser, generally during preparation for facial surgery, has resulted in eye pain, edema of the epithelium, keratitis, inflammation of the conjunctiva, corneal epithelial cell loss, chronic corneal ulcers, and opacification. Corneal transplantation to correct permanent damage has been required in some patients.
Allergic conjunctivitis is rarely associated with the use of contact lens solutions which contain low concentrations of chlorhexidine as a preservative.[Ref]
Frequency not reported: Irreversible corneal damage, irritation to the conjunctiva[Ref]
Genitourinary
Frequency not reported: Dysmenorrhea, hematuria[Ref]
Hematuria occurred after bladder irrigation.[Ref]
Immunologic
Frequency not reported: Allergy[Ref]
More about Chlorostat 4 (chlorhexidine topical)
- Check interactions
- Compare alternatives
- Latest FDA alerts (3)
- Dosage information
- During pregnancy
- Drug class: antiseptic and germicides
- Breastfeeding
Patient resources
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Professional resources
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Other formulations
References
1. (2022) "Product Information. Peridex (chlorhexidine topical)." Procter and Gamble Pharmaceuticals
2. (2022) "Product Information. PerioChip (chlorhexidine topical)." Apothecon Inc
3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
4. Cerner Multum, Inc. "Australian Product Information."
5. (2009) "Product Information. Biopatch (chlorhexidine topical)." Johnson and Johnson Medical Inc
6. (2011) "Product Information. Chlorhexidine Gluconate (chlorhexidine topical)." A-S Medication Solutions
7. (2011) "Product Information. Hibiclens (chlorhexidine topical)." Astra-Zeneca Pharmaceuticals
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.