Ceftazidime Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 17, 2024.

Applies to ceftazidime: injection powder for solution.

Common side effects of ceftazidime

Some side effects of ceftazidime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• red streaks on the skin
• swelling, tenderness, or pain at the injection site

Serious side effects of ceftazidime

Along with its needed effects, ceftazidime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftazidime:

Less common side effects

• abdominal or stomach cramps or tenderness
• bloating
• bluish color
• changes in skin color
• diarrhea, watery and severe, which may also be bloody
• fever
• increased thirst
• itching of the vagina or genital area
• nausea or vomiting
• pain
• pain during sexual intercourse
• swelling at the site of injection
• swelling of the foot or leg
• tenderness
• thick, white vaginal discharge with no odor or with a mild odor
• unusual tiredness or weakness
• unusual weight loss
• white patches in the mouth or throat or on the tongue
• white patches with diaper rash

Rare side effects

• back, leg, or stomach pains
• bleeding gums
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chills
• cough
• dark urine
• difficulty with breathing
• difficulty with swallowing
• dizziness
• fast heartbeat
• general body swelling
• headache
• hives
• itching
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of appetite
• nosebleeds
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• shortness of breath
• skin rash
• sore throat
• tightness in the chest
• wheezing
• yellowing of the eyes or skin

Incidence not known

• agitation
• bloody or cloudy urine
• blurred vision
• change in consciousness
• chest pain
• clay-colored stools
• confusion
• coughing up blood
• decreased frequency or amount of urine
• diarrhea
• difficult or painful urination
• drowsiness
• hallucinations
• increased blood pressure
• increased menstrual flow or vaginal bleeding
• increased thirst
• irritability
• loss of consciousness
• lower back or side pain
• muscle twitching or jerking
• nosebleeds
• paralysis
• prolonged bleeding from cuts
• red or black, tarry stools
• red or dark brown urine
• rhythmic movement of the muscles
• seizures
• sores, ulcers, or white spots on the lips or in the mouth
• stiff neck
• sudden decrease in the amount of urine
• swelling of the face, fingers, or lower legs
• swollen or painful glands
• troubled breathing
• unpleasant breath odor
• unusual bleeding or bruising
• vomiting of blood
• watery or bloody diarrhea
• weight gain

For healthcare professionals

Applies to ceftazidime: injectable powder for injection, intravenous powder for injection, intravenous solution.

Hepatic adverse events

• Common (1% to 10%): Transient elevations in 1 or more liver enzymes (alkaline dehydrogenase, ALT, AST, GGT)
• Very rare (less than 0.01%): Jaundice
• Postmarketing reports: Cholestasis, hyperbilirubinemia, liver dysfunction^[Ref]

Local

• Common (1% to 10%): Inflammation, pain, phlebitis, thrombophlebitis
• Frequency not reported: Superficial desquamation around injection site^[Ref]

Inflammation and pain occurred after IM administration.

Phlebitis and thrombophlebitis occurred with IV administration.^[Ref]

Hematologic

• Common (1% to 10%): Eosinophilia, positive Coombs test, thrombocytosis
• Uncommon (0.1% to 1%): Leukopenia, neutropenia, thrombocytopenia
• Frequency not reported: Agranulocytosis, hemolytic anemia, lymphocytosis, positive Coombs test without hemolysis
• Postmarketing reports: Aplastic anemia, pancytopenia, prothrombin time prolonged^[Ref]

Approximately 5% of patients developed a positive Coombs test.^[Ref]

Dermatologic

• Common (1% to 10%): Maculopapular rash, rash, urticarial rash
• Uncommon (0.1% to 1%): Pruritus
• Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis
• Frequency not reported: Drug reaction with eosinophilia and systemic symptoms (DRESS)
• Postmarketing reports: Urticaria^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea
• Uncommon (0.1% to 1%): Abdominal pain, antibacterial agent-associated colitis/diarrhea, colitis, nausea, vomiting
• Frequency not reported: Pseudomembranous colitis^[Ref]

Pseudomembranous colitis may have been presented as diarrhea or colitis.^[Ref]

Metabolic

• Common (1% to 10%): Transient elevations in LDH
• Postmarketing reports: False-positive test for urinary glucose^[Ref]

Renal

• Uncommon (0.1% to 1%): Transient elevations of blood urea/blood urea nitrogen (BUN)/serum creatinine
• Very rare (less than 0.01%): Acute renal failure, interstitial nephritis
• Postmarketing reports: Renal dysfunction, toxic nephropathy^[Ref]

Nervous system

• Uncommon (0.1% to 1%): Dizziness, headache
• Very rare (less than 0.01%): Bad taste, paresthesia,
• Frequency not reported: Asterixis, coma, convulsions, encephalopathy, myoclonia, neurological sequelae, neuromuscular excitability, seizures, tremor^[Ref]

Neurological sequelae occurred in patients with renal dysfunction who did not receive appropriate dose adjustments and included coma, convulsions, encephalopathy, myoclonia, and tremor.^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Candidiasis, oral thrush^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Vaginitis^[Ref]

Other

• Uncommon (0.1% to 1%): Fever^[Ref]

Hypersensitivity

• Very rare (less than 0.01%): Anaphylaxis, angioedema
• Postmarketing reports: Allergic reactions^[Ref]

Anaphylaxis included bronchospasm, cardiopulmonary arrest, and/or hypotension.^[Ref]

Cardiovascular

• Very rare (less than 0.01%): Hypotension
• Frequency not reported: Hot flushes
• Postmarketing reports: Cardiopulmonary arrest, hemorrhage^[Ref]

Respiratory

• Very rare (less than 0.01%): Bronchospasm^[Ref]

Further information

Ceftazidime side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer